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Browse our anti-ALAS1 (ALAS1) Antibodies

Full name:
anti-Aminolevulinate, delta-, Synthase 1 Antibodies (ALAS1)
On www.antibodies-online.com are 53 Aminolevulinate, delta-, Synthase 1 (ALAS1) Antibodies from 17 different suppliers available. Additionally we are shipping ALAS1 Kits (15) and ALAS1 Proteins (5) and many more products for this protein. A total of 77 ALAS1 products are currently listed.
Synonyms:
ALAS, Alas-1, Alas-h, ALAS-N, ALAS1, ALAS3, ALASH, ALASN, MIG4, wu:fb58d01, wu:fi12g09
list all antibodies Gene Name GeneID UniProt
ALAS1 100420897  
ALAS1 65155 P13195
ALAS1 11655 Q8VC19

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anti-Human ALAS1 Antibodies:

anti-Rat (Rattus) ALAS1 Antibodies:

anti-Mouse (Murine) ALAS1 Antibodies:

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Top referenced anti-ALAS1 Antibodies

  1. Human Polyclonal ALAS1 Primary Antibody for IHC (p), SimWes - ABIN252387 : Zheng, Shan, Lambrecht, Donohue, Bonkovsky: Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrin. in Molecular and cellular biochemistry 2008 (PubMed)
    Show all 3 references for ABIN252387

  2. Chicken Polyclonal ALAS1 Primary Antibody for WB - ABIN2785663 : Jung, Ohl, Stephan, Rabien, Kristiansen, Radonić, Loening, Jung: [Quantifying gene expression in prostate carcinoma. Which endogenous reference genes are suitable?]. in Der Urologe. Ausg. A 2007 (PubMed)

  3. Human Monoclonal ALAS1 Primary Antibody for ELISA, WB - ABIN559839 : Leick, Wojtaszewski, Johansen, Kiilerich, Comes, Hellsten, Hidalgo, Pilegaard: PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle. in American journal of physiology. Endocrinology and metabolism 2008 (PubMed)

More Antibodies against ALAS1 Interaction Partners

Human Aminolevulinate, delta-, Synthase 1 (ALAS1) interaction partners

  1. ALAS1 mRNA and activity were elevated approximately ~3- and 5-fold, and HMB synthase activity was approximately half-normal (~42%)

  2. These results indicate that ALAS1 is a novel NR5A-target gene and participates in steroid hormone production.

  3. Lon (show LONP1 Antibodies) peptidase 1 (show CNDP2 Antibodies) (LONP1 (show LONP1 Antibodies))-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells.

  4. REVIEW: mechanisms involving ALAS deficiency, point mutations, post translational processing, and complex formation with succinyl CoA (show OXCT1 Antibodies) synthetase subunit B in the pathogenesis of hereditary sideroblastic anemia.

  5. ALAS expression is regulated by AP-1 (show FOSB Antibodies) complex through sequestration of cAMP-response element protein (CRE)-binding protein (CBP (show CREBBP Antibodies)) coactivator in human cells

  6. ALAS gene expression is regulated by Hepatic nuclear factor 3 and nuclear factor 1

  7. First described frameshift ALAS2 (show ALAS2 Antibodies) mutation, CD506-507 (-C).

  8. in the liver of Acute liver failure patients, there may be an increase in free heme concentration which down-regulating ALAS1 gene expression

  9. Alternative splicing of human ALAS1 generates two mRNAs with different 5'-UTRs: a major one, where exon 1B is omitted, and a minor form containing exon 1B.

  10. 5-aminolevulinate synthase gene repression by the potent tumor promoter, TPA (show PLAT Antibodies), involves multiple signal transduction pathways

Mouse (Murine) Aminolevulinate, delta-, Synthase 1 (ALAS1) interaction partners

  1. RNAi-mediated silencing of hepatic Alas1 effectively prevents and treats the induced acute attacks in acute intermittent porphyria mice.

