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Human APOA5 Protein expressed in Wheat germ - ABIN1345336
Guardiola, Alvaro, Vallvé, Rosales, Solà, Girona, Serra, Duran, Esteve, Masana, Ribalta: APOA5 gene expression in the human intestinal tissue and its response to in vitro exposure to fatty acid and fibrate. in Nutrition, metabolism, and cardiovascular diseases : NMCD 2012
ur data indicate that the APOA5 rs662799 polymorphism is associated with dyslipidemia and the severity of coronary heart disease in Chinese women.
HBV inhibits ApoA5 expression at both the transcriptional and translational levels through its core gene
Compared with APOA5 c.553 GG carriers, c.553T carriers displayed an increased risk of HTG in the Asian population, with an overall random effects OR of 3.55 (95% CI: 2.46-5.13) in the dominant model.Our results suggest that APOA5 c. 553T is an independent risk factor for HTG and increased triglyceride levels in the Asian population.
Genetic polymorphisms of T-1131C APOA5 and ALOX5AP (show ALOX5AP Proteins) SG13S114 can be considered risk factors for the susceptibility to ischemic stroke in Morocco.
Data show that polymorphisms of rs662799 and rs2266788 in APOA5 gene, rs320 in LPL (show LCP1 Proteins) gene and rs708272 in CETP (show CETP Proteins) gene had significant association with the effect of the lipid-lowering therapy via atorvastatin on ischemic stroke patients.
In this study, we investigated the association between the ApoA5 -1131T>C and -12,238T>C polymorphic loci in Korean patients with metabolic syndrome
Serum triglycerides and very low-density protein levels were significantly high in children and adolescents carrying the 19WW apoa5 genotype.
meta-analysis provides substantial evidence that the APOA5 -1131T/C polymorphism might contribute to coronary artery disease development in the Chinese population
When the inter-dependence between alleles was examined using conditional models, five loci on BUD13, ZNF259 (show znf259 Proteins), and ApoA5 showed possible independent associations.
The results of our meta-analysis point to a strong link between both APOA5 -1131T>C and APOC3 (show APOC3 Proteins) -455T>C polymorphisms and an increased risk ofcoronary heart disease .
novel role for ApoA5 as a modulator of susceptibility to diet-induced liver and muscle insulin (show INS Proteins) resistance through regulation of ectopic lipid accumulation in liver and skeletal muscle.
The data suggest that apoA-V suppresses the production of chylomicrons, playing a previously unknown role in lipid metabolism that may contribute to the postprandial hypertriglyceridemia associated with apoA-V deficiency.
Data indicate that apolipoprotein A5 (APOA5) plays a role in the central regulation of food intake.
Clearance of triglyceride-rich lipoproteins by hepatic SDC1 (show SDC1 Proteins) is atheroprotective and mediated by multivalent binding to ApoE (show APOE Proteins) and ApoAV.
Gene transfer of human apoA-V improves the severe hypertriglyceridemia phenotype of apoa5 null mice.
Intravenously injected apoA-V rHDL significantly lowers plasma TG in an apoA-V deficient mouse model and requires gpihbp1 (show GPIHBP1 Proteins).
Data show that livers from apolipoprotein A-V (APOA-V) transgenic mice contain significantly higher amounts of triglycerides than livers from wild-type or apoA-V knockout mice, suggesting that apoA-V influences intrahepatic triglyceride levels.
Preferential association of apoA-V(1-146) with murine plasma HDL (show HSD11B1 Proteins), but not with VLDL, suggests that particle size is a determinant of its lipoprotein binding specificity.
a role of ApoA-V in regulating levels of circulating triglycerides and cholesterol.
Review. APOA5 represents a newly discovered gene involved in triglyceride metabolism in both humans and mice whose mechanism of action remains to be deciphered.
gene polymorphisms in APOA5 and APOC3 (show APOC3 Proteins) are associated with meat quality traits in Kele pigs
The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified.
, apolipoprotein AV
, apolipoprotein A5
, regeneration-associated protein 3