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Zebrafish Abcb4 plays crucial roles in cellular efflux of microcystin-LR and is a potential molecular marker for the monitoring of cyanobacteria contamination in the aquatic environment.
In the rabbit cornea, the expression and activity of MDR1 transporter was confirmed, whereas human cell culture models and porcine corneas did not show MDR1 expression
MDR1A deficiency restrains tumor growth in murine colitis-associated carcinogenesis.
multiple pathways, including MMP9 (show MMP9 ELISA Kits) cleavage and ubiquitinylation, mediated P-gp downmodulation.
Data suggest that MDR3 isoforms, both human and mouse isoforms, exhibit different affinities for fluorescent dyes and drugs; thus, ligands likely occupy partially overlapping but distinct binding sites.
using double electron-electron resonance and molecular dynamics simulations to describe the ATP- and substrate-coupled conformational cycle of the mouse ABC (show ABCB6 ELISA Kits) efflux transporter P-glycoprotein (Pgp; also known as ABCB1 (show ABCB1 ELISA Kits))
Mdr1a deficiency significantly enhanced the analgesic effect of aconitine and exacerbated its toxicity in the brain.
Chrysosplenetin inhibited P-gp activity and reverse the up-regulated P-gp and MDR1 levels induced by artemisinin.
Tamsulosin and tolterodine with P-gp gene expression and activity in an enantiomer-specific way.
These results indicate that nilotinib reverses P-gp- mediated MDR by blocking the efflux function and potentiates DOX-induced cardiotoxicity.
Results indicate that Abeta (show APP ELISA Kits) accumulates to a greater degree in brains of mice lacking MDR1A
[(18)F]Mefway is modulated by P-gp, and not by Bcrp (show ABCG2 ELISA Kits) in rodents.
results are suggestive of a potential downstream molecular effect for the described polymorphisms on the expression pattern of the ABCB4 underlining the importance of synonymous variants
the first characterisation at the protein level of six ABCB4 variants (D243A, K435T, G535D, I490T, R545C, and S978P) previously found in patients with inflammatory liver diseases or liver cancer, is reported.
Ivacaftor is a potential therapy for selected patients with cystic fibrosis (show S100A8 ELISA Kits) with mutations of ABCB4.
Data show that patients with low multidrug resistance protein 3 (MDR3) expression were significantly associated with a better outcome than patients with high MDR3 expression.
In patients with intrahepatic cholestasis of pregnancy, ABCB4 gene mutation was not associated with response to ursodeoxycholic acid treatment.
Single-nucleotide polymorphism in ABCB4 gene is associated with gallbladder cancer.
the cholestatic potential of certain drugs may be aggravated by simultaneous inhibition of BSEP (show ABCB11 ELISA Kits) and MDR3.
Negative immunoreaction of MDR3 was found in the majority of the progressive familial intrahepatic cholestasis (PFIC (show ATP8B1 ELISA Kits)) group. Nonetheless, the negative immunoreaction was demonstrated in a considerable number of the non-PFIC (show ATP8B1 ELISA Kits) group. Negative MDR3 immunoreaction was more frequently associated with PFIC3 compared to non-PFIC (show ATP8B1 ELISA Kits) group.
Exons 6, 8 and 9 mutations of ABCB4 gene are not common among Egyptian children with Progressive Familial Intrahepatic Cholestasis type 3.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined\; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.
ATP-binding cassette, sub-family B (MDR/TAP), member 4
, ATP-binding cassette, subfamily B, member 4
, ABC transporter protein
, ATP-binding cassette, sub-family B (MDR/TAP), member 1
, ATP-binding cassette, subfamily B, member 1
, member 1
, member 4
, multidrug resistance protein 1
, sub-family B (MDR/TAP)
, subfamily B
, P glycoprotein 3/ multiple drug resistance 3
, ABC efflux transporter 4
, multidrug resistance protein 3-like
, multidrug resistance protein 3
, ATP-binding cassette transporter protein
, multi-drug resistance P-glycoprotein 1
, ATP-binding cassette sub-family B member 1A
, ATP-binding cassette, subfamily B, member 1A
, P glycoprotein 3
, P-glycoprotein 3
, ecotropic viral integration site 32
, multi-drug resistance 3
, multidrug resistance protein 1A
, multiple drug resistant 1a
, P-glycoprotein 2
, multidrug resistance protein 2
, ATP-binding cassette sub-family B member 4
, P glycoprotein 3/multiple drug resistance 3
, P-glycoprotein-3/multiple drug resistance-3
, multiple drug resistance 3
, P glycoprotein 2
, multidrug resistance 3
, p-glycoprotein isoform III
, ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2
, ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2)
, ATP-binding cassette, sub-family B (MDR/TAP), member 4 (P-glycoprotein 3/ multidrug resistance 2)
, P-glycoprotein 3/ multidrug resistance 2