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Human APOA5 Protein expressed in Wheat germ - ABIN1345336
Guardiola, Alvaro, Vallvé, Rosales, Solà, Girona, Serra, Duran, Esteve, Masana, Ribalta: APOA5 gene expression in the human intestinal tissue and its response to in vitro exposure to fatty acid and fibrate. in Nutrition, metabolism, and cardiovascular diseases : NMCD 2012
The minor alleles of rs662799 (APOA5) and rs5072 (APOA1 (show APOA1 Proteins)) modulate TG levels in Mexican children
Rare variants in LPL (show LCP1 Proteins) and a common variant in APOA5 were more commonly found in Thai subjects with severe hypertriglyceridemia
Collectively, these data demonstrate that APOA5 SNP rs651821 might be an important host genetic factor in determining the abundances of the health-promoting Bifidobacterium bacteria and the taxa to which this genus belongs.
Data suggest that estrogen up-regulates serum concentrations of APOA5 and subsequently decreases serum triglyceride levels; APOA5 levels are higher in woman than in men, and the negative relationship between APOA5 and serum triglyceride levels is more significant in woman.
Methylation in exon 3 of APOA5 and epigenetic variability are associated with high circulating triacylglycerol levels.
the lead variant was the rs1558861 [1.99 (1.73-2.30); p = 7.37 x 10(-22) ], residing on chromosome (chr) 11 at the apolipoprotein A-I (show APOA1 Proteins)/A-5 (APOA1 (show APOA1 Proteins)/APOA5) locus
The single nucleotide polymorphisms in lipoprotein lipase (show LPL Proteins), ApoA5, and CETP (show CETP Proteins) were associated with serum triglycerides and HDL (show HSD11B1 Proteins)-cholesterol levels, but not with coronary artery disease in Pakistani population under study.
ur data indicate that the APOA5 rs662799 polymorphism is associated with dyslipidemia and the severity of coronary heart disease in Chinese women.
HBV inhibits ApoA5 expression at both the transcriptional and translational levels through its core gene
Compared with APOA5 c.553 GG carriers, c.553T carriers displayed an increased risk of HTG in the Asian population, with an overall random effects OR of 3.55 (95% CI: 2.46-5.13) in the dominant model.Our results suggest that APOA5 c. 553T is an independent risk factor for HTG and increased triglyceride levels in the Asian population.
novel role for ApoA5 as a modulator of susceptibility to diet-induced liver and muscle insulin (show INS Proteins) resistance through regulation of ectopic lipid accumulation in liver and skeletal muscle.
The data suggest that apoA-V suppresses the production of chylomicrons, playing a previously unknown role in lipid metabolism that may contribute to the postprandial hypertriglyceridemia associated with apoA-V deficiency.
Data indicate that apolipoprotein A5 (APOA5) plays a role in the central regulation of food intake.
Clearance of triglyceride-rich lipoproteins by hepatic SDC1 (show SDC1 Proteins) is atheroprotective and mediated by multivalent binding to ApoE (show APOE Proteins) and ApoAV.
Gene transfer of human apoA-V improves the severe hypertriglyceridemia phenotype of apoa5 null mice.
Intravenously injected apoA-V rHDL significantly lowers plasma TG in an apoA-V deficient mouse model and requires gpihbp1 (show GPIHBP1 Proteins).
Data show that livers from apolipoprotein A-V (APOA-V) transgenic mice contain significantly higher amounts of triglycerides than livers from wild-type or apoA-V knockout mice, suggesting that apoA-V influences intrahepatic triglyceride levels.
Preferential association of apoA-V(1-146) with murine plasma HDL (show HSD11B1 Proteins), but not with VLDL, suggests that particle size is a determinant of its lipoprotein binding specificity.
a role of ApoA-V in regulating levels of circulating triglycerides and cholesterol.
Review. APOA5 represents a newly discovered gene involved in triglyceride metabolism in both humans and mice whose mechanism of action remains to be deciphered.
gene polymorphisms in APOA5 and APOC3 (show APOC3 Proteins) are associated with meat quality traits in Kele pigs
The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified.
, apolipoprotein AV
, apolipoprotein A5
, regeneration-associated protein 3