Browse our ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 Proteins (ABCB4)

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ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 Proteins (ABCB4)
On www.antibodies-online.com are 16 ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4) Proteins from 4 different suppliers available. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 Antibodies (57) and ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 Kits (10) and many more products for this protein. A total of 88 ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 products are currently listed.
Synonyms:
ABC20, ABC21, ABCB1, Abcb4, ABCB4a, CMDR1, Evi32, GBD1, GP170, ICP3, mdr-2, mdr-3, MDR1, Mdr1a, Mdr2, MDR2/3, MDR3, P-gp, PFIC-3, Pgp, PGP2, PGP3, Pgy-2, Pgy-3, PGY1, Pgy2, Pgy3, zgc:172149
list all proteins Gene Name GeneID UniProt
ABCB4 18671 P21447
ABCB4 5244 P21439
Rat ABCB4 ABCB4 24891 Q08201

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ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 Proteins (ABCB4) by Origin

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More Proteins for ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 Interaction Partners

Zebrafish ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4) interaction partners

  1. Zebrafish Abcb4 plays crucial roles in cellular efflux of microcystin-LR and is a potential molecular marker for the monitoring of cyanobacteria contamination in the aquatic environment.

Rabbit ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4) interaction partners

  1. In the rabbit cornea, the expression and activity of MDR1 transporter was confirmed, whereas human cell culture models and porcine corneas did not show MDR1 expression

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4) interaction partners

  1. MDR1A deficiency restrains tumor growth in murine colitis-associated carcinogenesis.

  2. multiple pathways, including MMP9 (show MMP9 Proteins) cleavage and ubiquitinylation, mediated P-gp downmodulation.

  3. Data suggest that MDR3 isoforms, both human and mouse isoforms, exhibit different affinities for fluorescent dyes and drugs; thus, ligands likely occupy partially overlapping but distinct binding sites.

  4. using double electron-electron resonance and molecular dynamics simulations to describe the ATP- and substrate-coupled conformational cycle of the mouse ABC (show ABCB6 Proteins) efflux transporter P-glycoprotein (Pgp; also known as ABCB1 (show ABCB1 Proteins))

  5. Mdr1a deficiency significantly enhanced the analgesic effect of aconitine and exacerbated its toxicity in the brain.

  6. Chrysosplenetin inhibited P-gp activity and reverse the up-regulated P-gp and MDR1 levels induced by artemisinin.

  7. Tamsulosin and tolterodine with P-gp gene expression and activity in an enantiomer-specific way.

  8. These results indicate that nilotinib reverses P-gp- mediated MDR by blocking the efflux function and potentiates DOX-induced cardiotoxicity.

  9. Results indicate that Abeta (show APP Proteins) accumulates to a greater degree in brains of mice lacking MDR1A

  10. [(18)F]Mefway is modulated by P-gp, and not by Bcrp in rodents.

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4) interaction partners

  1. results are suggestive of a potential downstream molecular effect for the described polymorphisms on the expression pattern of the ABCB4 underlining the importance of synonymous variants

  2. the first characterisation at the protein level of six ABCB4 variants (D243A, K435T, G535D, I490T, R545C, and S978P) previously found in patients with inflammatory liver diseases or liver cancer, is reported.

  3. Ivacaftor is a potential therapy for selected patients with cystic fibrosis (show S100A8 Proteins) with mutations of ABCB4.

  4. Data show that patients with low multidrug resistance protein 3 (MDR3) expression were significantly associated with a better outcome than patients with high MDR3 expression.

  5. In patients with intrahepatic cholestasis of pregnancy, ABCB4 gene mutation was not associated with response to ursodeoxycholic acid treatment.

  6. Data suggest that MDR3 isoforms, both human and mouse isoforms, exhibit different affinities for fluorescent dyes and drugs; thus, ligands likely occupy partially overlapping but distinct binding sites.

  7. Single-nucleotide polymorphism in ABCB4 gene is associated with gallbladder cancer.

  8. the cholestatic potential of certain drugs may be aggravated by simultaneous inhibition of BSEP (show ABCB11 Proteins) and MDR3.

