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Human Polyclonal PRAM1 Primary Antibody for WB - ABIN374107
Moog-Lutz, Peterson, Lutz, Eliason, Cavé-Riant, Singer, Di Gioia, Dmowski, Kamens, Cayre, Koretzky: PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells. in The Journal of biological chemistry 2001
A yopH mutant survived better in the absence of neutrophils, indicating that neutrophil inactivation by YopH by targeting PRAM-1/SKAP-HOM (show SKAP2 Antibodies) and SLP-76 (show LCP2 Antibodies)/Vav (show VAV1 Antibodies)/PLCgamma2 (show PLCG2 Antibodies) signaling hubs may be critical for Yersinia survival.
autophagy contributes to the anti-apoptotic function of the PML (show PML Antibodies)-RARalpha (show RARA Antibodies) protein through inhibiting the Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) pathway
Transgenic mice expressing PML-RAR alpha (show RARA Antibodies) develop acute promyelocytic leukemia (show PML Antibodies) with long latency, low penetrance, and acquired cytogenetic abnormalities.
Our results show that the pretreatment PML (show PML Antibodies)-RARA (show RARA Antibodies) molecular burden could therefore be used to improve risk stratification in order to develop more individualized treatment regimens for high-risk APL (show FASL Antibodies) cases.
The 3-plex RT-qPCR assay is a specific, sensitive, stable, and cost-effective method that can be used for the rapid diagnosis and treatment monitoring of acute promyelocytic leukemia (show PML Antibodies) with PML (show PML Antibodies)-RARa (show RARA Antibodies)
The MIR125B1-mediated blockade of PML (show PML Antibodies)-RARA (show RARA Antibodies) proteolysis was regulated via an autophagy-lysosomal pathway, contributing to the inhibition of acute promyelocytic leukemia (show PML Antibodies) differentiation.
PRAM-1 is required for optimal integrin-dependent neutrophil function.
Caspase 3 (show CASP3 Antibodies)-cleaved SH3 domain (show ITSN1 Antibodies) of HIP-55 (show DBNL Antibodies) is likely involved in PRAM-1-mediated JNK (show MAPK8 Antibodies) activation upon arsenic trioxide-induced differentiation of NB4 cells.
The use of reverse-transcription polymerase chain reaction for the detection of the PML (show PML Antibodies)-RARA (show RARA Antibodies) and RARA (show RARA Antibodies)-PML (show PML Antibodies) fusion genes that allow for monitoring of acute myelocytic leukemia.
PML (show PML Antibodies)-RARalpha (show RARA Antibodies) fusion transcripts have been shown to be useful markers for establishing the diagnosis and for monitoring the response to treatment of acute promyelocytic leukemia (show PML Antibodies).
Interaction of PRAM-1 and hSH3 domains of adhesion and degranulation promoting adapter protein (show TOLLIP Antibodies) (ADAP (show FYB Antibodies)) with phosphatidylcholine (show SGMS2 Antibodies)-containing liposomes is observed upon incorporation of phosphatidylserine or phosphoinositides into the membrane bilayer.
hidden abnormalities and novel disease-related genomic changes occur in t(15;17)translocation in acute promyelocytic leukemia (show PML Antibodies) formation of PML (show PML Antibodies)-RARA (show RARA Antibodies) gene
The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha).
PML-RARA regulated adaptor molecule 1
, PML-RARA-regulated adapter molecule 1-like
, PML-RARA-regulated adapter molecule 1
, PML-RARA target gene encoding an Adaptor Molecule-1
, PML-RAR alpha-regulated adaptor molecule 1