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Study identified a genetic variant in the 3'-UTR region of ACSL1 gene (rs8086) that may play a significant role in predicting outcomes of stage II/III patients with colon cancer, so that patients with T/T genotype had a significantly higher risk of tumor recurrence than those carrying at least one C allele.
The mRNA levels of ACSL1 were positively associated with those of HBXIP (show HBXIP Proteins) in clinical breast cancer tissues. Thus, we conclude that the oncoprotein HBXIP (show HBXIP Proteins) is able to up-regulate ACSL1 through activating the transcriptional factor Sp1 (show PSG1 Proteins) in breast cancer.
evidence in humans of ACSL1 SNPs associated with fasting glucose, diabetes, and subclinical atherosclerosis
SRE motif in ACSL1 is essential for SREBP2 (show SREBF2 Proteins)-mediated activation of C-ACSL1 gene transcription.
ACSL1 is a programmable mediator of insulin (show INS Proteins) sensitivity and cellular lipid content.
the cell surface protein (show CD28 Proteins) CD36 (show CD36 Proteins)/FAT directly facilitates fatty acid transport across the plasma membrane, whereas the intracellular acyl-CoA (show GNPAT Proteins) synthetases FATP4 (show SLC27A4 Proteins) and ACSL1 enhance fatty acid uptake indirectly by metabolic trapping
Data indicate that expression of miR-205 is negatively related to that of ACSL1 in clinical hepatocellular carcinoma (HCC) tissues.
INSR rs1366600, ACSL1 rs2292899 and FABP2 rs11724758 could influence the susceptibility to type 2 diabetes in Chinese Han population, most likely through their effects on the specific miRNA-binding sites.
long-chain acyl-CoA synthetase 1 has a role in eicosapentaenoic acid suppression of palmitate-induced cytokine production
Findings suggest that the ACSL1 gene polymorphism rs6552828 is not associated with elite endurance athletic status in Caucasians, yet a marginal association seems to exist for the Chinese (Han) male population.
The pig ACSL1 gene expresses differently in different tissues and pig breeds.
Authors have sequenced 3,013 bp of the pig acyl coenzyme A (show SOAT1 Proteins) long-chain synthetase 1 (ACSL1) gene.
The initial QTL analysis suggested the ACSL1 gene as a candidate gene for fatty acid composition in bovine skeletal muscle; subsequent analyses indicate that ACSL1 or a gene in close proximity plays a functional role in the lipid composition of beef.
The results of this study suggest that suggest that SLC27A6, ACSL1, FABP3 (show FABP3 Proteins), AGPAT6 (show AGPAT6 Proteins), and LPIN1 (show LPIN1 Proteins) coordinately regulate the channeling of fatty acids toward copious milk fat synthesis in bovine mammary.
ACSL1-mediated metabolic trapping of exogenous LCFA accelerates LCFA uptake rates, albeit to a lesser extent in females, which distinctly affects LCFA trafficking to acyl intermediates but not triglyceride storage or mitochondrial oxidation and is affected by female sex hormones.
Data (including data from studies in cell line from knockout mice) suggest high incorporation of long-chain fatty acids, partly mediated by Acsl1, plays role in supply of octanoic acid for ghrelin (show GHRL Proteins) acylation/lipoylation in ghrelin (show GHRL Proteins)-producing cells.
Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function
long-chain acyl-CoA synthetase (show Acsl3 Proteins) isoform 1 (ACSL1) deficiency in the heart activated mTORC1, thereby inhibiting autophagy and increasing the number of damaged mitochondria.
Acsl1(M-/-) mice were more insulin (show INS Proteins) sensitive, and, during an overnight fast, their respiratory exchange ratio was higher, indicating greater glucose use and during endurance exercise, Acsl1(M-/-) mice ran only 48% as far as controls.
These data indicate that Acsl1-deficiency causes diastolic dysfunction and that mTOR (show FRAP1 Proteins) activation is linked to the development of cardiac hypertrophy in Acsl1(H-/-) mice.
Data indicate that the expression levels of ACSL1 and its metabolite triglyceride levels were remarkably increased in hepatitis B virus X protein (HBx)-induced liver cancer tissues from the HBx transgenic mice model.
Increases understanding of the role of ACSL1 in monocytes/macrophages in inflammation and diabetes-accelerated atherosclerosis offers hope for new treatment to combat diabetic vascular disease[review]
Acyl-CoA synthetase 1 is induced by Gram-negative bacteria and lipopolysaccharide and is required for phospholipid turnover in stimulated macrophages
The combined inactivation of LACS1 and LACS4 (show ACSL4 Proteins) in Arabidopsis resulted in conditional pollen sterility and impaired wax biosynthesis.
LACS1 is localized in the ER and functionally overlaps with LACS9 to supply acyl-CoAs for TAG biosynthesis.
Both ABA and LRD2 control root system architecture in the presence or absence of osmotic stress in A. thaliana. [LRD2]
lacs1 lacs2 double-mutant plants displayed pleiotropic phenotypes including organ fusion, abnormal flower development and reduced seed set.
LACS1 is a functionally novel acyl-CoA synthetase that preferentially modifies both VLCFAs for wax synthesis and long-chain (C16) fatty acids for cutin synthesis.
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation.
long-chain-fatty-acid-CoA ligase 1
, LACS 1
, LACS 2
, acyl-CoA synthetase 1
, fatty-acid-Coenzyme A ligase, long-chain 1
, fatty-acid-Coenzyme A ligase, long-chain 2
, lignoceroyl-CoA synthase
, long-chain acyl-CoA synthetase 1
, long-chain acyl-CoA synthetase 2
, long-chain fatty acid-CoA ligase 2
, long-chain fatty-acid-coenzyme A ligase 1
, long-chain-fatty-acid--CoA ligase 1
, palmitoyl-CoA ligase 1
, palmitoyl-CoA ligase 2
, paltimoyl-CoA ligase 1
, acyl coenzyme A synthetase long-chain 1
, fatty acid coenzyme A ligase long-chain 2
, acetate-CoA ligase
, acetyl-CoA synthetase
, acetyl-Coenzyme A synthetase 1 (ADP forming)
, fatty acid Coenzyme A ligase, long chain 2
, Acyl CoA synthetase, long chain
, long-chain-fatty-acid--CoA ligase, liver isozyme
, palmitoyl-CoA ligase