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Human MUC4 ELISA Kit for Sandwich ELISA - ABIN414525
Maker, Katabi, Gonen, DeMatteo, DAngelica, Fong, Jarnagin, Brennan, Allen: Pancreatic cyst fluid and serum mucin levels predict dysplasia in intraductal papillary mucinous neoplasms of the pancreas. in Annals of surgical oncology 2011
the role of Muc4 in driving intestinal inflammation and inflammation-associated tumorigenesis
Results show that while MUC4 is highly expressed in the mouse uterus, it is not a major mucin (show SLC13A2 ELISA Kits) in normal human endometrium. Rather, MUC4 is a potential marker of endometrial adenocarcinoma in a subset of patients.
Using the Pdx1 (show PDX1 ELISA Kits)-Cre; LStopL-K-rasG12D mouse model of pancreatic carcinogenesis, in vivo early Muc4 neo-expression of in pancreatic intraepithelial neoplastic lesions induced by mutated hK-ras is correlated with the ERK (show EPHB2 ELISA Kits), JNK (show MAPK8 ELISA Kits) and NF-kappaB (show NFKB1 ELISA Kits) signaling pathways.
Data show that Muc4 is upregulated and interacts with erbB2 (show ERBB2 ELISA Kits) in gallbladders from BK5.erbB2 (show ERBB2 ELISA Kits) mice suggesting its important role during gallbladder carcinogenesis and/or cancer growth by potentiating erbB2 (show ERBB2 ELISA Kits) signaling.
This study delineates the association and the downstream mechanisms of MUC4-regulated elevation of lipocalin-2 (show LCN2 ELISA Kits) and its clinical significance for prognosis of pancreatic cancer.
MUC4-NIDO domain significantly contributes to the MUC4-mediated metastasis of PC cells
ErbB2 (show ERBB2 ELISA Kits) and MUC4, which interact physically, activate different intracellular signalling pathways to regulate biological properties of CAPAN-2 pancreatic cancer cells
As a luminal surface component, the MUC4 is situated to contribute to the non-adhesive luminal surface and to act as an intrinsic protection and survival factor for blood vessels
MUC4 is regulated at the transcriptional level by CDX-1 (show CDX1 ELISA Kits) and -2, HNF-1 alpha (show HNF1A ELISA Kits) and -1 beta, FOXA1 (show FOXA1 ELISA Kits)/A2, HNF-4 alpha (show HNF4A ELISA Kits) and -4 gamma, and GATA-4 (show GATA4 ELISA Kits), -5, and -6 factors in a cell-specific manner
the expression of mucins 1 to 4 and trefoil factor 3 (show TFF3 ELISA Kits) was down-regulated in the ileum and colon of conventional and reconventionalized mice compared with germ-free animals
Study provides evidence that AMOP domain plays the key role in MUC4-mediated tumor angiogenesis and metastasis of pancreatic cancer cells partly through the NOTCH3 (show NOTCH3 ELISA Kits) signaling and its downstream target genes: VEGF-A (show VEGFA ELISA Kits), MMP-9 (show MMP9 ELISA Kits) and ANG-2 (show ANGPT2 ELISA Kits).
elevated levels of bile acid increase the tumorigenic potential of pancreatic cancer cells by inducing FXR (show NR1H4 ELISA Kits)/FAK (show PTK2 ELISA Kits)/c-Jun (show JUN ELISA Kits) axis to upregulate MUC4 expression.
High MUC4 expression is associated with CRLF2 (show CRLF2 ELISA Kits)-rearranged acute lymphoblastic leukemia.
Low expression of MUC4 was associated with favorable survival, whereas high MUC4 expression did not correlate with survival in resectable pancreatic cancer patients receiving adjuvant gemcitabine treatment.
the present study provides evidence that hypoxia negatively regulates MUC4 expression in PC by affecting its stability.
Studies indicate that a positive or high expression level of mucin 4 (MUC4) was significantly related to poor survival in patients with resected cholangiocarcinoma (CC).
MUC4beta participates in the corticosteroid resistance process, inhibiting normal GRalpha nuclear function. The high expression of MUC4 in patients with CRSwNP might participate in corticosteroid resistance.
Data indicate that microRNA miR (show MLXIP ELISA Kits)-211 can directly target the 3'UTR (show UTS2R ELISA Kits) of mucin-4 (MUC4) and inhibit its expression at both mRNA and protein levels.
The main significance of this work is the discovery of EPO (show EPO ELISA Kits) as a novel ligand for the HER2 (show ERBB2 ELISA Kits) receptor. Following HER2 (show ERBB2 ELISA Kits) activation, EPO (show EPO ELISA Kits) induces activation of FAK (show PTK2 ELISA Kits) and subsequent activation of beta1-integrin, via inside-out signaling. This complex results in downstream activation of ERK1/2 (show MAPK1/3 ELISA Kits) and a sustained up regulation of both MUC4 and the HER2 (show ERBB2 ELISA Kits) receptor
MUC4 promotes the migration and proliferation of BxPC-3 cells.
Polymorphism of FUT1 (show FUT1 ELISA Kits) and MUC4 associated with resistance to colibacteriosis was determined.
Haplotype phylogeny analyses indicated that MUC4 had evolved divergently in Chinese and Western pigs.
A SNP in exon 7 of the mucin 4 (MUC4) gene (DQ848681:g.8227C>G), shown to be in close linkage disequilibrium with the F4bcR locus, has been used as marker to identify ETEC susceptible pigs.
data suggest that MUC4 could play an important role in the establishment of an optimal uterine environment that would increase embryonic survival during pig gestation
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats.
, mucin 4, ASGP
, pancreatic adenocarcinoma mucin
, testis mucin
, mucin 4, tracheobronchial
, tracheobronchial mucin
, pre-sialomucin complex
, sialomucin ascites sialoglycoprotein-1
, sialomucin complex