  9. Negative immunoreaction of MDR3 was found in the majority of the progressive familial intrahepatic cholestasis (PFIC (show ATP8B1 Proteins)) group. Nonetheless, the negative immunoreaction was demonstrated in a considerable number of the non-PFIC (show ATP8B1 Proteins) group. Negative MDR3 immunoreaction was more frequently associated with PFIC3 compared to non-PFIC (show ATP8B1 Proteins) group.

  10. Exons 6, 8 and 9 mutations of ABCB4 gene are not common among Egyptian children with Progressive Familial Intrahepatic Cholestasis type 3.

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4) Protein Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined\; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.

Alternative names and synonyms associated with ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4)

  • ATP-binding cassette, sub-family B (MDR/TAP), member 5 (abcb5)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1-like B (ABCB1LB)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1-like A (ABCB1LA)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 4 (ABCB4)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 4 (abcb4)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1A (Abcb1a)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 4 (Abcb4)
  • ATP-binding cassette, subfamily B (MDR/TAP), member 4 (Abcb4)
  • ABC20 protein
  • ABC21 protein
  • ABCB1 protein
  • Abcb4 protein
  • ABCB4a protein
  • CMDR1 protein
  • Evi32 protein
  • GBD1 protein
  • GP170 protein
  • ICP3 protein
  • mdr-2 protein
  • mdr-3 protein
  • MDR1 protein
  • Mdr1a protein
  • Mdr2 protein
  • MDR2/3 protein
  • MDR3 protein
  • P-gp protein
  • PFIC-3 protein
  • Pgp protein
  • PGP2 protein
  • PGP3 protein
  • Pgy-2 protein
  • Pgy-3 protein
  • PGY1 protein
  • Pgy2 protein
  • Pgy3 protein
  • zgc:172149 protein

Protein level used designations for ABCB4

ATP-binding cassette, sub-family B (MDR/TAP), member 4 , ATP-binding cassette, subfamily B, member 4 , ABC transporter protein , ATP-binding cassette, sub-family B (MDR/TAP), member 1 , ATP-binding cassette, subfamily B, member 1 , member 1 , member 4 , multidrug resistance protein 1 , sub-family B (MDR/TAP) , subfamily B , P glycoprotein 3/ multiple drug resistance 3 , ABC efflux transporter 4 , abcb1b , multidrug resistance protein 3-like , multidrug resistance protein 3 , ATP-binding cassette transporter protein , multi-drug resistance P-glycoprotein 1 , ATP-binding cassette sub-family B member 1A , ATP-binding cassette, subfamily B, member 1A , P glycoprotein 3 , P-glycoprotein 3 , ecotropic viral integration site 32 , multi-drug resistance 3 , multidrug resistance protein 1A , multiple drug resistant 1a , P-glycoprotein 2 , multidrug resistance protein 2 , ATP-binding cassette sub-family B member 4 , P glycoprotein 3/multiple drug resistance 3 , P-glycoprotein-3/multiple drug resistance-3 , multiple drug resistance 3 , P glycoprotein 2 , multidrug resistance 3 , p-glycoprotein isoform III , ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2 , ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2) , ATP-binding cassette, sub-family B (MDR/TAP), member 4 (P-glycoprotein 3/ multidrug resistance 2) , P-glycoprotein 3/ multidrug resistance 2

GENE ID SPECIES
394865 Xenopus (Silurana) tropicalis
395712 Gallus gallus
420534 Gallus gallus
748364 Pan troglodytes
756756 Strongylocentrotus purpuratus
783154 Bos taurus
100136865 Danio rerio
100354947 Oryctolagus cuniculus
100398854 Callithrix jacchus
100455534 Pongo abelii
100462975 Monodelphis domestica
100475375 Ailuropoda melanoleuca
100008914 Oryctolagus cuniculus
18671 Mus musculus
100682537 Cricetulus griseus
5244 Homo sapiens
18670 Mus musculus
482284 Canis lupus familiaris
100144586 Sus scrofa
100336338 Bos taurus
100682535 Cricetulus griseus
24891 Rattus norvegicus
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