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PTIP promotes double-strand break repair through a direct role in homologous recombination.
PPM1B (show PPM1B ELISA Kits) can dephosphorylate the Pax2 (show PAX2 ELISA Kits) activation domain and displace the adaptor protein PTIP, thus inhibiting H3K4 methylation and gene activation.
uncovered a nuclease (show DCLRE1C ELISA Kits), Artemis (show DCLRE1C ELISA Kits), as a PTIP-binding protein
PITX2 (show PITX2 ELISA Kits) and PTIP co-occupy the promoter of the PITX2 (show PITX2 ELISA Kits)'s transcriptional target.
Polyglutamine expansion AR sequesters PTIP to attenuate DNA repair and increase genomic instability.
a new clue to identify the role of PTIP in DNA damage pathway
PTIP controls expression of P (show PPARG ELISA Kits)PARgamma and C/ (show CEBPA ELISA Kits)EBPalpha, the two principal adipogenic transcription factors, and is therefore required for adipogenesis.
PTIP (PAXIP1) is a strong inhibitor of the trans-activation activities of Pax2A and Pax2B on the glucagon (show GCG ELISA Kits) gene promoter and p8 binding to PTIP prevents inhibition of this promoter.
identified tandem BRCT (BRCA1 carboxyl-terminal) domains in PTIP and in BRCA1 as phosphoserine- or phosphothreonine-specific binding modules that recognize substrates phosphorylated by the kinases ATM and ATR in response to gamma-irradiation
hPTIP (PAXIP1) shows increased association with 53BP1 (show TP53BP1 ELISA Kits) in response to ionizing radiation but not in response to other DNA-damaging agents.
Immunodepletion of PTIP/Swift from Xenopus extracts prevented efficient proliferating cell nuclear antigen (show PCNA ELISA Kits) ubiquitination and polymerase eta (show POLH ELISA Kits) recruitment to chromatin during replicative stress
a PTIP-PA1 subcomplex functions independently from the MLL3/MLL4 complex to mediate transcription during CSR
Study concludes that 53BP1 (show TP53BP1 ELISA Kits) promotes productive class switch recombination and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 (show RIF1 ELISA Kits) and PTIP.
PAXIP1 controls distinct transcriptional programs during DP differentiation necessary for Tcra locus accessibility, licensing mature thymocytes for trafficking and natural killer T cell development.
PTIP plays an important role in the DNA repair process associated with the development of mature spermatozoa.
PTIP stabilizes the Pax5 (show PAX5 ELISA Kits) DNA interactions that promote chromatin looping and regulate transcriptional responses needed for class switch recombination.
Data show that loss of PTIP resulting in subtle changes in gene expression patterns and lower H3K4 methylation.
PTIP accumulation at double stranded breaks contributes to class switch recombination and genome stability independently of Igh switch transcription
PTIP is an essential element of the cell proliferation machinery, perhaps by functioning in the DNA repair pathways
Pax (show PXN ELISA Kits) transactivation domain-interacting protein is required for the urine concentration mechanism by modulating arginine vasopressin receptor 2 (show AVPR2 ELISA Kits) and AQP2 (show AQP2 ELISA Kits) expression in the inner medulla.
This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis.
PAX transcription activation domain interacting protein 1 like
, PAX-interacting protein 1
, protein encoded by CAG trinucleotide repeats
, PAX transactivation activation domain-interacting protein
, SMAD wing for transcriptional activation
, protein Swift
, PAX interacting protein 1