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Browse our anti-CLOCK (CLOCK) Antibodies

Full name:
anti-Clock Homolog (Mouse) Antibodies (CLOCK)
On www.antibodies-online.com are 115 Clock Homolog (Mouse) (CLOCK) Antibodies from 22 different suppliers available. Additionally we are shipping CLOCK Kits (7) and CLOCK Proteins (5) and many more products for this protein. A total of 135 CLOCK products are currently listed.
Synonyms:
5330400M04Rik, bHLHe8, bHLHe10, CG7391, clk, clock, dClck, dclk, dCLK/JRK, dClock, Dmel\\CG7391, Jerk, jrk, KAT13D, mKIAA0334, PAS1, Xclk, XClock, zCLOCK1, zfCLOCK1
list all antibodies Gene Name GeneID UniProt
CLOCK 12753 O08785
CLOCK 60447 Q9WVS9
CLOCK 9575 O15516

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Most Popular Reactivities for anti-CLOCK (CLOCK) Antibodies

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anti-Mouse (Murine) CLOCK Antibodies:

anti-Rat (Rattus) CLOCK Antibodies:

anti-Human CLOCK Antibodies:

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Top referenced anti-CLOCK Antibodies

  1. Human Polyclonal CLOCK Primary Antibody for ChIP, WB - ABIN151057 : Jin, Shearman, Weaver, Zylka, de Vries, Reppert: A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. in Cell 1999 (PubMed)
    Show all 6 references for ABIN151057

  2. Human Polyclonal CLOCK Primary Antibody for EIA, IHC (p) - ABIN359753 : Marino, Holt, Chen, Davis: Shift work, hCLOCK T3111C polymorphism, and endometriosis risk. in Epidemiology (Cambridge, Mass.) 2008 (PubMed)
    Show all 3 references for ABIN359753

  3. Human Monoclonal CLOCK Primary Antibody for ICC, ELISA - ABIN969059 : Lee, Paik, Kang, Lim, Kim: Allelic variants interaction of CLOCK gene and G-protein beta3 subunit gene with diurnal preference. in Chronobiology international 2007 (PubMed)
    Show all 2 references for ABIN969059

  4. Human Polyclonal CLOCK Primary Antibody for ELISA, WB - ABIN564129 : Kalamvoki, Roizman: Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expression. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

  5. Human Polyclonal CLOCK Primary Antibody for IHC, ELISA - ABIN1533501 : Steeves, King, Zhao, Sangoram, Du, Bowcock, Moore, Takahashi: Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei. in Genomics 1999 (PubMed)

More Antibodies against CLOCK Interaction Partners

Fruit Fly (Drosophila melanogaster) Clock Homolog (Mouse) (CLOCK) interaction partners

  1. Here we demonstrate that the transcription factor CLOCKWORK ORANGE (CWO) antagonizes CLK-CYC (show COX6C Antibodies) E-box binding, thus enhancing the removal of CLK-CYC (show COX6C Antibodies) from E-boxes to maintain transcriptional repression. This process requires PER, which suggests that PER-TIM and CWO cooperate to maintain a transcriptionally repressed state by removing CLK-CYC (show COX6C Antibodies) from E-boxes

  2. these results demonstrate a key role of Clk post-transcriptional control in stabilizing circadian transcription.

  3. Our findings suggest a novel role for clock protein (show ARNTL Antibodies) phosphorylation in governing the relative strengths of entraining modalities by adjusting the dynamics of circadian gene expression.

  4. These results demonstrate that CLK phosphorylation influences the circadian period by regulating CLK activity and progression through the feedback loop.