  2. Both ALAS1 mRNA and protein content were induced in diabetic animals, accompanied by decreased Akt (show AKT1 Antibodies) phosphorylation and increased nuclear FOXO1 (show FOXO1 Antibodies), PGC-1alpha (show PPARGC1A Antibodies) and FOXO1 (show FOXO1 Antibodies)-PGC-1alpha (show PPARGC1A Antibodies) complex levels.

  3. Egr-1 (show EGR1 Antibodies) regulates the transcriptional repression of mouse delta-aminolevulinic acid synthase 1 by heme

  4. Mice bearing a homozygous knock-in allele were lethal by embryonic day 8.5, demonstrating that ALAS-N is essential for early embryogenesis.

  5. Ser (show SIGLEC1 Antibodies)-254 is critical for formation of a competent catalytic complex by coupling succinyl-CoA (show OXCT1 Antibodies) binding to enzyme conformational equilibria

  6. identified a drug-responsive enhancer in the ALAS1 gene

  7. Histidine-282 impacts a variety of ALAS functions, including substrate and pyridoxal 5'-phosphate (PLP (show C3 Antibodies))-binding and catalysis.

  8. The findings show that a B2 SINE retrotransposon can contribute to the regulation of ALAS1 and SINEs in 5'-UTR (show UTS2R Antibodies) regions contribute to inter-individual differences in gene expression.

ALAS1 Antigen Profile

Antigen Summary

This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme\; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Alternative names and synonyms associated with ALAS1

  • aminolevulinate, delta-, synthase 1 (ALAS1) antibody
  • aminolevulinate, delta-, synthase 1 (alas1) antibody
  • alanyl-tRNA synthetase domain-containing protein (alaS1) antibody
  • alanyl-tRNA synthetase protein (alaS1) antibody
  • aminolevulinate, delta-, synthase 1 pseudogene (ALAS1) antibody
  • aminolevulinate, delta-, synthase 1 pseudogene (LOC100420897) antibody
  • aminolevulinate, delta-, synthase 1 (Alas1) antibody
  • aminolevulinate, delta-, synthetase 1 (alas1) antibody
  • aminolevulinic acid synthase 1 (Alas1) antibody
  • ALAS antibody
  • Alas-1 antibody
  • Alas-h antibody
  • ALAS-N antibody
  • ALAS1 antibody
  • ALAS3 antibody
  • ALASH antibody
  • ALASN antibody
  • MIG4 antibody
  • wu:fb58d01 antibody
  • wu:fi12g09 antibody

Protein level used designations for ALAS1

aminolevulinate, delta, synthase 1 , 5-aminolevulinate synthase, nonspecific, mitochondrial , aminolevulinate, delta-, synthase 1 , 5-aminolevulinic acid synthase 1 , Delta-ALA synthetase , delta-ALA synthase 1 , delta-aminolevulinate synthase 1 , 5-aminolevulinate synthase 1 , 5-aminolevulinate synthase, nonspecific, mitochondrial-like , alanyl-tRNA synthetase domain-containing protein , alanyl-tRNA synthetase protein , 5-aminolevulinic acid synthase , ALAS-H , migration-inducing protein 4 , delta-ALA synthetase 1 , ALA-S , ALAS-N , aminolevulinic acid synthase 1 , delta-ALA synthetase , ALA-synthase , aminolevulinate synthase 1 , aminolevulinate synthase H , succinyl-CoA: glycine C-succinyl transferase

GENE ID SPECIES
460416 Pan troglodytes
493434 Xenopus (Silurana) tropicalis
698093 Macaca mulatta
100031030 Monodelphis domestica
100060491 Equus caballus
100172808 Pongo abelii
100231674 Taeniopygia guttata
100345847 Oryctolagus cuniculus
100388038 Callithrix jacchus
100473179 Ailuropoda melanoleuca
100607410 Nomascus leucogenys
5821016 Bordetella petrii DSM 12804
6399949 Rhizobium etli CIAT 652
100307125 Sus scrofa
100420897 Homo sapiens
444480 Xenopus laevis
211 Homo sapiens
476600 Canis lupus familiaris
534286 Bos taurus
65155 Rattus norvegicus
552895 Gallus gallus
101112853 Ovis aries
64608 Danio rerio
11655 Mus musculus
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