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Human Polyclonal SUPT6H Primary Antibody for ChIP, ICC - ABIN4355771
Kronemann, Hagemeier, Cygnar, Phillips, Bresnahan: Binding of the human cytomegalovirus (HCMV) tegument protein UL69 to UAP56/URH49 is not required for efficient replication of HCMV. in Journal of virology 2010
Show all 4 Pubmed References
Human Polyclonal SUPT6H Primary Antibody for IP - ABIN251024
Cygnar, Hagemeier, Kronemann, Bresnahan: The cellular protein SPT6 is required for efficient replication of human cytomegalovirus. in Journal of virology 2012
Drosophila Spt6 (dSpt6) co-purifies with the exosome, a complex of 3' to 5' exoribonucleases that is implicated in the processing of structural RNA and in the degradation of improperly processed pre-mRNA
Data show that Spt6 can modulate the elongation rate of RNA polymerase II (Pol II) on naked or chromatin-reconstituted templates in vitro.
Biochemical as well as functional experiments revealed that Spt6 could compete for binding of the PRC2 methyltransferase Ezh2 (show EZH2 Antibodies) to Suz12 (show SUZ12 Antibodies) and reduce PRC2 chromatin engagement.
These data indicate that, through cooperation with PolII and KDM6A (show KDM6A Antibodies), Spt6 orchestrates removal of H3K27me3, thus controlling developmental gene expression and cell differentiation.
Knockdown of Spt6 resulted in severe reduction of class switch recombination in the endogenous Ig locus in B cells.
Thus binding of Spt6 to Ser2 (show JAG2 Antibodies)-P RNAPII provides a cotranscriptional mechanism to recruit Iws1, REF1/Aly (show THOC4 Antibodies), and associated mRNA processing, surveillance, and export factors to responsive genes.
recombinant Spt6 binds selectively to a stretch of uninterrupted consensus repeats located in the N-terminal half of the CTD and recruits Iws1
The elongation factors Pandora/Spt6 and Foggy/Spt5 (show SUPT5H Antibodies) promote transcription in the zebrafish embryo. (Pandora/Spt6)
Spt6 is essential for the transcriptional response to activation of the Notch (show NOTCH1 Antibodies) pathway.
Altogether, these results indicate that a complex containing LEDGF/p75 (show PSIP1 Antibodies), Iws1, and Spt6 participates in regulating postintegration steps of HIV latency.
identified fibronectin (show FN1 Antibodies), a component of the extracellular matrix and a mesenchymal marker, as a transcriptional target of Pak1 (show PAK1 Antibodies) signaling
Spt6 is a unique histone chaperone capable of regulating the histone epigenetic state of both AID targets and the AID locus.
These results show that intracellular levels of Spt6 are fine-tuned by PAAF1 (show PAAF1 Antibodies) and proteasome, which is required for HIV-1 transcription and extends to cellular genes implicated in cancer.
Abolishing UL69's ability to interact with the SPT6 protein inhibited human cytomegalovirus replication.
Reults establish that human Spt6 (hSpt6) is a classic transcription elongation factor (show TSFM Antibodies) that enhances the rate of RNA polymerase II elongation.
Acts to stimulate transcriptional elongation by RNA polymerase II (By similarity).
, suppressor of Ty 6 homolog (S. cerevisiae)
, suppressor of Ty 6 homolog
, Spt6 gene product
, SUPT6H,-like protein to suppressor of ty 6
, transcription elongation factor SPT6-like
, hypothetical protein
, transcription elongation factor SPT6
, protein pandora
, tat-CT2 protein
, tat-cotransactivator 2 protein