  5. Computational dissection of CLK/CYC (show COX6C Antibodies) context-specific binding sites reveals sequence motifs for putative partner factors, which are predictive for individual binding sites

  6. usp8 (show USP8 Antibodies) loss of function (RNAi) or expression of a dominant-negative form of the protein (USP8 (show USP8 Antibodies)-DN) enhances CLK/CYC (show COX6C Antibodies) transcriptional activity and alters fly locomotor activity rhythms

  7. CLK has specific targets in different tissues, implying that important CLK partner proteins and/or mechanisms contribute to gene-specific and tissue-specific regulation

  8. CTRIP destabilizes CLK protein in a PER-independent manner and helps degradation of phosphorylated PER and TIM in the morning

  9. dPER(DeltaCBD) does not provoke the daily hyperphosphorylation of dCLOCK, indicating that direct interactions between dPER and dCLOCK are necessary for the dCLOCK phosphorylation

  10. findings show that Clk and cyc (show COX6C Antibodies) act during starvation to modulate the conflict of whether flies sleep or search for food

Zebrafish Clock Homolog (Mouse) (CLOCK) interaction partners

  1. effect of CRY (show CRY2 Antibodies) in repressing transcription mediated by CLOCK-BMAL heterodimer

Mouse (Murine) Clock Homolog (Mouse) (CLOCK) interaction partners

  1. Abundance of CDH1 (show CDH1 Antibodies) and TP63 (show TP63 Antibodies) proteins were significantly reduced in cultures transfected with shClock These data support how CLOCK plays a role in regulation of epithelial cell growth and differentiation in the mammary gland.

  2. Data demonstrate that CLOCK and BMAL1 (show ARNTL Antibodies) regulate muscle insulin (show INS Antibodies) sensitivity via SIRT1 (show SIRT1 Antibodies), and activation of SIRT1 (show SIRT1 Antibodies) might be a potential valuable strategy to attenuate muscle insulin (show INS Antibodies) resistance related to circadian misalignment.

  3. These data establish the importance of circadian CLOCK-inhibin signaling in sepsis.

  4. our results indicate that Clock is a key regulator of AKT (show AKT1 Antibodies) signalling for triggering cardiac hypertrophy in vivo.

  5. Report altered BMAL1 (show ARNTL Antibodies)/CLOCK expression in conditions of chronically altered blood flow.

  6. PI3K signaling plays a modulatory role in the regulation of the transcriptional rhythm of the Dbp (show GC Antibodies) gene by targeting BMAL1 (show ARNTL Antibodies) and CLOCK.

  7. Both clock- and feeding-dependent mechanisms regulate the daily accumulation of key enzymes in polyamine biosynthesis through rhythmic binding of BMAL1 (show ARNTL Antibodies):CLOCK to conserved DNA elements

  8. RNA interference screens reveal the heterodimeric, circadian rhythm Transcription factors Clock and Bmal1 (show ARNTL Antibodies) as genes required for the growth of acute myeloid leukemia (show BCL11A Antibodies) cells in vitro and in vivo.

  9. Findings indicate that CLOCK protein (show ARNTL Antibodies) plays an important role in fertility and its knockdown leads to reduction in reproduction and increased miscarriage risk.

  10. Irp2 (show IREB2 Antibodies) mRNA transcription is promoted by circadian clock genes, including BMAL1 (show ARNTL Antibodies), and the CLOCK heterodimer.

Human Clock Homolog (Mouse) (CLOCK) interaction partners

  1. Clock circadian regulator (CLOCK) gene single nucleotide polymorphism rs1801260 minor allele C showed a significantly higher association with the prevalence of diabetes in the Japanese population independent of body mass index (BMI).

  2. Immunostaining of CLOCK and PER2 (show PER2 Antibodies) protein was detected in the granulosa cells of dominant antral follicles but was absent in the primordial, primary, or preantral follicles of human ovaries.Oscillating expression of the circadian gene PER2 (show PER2 Antibodies) can be induced by testosterone in human granulosa cells in vitro. Expression of STAR also displayed an oscillating pattern after testosterone stimulation

  3. possible circadian rhythm in full-term placental expression

  4. Findings indicate that CLOCK protein (show ARNTL Antibodies) plays an important role in fertility and its knockdown leads to reduction in reproduction and increased miscarriage risk.

