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Human TNFSF13 ELISA Kit for Sandwich ELISA - ABIN414805
Roderburg, Koch, Tacke, Nieuwenhuijsen, Bruensing, Vargas Cardenas, Kreggenwinkel, Vucur, Koppe, Jungebluth, Seikrit, Luedde, Trautwein, Luedde: Serum concentrations of A Proliferation-Inducing Ligand (APRIL) are elevated in sepsis and predict mortality in critically ill patients. in Journal of critical care 2013
BCMA (show TNFRSF17 ELISA Kits) has other contributors for ligands binding except DxL motif. The affinity of BCMA (show TNFRSF17 ELISA Kits) for APRIL higher than for BAFF (show TNFSF13B ELISA Kits) may be caused by the segment outside of the conservative DxL motif. Moreover, the exposition of new binding modes of BCMA2 interacting with APRIL may establish the foundation of designing novel drugs in the future
ApoE-/-APRIL-Tg mice have increased oxLDL-specific serum IgM levels, potentially mediated via an increase in B1a lymphocytes
Results showed that chemokine (show CCL1 ELISA Kits)-mediated recruitment of neutrophils secreting the tumor-promoting factor APRIL mediates DLBCL progression.
This study showed that both BAFF (show TNFSF13B ELISA Kits) and APRIL levels were increased in CSF (show CSF2 ELISA Kits) of patients with anti-NMDAR (show GRIN1 ELISA Kits) encephalitis.
New molecular mechanisms of in vivo Multiple Myeloma (MM) growth and immunosuppression critically dependent on BCMA (show TNFRSF17 ELISA Kits) and APRIL in the Bone marrow microenvironment, further supporting targeting this prominent pathway in MM.
Urinary APRIL (uAPRIL) and BAFF (show TNFSF13B ELISA Kits) (uBAFF) levels were raised significantly in AN.
Data did not detect any significant association with SNPs of APRIL, SPATA8, PDGFRA, and POLB with Systemic Lupus Erythematosus in Chinese Han Population.
Recombinant human APRIL (rhAPRIL) could rescue HCC (show FAM126A ELISA Kits) cell proliferation inhibited by miR (show MLXIP ELISA Kits)-383.
Host-derived proteins pp32 and APRIL interact with a free form of influenza virus RNA-dependent RNA polymerase and preferentially upregulates viral RNA synthesis rather than cRNA synthesis.
high expression of APRIL in clear cell renal cell carcinoma was correlated with high Fuhrman nuclear grade, high pathologic stage, and poor overall and cancer-specific survival of the patients
this study identifies APRIL as a new target involved in B-cell activation (show BLNK ELISA Kits), in the maintenance of plasma cell survival and subsequent increased autoantibody production that sustains lupus development in mice
this is the first study to implicate the APRIL signal transduction pathway in the pathogenesis of nephrogenic IgA production. Moreover, our findings identify APRIL as a potential target of therapy.
the elevated presence of APRIL and BLyS (show TNFSF13B ELISA Kits) in B cell-rich areas of chronically inflamed gingiva suggests that these cytokines may contribute to bone loss by promoting the survival and persistence of RANKL (show TNFSF11 ELISA Kits)-expressing B cells/plasma cells.
B cell activating factor (BAFF (show TNFSF13B ELISA Kits)) and a proliferation inducing ligand (APRIL) mediate CD40 (show CD40 ELISA Kits)-independent help by memory CD4 (show CD4 ELISA Kits) T cells in transplantations.
Heteromers consisting of one BAFF (show TNFSF13B ELISA Kits) and two APRIL bind to receptor TACI (show TNFRSF13B ELISA Kits), BCMA (show TNFRSF17 ELISA Kits) but not to BAFFR (show TNFRSF13C ELISA Kits).
Immunization of mice with a DNA vaccine encoding BAFF or APRIL multitrimers, together with interleukin 12 and membrane-bound HIV-1 Env gp140, induced neutralizing antibodies against tier 1 and tier 2 (vaccine strain) viruses.
APRIL selectively enhances axonal growth by activating ERK (show EPHB2 ELISA Kits) signaling and PI3-kinase (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits)/GSK-3beta (show GSK3b ELISA Kits) signaling.
Data indicate that APRIL expression accelerates the onset of TCL1 (show TCL1A ELISA Kits)-driven leukemia formation mainly through TACI (show TNFRSF13B ELISA Kits) activation.
The ability of TACI (show TNFRSF13B ELISA Kits)-Fc to activate reverse signalling through BAFF (show TNFSF13B ELISA Kits) and APRIL, was investigated.
CD1d (show CD1D ELISA Kits)-restricted invariant NKT (show CTSL1 ELISA Kits) cell-derived BAFF (show TNFSF13B ELISA Kits) and APRIL each contribute to survival of plasma cells induced by immunization.
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified\; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
tumor necrosis factor ligand superfamily member 13
, tumor necrosis factor ligand superfamily member 13 isoform alpha proprotein
, SLAN protein
, Acidic leucine-rich nuclear phosphoprotein 32 family member B
, TNF superfamily member 13
, TNFSF12-TNFSF13 readthrough transcript
, tumor necrosis factor superfamily member 13
, tumor necrosis factor (ligand) superfamily, member 13
, TNF- and APOL-related leukocyte expressed ligand 2
, a proliferation-inducing ligand
, tumor necrosis factor-like protein ZTNF2
, tumor necrosis factor-related death ligand-1
, A proliferation-inducing ligand