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the second half of the photolyase homology region (PHR) of CRY (show CRY2 ELISA Kits) is important for repression through facilitating interaction with BMAL1
found that overexpression of both Clock and Bmal1 suppressed cell growth
our results identified Bmal1 as a novel tumor suppressor gene that elevates the sensitivity of cancer cells to paclitaxel, with potential implications as a chronotherapy timing biomarker in tongue squamous cell carcinoma
The level of BMAL1 expression in granulosa cells the polycystic ovary syndrome (PCOS) group was lower than that of the group without PCOS. We also analyzed estrogen synthesis and aromatase (show CYP19A1 ELISA Kits) expression in KGN cell lines. Both were downregulated after BMAL1 and SIRT1 (show SIRT1 ELISA Kits) knock-down and, conversely, upregulated after overexpression treatments of these two genes in KGN cells.
this study shows that BMAL1 can regulate cellular innate immunity against specific RNA viruses
Bmal1 is a key clock gene to involve in cartilage homeostasis mediated through sirt1 (show SIRT1 ELISA Kits).
The BMAL1 rs2278749 T/C was associated with Alzheimer disease (AD) risk, and T carriers in BMAL1 rs2278749 T/C showed a higher risk of AD than did non-carriers.
Our results indicate that activation of TGF-beta1 (show TGFB1 ELISA Kits) promotes the transcriptional induction of BMAL1.
possible circadian rhythm in full-term placental expression
Synchronized cells exhibit an autonomous ultradian mitochondrial respiratory activity which is abrogated by silencing the master clock gene BMAL1.
decreased expression of Bmal1 is correlated with tumor progression and poor prognosis in pancreatic ductal adenocarcinoma, with potential to be used as a biomarker for diagnosis and prognosis
The circadian clock component Bmal1 is involved in blood brain barrier homeostasis.
Study shows a role for Bmal1, the endogenous circadian clock, in glucose metabolism in the skeletal muscle. Findings implicate altered molecular clock dictating significant changes in altered substrate metabolism in the absence of feeding or activity changes.
A significant proportion of circadian lncRNAs are expressed at enhancer regions, mostly bound by two key circadian transcription factors, BMAL1 and REV-ERBalpha (show NR1D1 ELISA Kits).
A cis (show CISH ELISA Kits)/trans isomerization switch in the BMAL1 transactivation domain controls circadian rhythms. Conformationally locking the switch or inhibiting prolyl isomerases influences circadian period to suggest that slow protein dynamics play a role in timekeeping.
Bmal1 deficiency in macrophages promotes atherosclerosis by enhancing recruitment of Ly6chi monocytes to atherosclerotic lesions.
Bmal1 autophagic degradation and Bmal1 role in glucose homeostasis
These results suggest that miR (show MLXIP ELISA Kits)-27b-3p plays an important role in the posttranscriptional regulation of BMAL1 protein in the liver.
Bmal1 is a potent negative regulator in myeloid cells in the context of allergic asthma.
Data demonstrate that CLOCK and BMAL1 regulate muscle insulin (show INS ELISA Kits) sensitivity via SIRT1 (show SIRT1 ELISA Kits), and activation of SIRT1 (show SIRT1 ELISA Kits) might be a potential valuable strategy to attenuate muscle insulin (show INS ELISA Kits) resistance related to circadian misalignment.
Results indicated that pBMAL1 cDNA had a coding region of 1,878 bp and shared 94.36, 89.85 and 89.79% identity with human, mouse and rat BMAL1. pBMAL1 expression levels in different tissues were studied.
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene.
aryl hydrocarbon receptor nuclear translocator-like protein 1
, brain and muscle Arnt-like protein 1
, aryl hydrocarbon receptor nuclear translocator-like
, Brain and muscle ARNT-like 1
, brain and muscle ARNT-like 1
, aryl hydrocarbon receptor nuclear translocator-like protein 1-like
, aryl hydrocarbon receptor nuclear translocater
, ARNT-like protein 1, brain and muscle
, PAS domain-containing protein 3
, bHLH-PAS protein JAP3
, basic-helix-loop-helix-PAS orphan MOP3
, basic-helix-loop-helix-PAS protein MOP3
, class E basic helix-loop-helix protein 5
, member of PAS protein 3
, member of PAS superfamily 3
, bHLH-PAS transcription factor BMAL1
, clock protein
, brain and muscle ARNT-like protein 1