  5. Upregulation of CLOCK is associated with the expression of HIF-1alpha and VEGF in varicose veins.

  6. when overexpressed, c-MYC (show MYC Antibodies) is able to repress Per1 (show PER1 Antibodies) transactivation by BMAL1 (show ARNTL Antibodies)/CLOCK via targeting selective E-box sequences. Importantly, upon serum stimulation, MYC (show MYC Antibodies) was detected in BMAL1 (show ARNTL Antibodies) protein complexes

  7. CLOCK, ARNTL (show ARNTL Antibodies), and NPAS2 (show NPAS2 Antibodies) gene polymorphisms may have a role in seasonal variations in mood and behavior

  8. minor polymorphisms of CLOCK may be associated with poor morning gastric motility, and may have a combinatorial effect with PER3.

  9. these findings suggest that sumoylation plays a critical role in the spatiotemporal co-activation of CLOCK-BMAL1 (show ARNTL Antibodies) by CBP (show CREBBP Antibodies) for immediate-early (show JUN Antibodies) Per induction and the resetting of the circadian clock.

  10. the circadian gene hClock promoted CRC (show CALR Antibodies) progression and inhibit tumor cell apoptosis in vitro and in vivo, while silencing hClock was able to reverse this effect.

Xenopus laevis Clock Homolog (Mouse) (CLOCK) interaction partners

  1. the second half of the photolyase homology region (PHR) of CRY (show CRY2 Antibodies) is important for repression through facilitating interaction with CLOCK

CLOCK Antigen Profile

Antigen Summary

This gene product regulates circadian rhythm and metabolism. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and a DNA binding histone acetyltransferase. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with CLOCK

  • Clock (Clk) antibody
  • clock homolog (mouse) (CLOCK) antibody
  • clock circadian regulator (clock) antibody
  • clock homolog (CLOCK) antibody
  • clock (clock) antibody
  • circadian locomotor output cycles kaput (Clock) antibody
  • clock circadian regulator (Clock) antibody
  • clock circadian regulator (CLOCK) antibody
  • 5330400M04Rik antibody
  • bHLHe8 antibody
  • bHLHe10 antibody
  • CG7391 antibody
  • clk antibody
  • clock antibody
  • dClck antibody
  • dclk antibody
  • dCLK/JRK antibody
  • dClock antibody
  • Dmel\\CG7391 antibody
  • Jerk antibody
  • jrk antibody
  • KAT13D antibody
  • mKIAA0334 antibody
  • PAS1 antibody
  • Xclk antibody
  • XClock antibody
  • zCLOCK1 antibody
  • zfCLOCK1 antibody

Protein level used designations for CLOCK

CG7391-PA , CG7391-PD , CG7391-PF , CG7391-PG , CG7391-PH , CLOCK , Clk-PA , Clk-PD , Clk-PF , Clk-PG , Clk-PH , clock , dClock , clock homolog (mouse) , clock homolog , circadian locomoter output cycles protein kaput , circadian locomoter output cycles protein kaput-like , Clock1a , clk1 , circadian locomoter output cycles kaput , mCLOCK , rCLOCK , circadian locomoter output cycles kaput protein , class E basic helix-loop-helix protein 8 , circadian rhythmicity protein CLOCK

GENE ID SPECIES
38872 Drosophila melanogaster
461312 Pan troglodytes
475145 Canis lupus familiaris
786637 Bos taurus
100008576 Meleagris gallopavo
100017022 Monodelphis domestica
100034166 Equus caballus
100038163 Xenopus (Silurana) tropicalis
100171391 Ovis aries
100172630 Pongo abelii
100349684 Oryctolagus cuniculus
100407407 Callithrix jacchus
30140 Danio rerio
100606130 Nomascus leucogenys
100628097 Sus scrofa
12753 Mus musculus
60447 Rattus norvegicus
9575 Homo sapiens
399157 Xenopus laevis
373991 Gallus gallus
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