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Several members of a family exhibited cholestasis and were found to have a substitution of glycine 68 by arginine in ABCB4 due to a missense mutation at base 202. The 18-year-old propositus was heterozygous for this mutation and also suffered acute pancreatitis.
ABCB4 variants identified in patients with biliary diseases
results are suggestive of a potential downstream molecular effect for the described polymorphisms on the expression pattern of the ABCB4 underlining the importance of synonymous variants
the first characterisation at the protein level of six ABCB4 variants (D243A, K435T, G535D, I490T, R545C, and S978P) previously found in patients with inflammatory liver diseases or liver cancer, is reported.
Ivacaftor is a potential therapy for selected patients with cystic fibrosis (show S100A8 Proteins) with mutations of ABCB4.
Data show that patients with low multidrug resistance protein 3 (MDR3) expression were significantly associated with a better outcome than patients with high MDR3 expression.
In patients with intrahepatic cholestasis of pregnancy, ABCB4 gene mutation was not associated with response to ursodeoxycholic acid treatment.
Data suggest that MDR3 isoforms, both human and mouse isoforms, exhibit different affinities for fluorescent dyes and drugs; thus, ligands likely occupy partially overlapping but distinct binding sites.
Single-nucleotide polymorphism in ABCB4 gene is associated with gallbladder cancer.
the cholestatic potential of certain drugs may be aggravated by simultaneous inhibition of BSEP (show ABCB11 Proteins) and MDR3.
In the rabbit cornea, the expression and activity of MDR1 transporter was confirmed, whereas human cell culture models and porcine corneas did not show MDR1 expression
These results provide evidence that zebrafish Pxr (show NR1I2 Proteins) may play a role in MDR/MXR through transcriptional regulation of abcb4 and cyp3a65 gene expression.
Zebrafish Abcb4 plays crucial roles in cellular efflux of microcystin-LR and is a potential molecular marker for the monitoring of cyanobacteria contamination in the aquatic environment.
These data confirm that seliciclib displays a limited brain exposure and Abcb1a is at least partly responsible for limited brain exposure of seliciclib in mice.
Data suggest that, in the presence of verapamil (a substrate that activates ATP hydrolysis), the nucleotide-binding domains of Abcb1a (reconstituted in lipid bilayer nanodiscs) are never far apart during cycle of ATP hydrolysis.
MDR1A deficiency restrains tumor growth in murine colitis-associated carcinogenesis.
multiple pathways, including MMP9 (show MMP9 Proteins) cleavage and ubiquitinylation, mediated P-gp downmodulation.
using double electron-electron resonance and molecular dynamics simulations to describe the ATP- and substrate-coupled conformational cycle of the mouse ABC (show ABCB6 Proteins) efflux transporter P-glycoprotein (Pgp; also known as ABCB1 (show ABCB1 Proteins))
Mdr1a deficiency significantly enhanced the analgesic effect of aconitine and exacerbated its toxicity in the brain.
Chrysosplenetin inhibited P-gp activity and reverse the up-regulated P-gp and MDR1 levels induced by artemisinin.
Tamsulosin and tolterodine with P-gp gene expression and activity in an enantiomer-specific way.
These results indicate that nilotinib reverses P-gp- mediated MDR by blocking the efflux function and potentiates DOX-induced cardiotoxicity.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined\; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.
ATP-binding cassette sub-family B member 4
, P glycoprotein 3/multiple drug resistance 3
, P-glycoprotein 3
, P-glycoprotein-3/multiple drug resistance-3
, multidrug resistance protein 3
, multiple drug resistance 3
, multi-drug resistance P-glycoprotein 1
, multidrug resistance protein 1
, ABC efflux transporter 4
, ATP-binding cassette, sub-family B (MDR/TAP), member 4
, ATP-binding cassette, subfamily B, member 4
, multidrug resistance 3
, ATP-binding cassette, sub-family B (MDR/TAP), member 1
, member 4
, sub-family B (MDR/TAP)
, ABC transporter protein
, ATP-binding cassette, subfamily B, member 1
, member 1
, subfamily B
, P glycoprotein 2
, multidrug resistance protein 2
, ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2
, ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2)
, ATP-binding cassette, sub-family B (MDR/TAP), member 4 (P-glycoprotein 3/ multidrug resistance 2)
, P-glycoprotein 2
, P-glycoprotein 3/ multidrug resistance 2
, multidrug resistance protein 3-like
, ATP-binding cassette transporter protein
, ATP-binding cassette sub-family B member 1A
, ATP-binding cassette, subfamily B, member 1A
, P glycoprotein 3
, ecotropic viral integration site 32
, multi-drug resistance 3
, multidrug resistance protein 1A
, multiple drug resistant 1a
, Beta-defensin 1
, Defensin, beta 1
, p-glycoprotein isoform III
, LOW QUALITY PROTEIN: phosphatidylcholine translocator ABCB4
, RUN domain containing 3B
, RUN domain-containing protein 3B
, phosphatidylcholine translocator ABCB4
, P glycoprotein 3/ multiple drug resistance 3