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Four SNPs in IFNGR2 (show IFNGR2 ELISA Kits), IL12RB1 (show IL12RB1 ELISA Kits), IL12RB2 (show IL12RB2 ELISA Kits), and IL23R were found to be associated with the MAP infection status of the resource population.
an evaluation of what is currently known about the protective role of R381Q variant in IL-23R gene in immune-based diseases (Review).
Th17 cells expressed consistent high levels of the IL-12Rbeta1 subunit, which appeared a better predictor of responsiveness to IL-23 (show IL23A ELISA Kits) than the expression of the IL-23R subunit.
We conclude that variants in IL-23A (show IL23A ELISA Kits) and IL-23R genes were associated with the risk of multiple sclerosis or other inflammatory demyelinating diseases.
IL-23 (show IL23A ELISA Kits) R (rs7517847) and LEP (show LEP ELISA Kits) (rs7799039) polymorphisms were associated with an increased risk but not affecting the clinical presentation of HCC (show FAM126A ELISA Kits) among Egyptian patients
In a Turkish population, IL23R polymorphism is a risk factor for UC and is protective against CD.
The current study emphasizes the lack of association of IL23R and IL17 (show IL17A ELISA Kits) polymorphisms with rheumatoid arthritis susceptibility in the Algerian population. However, the data showed the relationship between IL23R and IL17A (show IL17A ELISA Kits) polymorphisms and the production of the different RF isotypes in rheumatoid arthritis patients
Haplotype of non-synonymous IL-23R variants increase susceptibility to severe malarial anemia in children of a holoendemic P. falciparum transmission area.
there is a positive association between the GWAS reported rs3762318 and leprosy, and SLC35D1 and IL23R might be the causal genes
this study identified susceptibility single nucleotide polymorphisms in IL23R with Behcet's disease in Han Chinese
HLA-B51 is a primary association marker in predisposition to Behcet disease, with IL-23R and IL12A being the additional strongest loci.
RBPJ (show RBPJ ELISA Kits) binds and trans-activates the Il23r promoter and induces IL-23R expression and represses anti-inflammatory IL-10 (show IL10 ELISA Kits) production in Th17 cells.
Epithelial IL-23R signaling enables protective IL-22 (show IL22 ELISA Kits) responses in experimental colitis.
Study highlights the importance of IL-23R expression level and the instability of Foxp3 (show FOXP3 ELISA Kits)+ regulatory T cells in the development of inflammatory bowel diseases.
Differential splicing generates antagonistic soluble IL-23R (sIL (show STIL ELISA Kits)-23R) variants, which might limit IL-23 (show IL23A ELISA Kits)-mediated immune responses. Here, ectodomain shedding of IL-23R was identified as an alternative pathway for the generation of sIL (show STIL ELISA Kits)-23R.
Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 (show IL23A ELISA Kits) receptor signaling and IL-17A (show IL17A ELISA Kits) production in patients with severe asthma.
Data show the contribution of IL-23/IL-23 (show IL23A ELISA Kits) receptor and IL-7/IL-7 (show IL7 ELISA Kits) receptor signaling in Th17 and Th1 (show HAND1 ELISA Kits) cell dynamics during experimental autoimmune encephalomyelitis (EAE).
Study provides evidence that IL-23 (show IL23A ELISA Kits)/IL-23R plays a critical role in brain ischemic injury
IL-23 (show IL23A ELISA Kits) plus T-cell receptor signalling results in significant upregulation of IL-23 receptor expressed predominantly on CD4 (show CD4 ELISA Kits)(hi)CD8 (show CD8A ELISA Kits)(hi)CD3 (show CD3E ELISA Kits)(+)alphabetaTCR(+) thymocytes, and leads to RORgammat-dependent apoptosis.
Homeostatic IL-23 receptor signaling limits Th17 response through IL-22 (show IL22 ELISA Kits)-mediated containment of commensal microbiota.
Characterization of potent IL-23R small-peptide modulator, 2305 (teeeqqly), that decreases inflammatory response.
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.
, interleukin 23 receptor
, interleukin-23 receptor-like
, IL-23 receptor
, interleukin 23 receptor-like