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Human Poliovirus Receptor Protein expressed in Human Cells - ABIN2002083
Mendelsohn, Wimmer, Racaniello: Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily. in Cell 1989
Show all 7 Pubmed References
Studies showed that CD155 was frequently overexpressed in human malignant tumors. Its overexpression promotes tumor cell invasion and migration, and is associated with tumor progression. [review]
soluble CD226 (show CD226 Proteins) elevated in sera of CTCL (show TSPYL2 Proteins) patients would be important for tumor immunity by interacting with CD155 on tumor cells.
data reveal that MICA (show MICA Proteins) and PVR are directly regulated by human cytomegalovirus immediate early (show JUN Proteins) proteins, and this may be crucial for the onset of an early host antiviral response
The SNP detection assay was successfully developed for identification of Ala67Thr polymorphism in human PVR/CD155 gene. The SNP assay will be useful for large scale screening of DNA samples.
implying that TIGIT (show TIGIT Proteins) exerts immunosuppressive effects by competing with DNAM-1 (show CD226 Proteins) for the same ligand, CD155
The present study provides evidence that regulation of the PVR/CD155 DNAM-1 (show CD226 Proteins) ligand expression by nitric oxide may represent an additional immune-mediated mechanism and supports the anti-myeloma activity of nitric oxide donors.
Our findings suggest that loss of CD155 expression may play an important role in the immune escape of HCC (show FAM126A Proteins) cells and thus CD155 may serve as a prognostic marker as well as a potential therapeutic target for HCC (show FAM126A Proteins).
CD155 may play a critical role through both immunological and non-immuno logical mechanisms in pancreatic cancer and may be a therapeutic target for this intractable malignancy.
CD155 (PVR/Necl5) mediates a costimulatory signal in CD4 (show CD4 Proteins)+ T cells and regulates allergic inflammation.
The cell-surface receptor (Pvr) catalyzes a large structural change in the poliovirus that exposes membrane-binding protein chains.
Data show that CD155 protein/CD226 antigen (show CD226 Proteins) mainly mediates the interaction between NK cells and leukemic cells in acute myeloid leukemia (show BCL11A Proteins). To investigate the interaction between leukemic cells
absence of either CD155 or CD226 (show CD226 Proteins) in BALB/c mice causes a profound shift in the Natural Killer T-Cells subtype composition in thymus, expanding the frequency and numbers of iNKT1 cells at the expense of iNKT2 cells, as well as iNKT17 cells.
Results suggest that modulation of the expression of receptors and CD112 (show PVRL2 Proteins) compensates for CD155 deficiency in immune surveillance against methylcholanthrene-induced tumors.
Sertoli cells recognize the excess cytoplasm of elongated spermatids through the PVR (show PVRL2 Proteins)-CEACAM2-L (show CEACAM2 Proteins) interaction in mouse testis
TIGIT (show TIGIT Proteins)/PVR (show PVRL2 Proteins) ligation signaling mediates suppression of IFN-gamma (show IFNG Proteins) production via the NF-kappaB (show NFKB1 Proteins) pathway.
Our data suggest that CD155 regulates T(h)2 differentiation
These observations establish a firm link between the functions of CD155 and CD226 (show CD226 Proteins) in several T cell differentiation steps.
Necl-5/poliovirus receptor interacts with VEGFR2 (show KDR Proteins) and regulates VEGF (show VEGFA Proteins)-induced angiogenesis.
The TLR3 (show TLR3 Proteins)-TRIF (show RNF138 Proteins) mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice.
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.
, nectin-like 5
, nectin-like protein 5
, tumor-associated antigen 1
, tumor-associated glycoprotein pE4