Browse our P2RX7 Proteins (P2RX7)

Full name:
Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 Proteins (P2RX7)
On www.antibodies-online.com are 8 Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) Proteins from 3 different suppliers available. Additionally we are shipping P2RX7 Antibodies (118) and P2RX7 Kits (15) and many more products for this protein. A total of 150 P2RX7 products are currently listed.
Synonyms:
AI467586, P2RX7, P2X(7), p2x7, P2X7R, p2xr7
list all proteins Gene Name GeneID UniProt
P2RX7 5027 Q99572
P2RX7 18439 Q9Z1M0
Rat P2RX7 P2RX7 29665 Q64663

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P2RX7 Proteins (P2RX7) by Origin

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More Proteins for P2RX7 Interaction Partners

Zebrafish Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) interaction partners

  1. Blockade of the P2X7 receptor reduces cyst formation via ERK (show MAPK1 Proteins)-dependent pathways in a zebrafish model of polycystic kidney disease.

Human Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) interaction partners

  1. P2X7R expression was correlated with enhanced tumor grade and metastasis in colorectal carcinoma patients.

  2. Our present study shows that loss of function of the P2X7 receptor in mice induces retinal changes representing characteristics of early age-related macular degeneration.

  3. Single nucleotide polymorphism in P2X7R gene is associated with pulmonary non-tuberculous mycobacterial disease.

  4. Our results reveal that P2RX7 rs2230911 may be associated with primary gout risk in a Chinese Han male population and allele G may be a susceptibility factor for primary gout.

  5. Together, this body of research suggests that P2X7R may constitute an important therapeutic target for a variety of neurological disorders.

  6. In addition, purinergic receptor P2X, ligand-gated ion channel (show GLRa3 Proteins) 7 (P2X7) was downregulated in CD36 (show CD36 Proteins)-knockdown 3T3-L1 cells, suggesting that the suppression of CD36 (show CD36 Proteins) attenuates adipogenesis via the P2X7 pathway in 3T3-L1 cells.

  7. analysis of the M1/M2 functional imprinting of primary microglia and the role played by P2X7 and miR (show MLXIP Proteins)-125b in amyotrophic lateral sclerosis microglia activation [review]

  8. Study observed a downregulation of purinergic P2X7 receptors in peripheral blood mononuclear cells of amyotrophic lateral sclerosis (ALS) patients compared to controls.

  9. Data suggest that specific serine residues in purinergic receptors play key roles in both agonist binding and receptor sensitization/desensitization: in rat P2rx7, point mutation F288S (phenylalanine 288 > serine) results in a slower rate of ATP binding/unbinding and stabilization of non-sensitized receptor states; in human P2RX7, Y288F (but not Y288S) results in a "rat-like" receptor with a fast deactivation rate.

  10. This study showed that the ATP-gated P2X7 receptor is upregulated in experimental epilepsy and resected hippocampus from epilepsy patients.

Cow (Bovine) Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) interaction partners

  1. For the inflammasome-dependent IL-1beta (show IL1B Proteins) release, bovine monocytes require ATP in addition to a primary stimulus. This IL-1beta (show IL1B Proteins) release depends on potassium efflux, but, in contrast to human and murine monocytes, does not require calcium influx or generation of reaction oxygen and is independent of the P2X7 receptor.

Mouse (Murine) Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 (P2RX7) interaction partners

  1. P2X7 deficiency resolved atherosclerotic plaque inflammation by inhibition of inflammasome activation.

  2. P2RX7 purinoceptor gene knockout alters some of the morphological and mechanical properties of dystrophic bones in a mouse model.

  3. restoration of cholesterol concentrations in cells lacking lipin-2 (show LPIN2 Proteins) decreases ion currents through the P2X7 receptor, and downstream events that drive IL-1beta (show IL1B Proteins) production.

  4. Western blotting indicated altered P2X7R, P2Y2R (show P2RY2 Proteins) and P2Y4R (show P2RY4 Proteins) expression in high glucose exposed bone cells, and in diabetic bone tissue. Moreover, high glucose blunted normal P2R- and flow-induced Ca2 (show CA2 Proteins)+ signaling and ATP release from osteocytes

  5. Together, these results demonstrate that activation of the P2X7 receptor is involved in the exacerbated immune response observed during influenza virus infection.

  6. this study shows that blockage of P2X7R by brilliant blue G exerts a protective effect on graft versus host reaction post hematopoietic stem cell transplantation and improves liver function suggesting that this receptor could be considered as an attractive target for treatment of GVHD

  7. In response to SD, the KO mice failed to increase hypothalamic adenosine deaminase (show ADA Proteins) and P2X4R (show P2RX4 Proteins) mRNAs. Further, hypothalamic lncRNA expressions varied by strain, and with SD. Current data are consistent with a role for the P2X7R in thermoregulation and lncRNA involvement in purinergic signaling.

  8. In the brain samples, expressions of P2Y4 (show P2RY4 Proteins) and P2X7 were significantly reduced, whereas that of P2Y1 (show P2RY1 Proteins) was significantly elevated in an age-dependent manner.

  9. results suggest a neuronal activity-dependent P2X7R expression which is induced by the transcription factor Sp1 (show SP1 Proteins) and repressed in a calcium-dependent manner by microRNA-22

  10. The data are consistent with the hypothesis that P2X7R contributes to alveolar epithelial barrier function through effects on GSK-3beta.

P2RX7 Protein Profile

Protein Summary

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.

Alternative names and synonyms associated with P2RX7

  • purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7)
  • purinergic receptor P2X, ligand-gated ion channel, 7 (p2rx7)
  • purinergic receptor P2X, ligand-gated ion channel, 7 (P2rx7)
  • AI467586 protein
  • P2RX7 protein
  • P2X(7) protein
  • p2x7 protein
  • P2X7R protein
  • p2xr7 protein

Protein level used designations for P2RX7

P2X purinoceptor 7 , purinergic receptor P2X, ligand-gated ion channel, 7 , p2X purinoceptor 7-like , ATP receptor , P2X7 receptor , P2Z receptor , purinergic receptor P2X7 variant A , P2X7 purinoceptor , purinergic receptor P2X7

GENE ID SPECIES
100058464 Equus caballus
387298 Danio rerio
452318 Pan troglodytes
699455 Macaca mulatta
771952 Gallus gallus
100458463 Pongo abelii
100588362 Nomascus leucogenys
5027 Homo sapiens
448778 Canis lupus familiaris
286814 Bos taurus
18439 Mus musculus
29665 Rattus norvegicus
497623 Sus scrofa
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