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High CDK19 expression is associated with osteosarcoma.
On stimulation of TLR9 (show TLR9 ELISA Kits), CDK8 (show CDK8 ELISA Kits)/19 positively regulates inflammatory gene transcription in cooperation with NF-kappaB (show NFKB1 ELISA Kits) and C/EBPbeta (show CEBPB ELISA Kits).
Data suggest that, during neurogenesis, Mediator complex cyclin (show PCNA PLURAL_@22317@)-dependent kinases (CDK8 (show CDK8 PLURAL_@22317@), CDK19) interact directly with PRC2 (polycomb (show CBX2 PLURAL_@22317@) repressive complex 2) subunit EZH2 (enhancer of zeste homolog 2 (show EZH2 PLURAL_@22317@)), as well as SUZ12 (suppressor of zeste 12 homolog (show SUZ12 PLURAL_@22317@)).
Mediator-associated kinases CDK8 (show CDK8 ELISA Kits) and CDK19 restrain increased activation of key super-enhancer-associated genes in acute myeloid leukaemia (AML (show RUNX1 ELISA Kits)) cells
Microarrays identified target genes for each CDK (show CDK4 ELISA Kits), and we selected six genes: two target genes of CDK8 (show CDK8 ELISA Kits), two target genes of CDK19 and two genes that were targets for both.
CDK8 (show CDK8 ELISA Kits) and CDK19, individually interact with PRMT5 (show PRMT5 ELISA Kits) and WDR77 (show WDR77 ELISA Kits), and their interactions with PRMT5 (show PRMT5 ELISA Kits) cause transcriptional repression of C/EBPbeta (show CEBPB ELISA Kits) target genes.
This gene encodes a protein that is one of the components of the Mediator coactivator complex. The Mediator complex is a multiprotein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex.
CDC2-related protein kinase 6
, CDK8-like cyclin-dependent kinase
, cell division cycle 2-like 6 (CDK8-like)
, cell division cycle 2-like protein kinase 6
, cell division protein kinase 19
, cyclin dependent kinase 19 variant 2
, cyclin-dependent kinase (CDC2-like) 11
, cyclin-dependent kinase 11
, death-preventing kinase
, cyclin-dependent kinase 8