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anti-Mouse (Murine) CTGF Antibodies:
anti-Human CTGF Antibodies:
anti-Rat (Rattus) CTGF Antibodies:
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Human Polyclonal CTGF Primary Antibody for IHC (p), WB - ABIN3042771
Li, Zhang, Wang, Zheng, Chen: Nicousamide blocks the effects of advanced glycation end products on renal cells. in European journal of pharmacology 2012
Show all 8 Pubmed References
Human Polyclonal CTGF Primary Antibody for ICC, IF - ABIN152147
Alfaro, Deskins, Wallus, DasGupta, Davidson, Nanney, A Guney, Gannon, Young: A physiological role for connective tissue growth factor in early wound healing. in Laboratory investigation; a journal of technical methods and pathology 2012
Show all 4 Pubmed References
Human Polyclonal CTGF Primary Antibody for IF (p), IHC (p) - ABIN672636
Tian, Lv, Yang, Zhang, Yu, Zhu, Xiao, Zhu: Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats. in International journal of clinical and experimental pathology 2014
Show all 3 Pubmed References
Human Polyclonal CTGF Primary Antibody for Func, IF - ABIN2473119
Sánchez de la Muela, Zudaire, Robles, Rosell, Aguera, De Castro, Isa, Berián: [Survival analysis in renal cell carcinoma with invasion of the vena cava]. in Actas urologicas españolas 1991
Show all 3 Pubmed References
Human Polyclonal CTGF Primary Antibody for ELISA, WB - ABIN2473120
Moussad, Brigstock: Connective tissue growth factor: what's in a name? in Molecular genetics and metabolism 2000
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Human Monoclonal CTGF Primary Antibody for ELISA, WB - ABIN514745
Polacek, Bruun, Johansen, Martinez: Comparative Analyses of the Secretome from Dedifferentiated and Redifferentiated Adult Articular Chondrocytes. in Cartilage 2015
Human Polyclonal CTGF Primary Antibody for IHC, IHC (p) - ABIN4300783
Livingston, Ding, Huang, Hill, Yin, Dong: Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction. in Autophagy 2016
Human Polyclonal CTGF Primary Antibody for WB - ABIN223605
Chen, Lan, Zhou, Li, Zhang, Zhang, Yang, Li: Astilbin attenuates hyperuricemia and ameliorates nephropathy in fructose-induced hyperuricemic rats. in Planta medica 2011
These data suggest that CTGF levels are increased in multiple organs after radiation exposure and that inflammatory cell infiltration may contribute to the elevated levels of CTGF in multiple organs.
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
this study reveals that CTGF is necessary and sufficient to stimulate glial bridging and natural spinal cord regeneration.
CTGF/CCN2 plays an important role in notochord development and is required for general embryonic development
LPA-LPA1 (show LPAR1 Antibodies) signaling initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor.
Down-regulation of CTGF is effective in inhibiting postoperative scarring in vivo. This suggests that RNAi with CTGF siRNA may potentially pave the road for a novel therapeutic strategy to improve glaucoma surgery results.
CTGF role in cardiac fibrosis. Long noncoding RNA H19 (show NCKAP1 Antibodies) mediates CTGF expression.
Notch1 (show NOTCH1 Antibodies) haploinsufficiency decreased the expression of Ctgf in the aorta and in vitro cell culture system. In vitro studies on SMCs using the Notch1 (show NOTCH1 Antibodies) intracellular domain (NICD (show NOTCH1 Antibodies)) plasmid, dominant negative mastermind-like (dnMAML), or specific siRNA suggest that Notch1 (show NOTCH1 Antibodies), not Notch3 (show NOTCH3 Antibodies), directly modulates the expression of CTGF
these findings show that cardiac ERK1/2 (show MAPK1/3 Antibodies) activity is modulated in part by TGF-b/Smad (show SMAD1 Antibodies) signaling, leading to altered activation of CTGF/CCN2 to mediate fibrosis and alter cardiac function. This identifies a novel mechanism in the development of LMNA (show LMNA Antibodies) cardiomyopathy.
the mechanistic target of rapamycin (mTOR (show FRAP1 Antibodies)) pathway in neurons regulates CTGF production and secretion, revealing a paracrine mechanism by which neuronal signaling regulates oligodendrocyte maturation and myelination in tuberous sclerosis complex (TSC (show SLC12A3 Antibodies)).
CCN2 suppression by miR (show MLXIP Antibodies)-199a-5p accounts, in part, for low-level fibrogenic gene expression in quiescent hepatic stellate cells (HSCs) and causes dampened gene expression in activated HSCs after horizontal transfer of miR (show MLXIP Antibodies)-199a-5p in exosomes from quiescent HSCs.
In summary, our data suggest that in obstructive nephropathy atrophy increases and fibrosis decreases with age and that this relates to increased BMP signaling, most likely due to higher BMP6 (show BMP6 Antibodies) and lower CTGF expression.
Overexpression of CTGF in cardiomyocytes attenuates left ventricular hypertrophy in angiotensin II induced hypertension.
beta-catenin (show CTNNB1 Antibodies) signaling inhibition protects against CTGF-induced alveolar and vascular pathology in neonatal mouse lung
Results demonstrat that GDF8 (show MSTN Antibodies) stimulates the expression and secretion of CTGF in human granulosa cells and provide evidence that both proteins may play critical roles in the regulation of extracellular matrix formation in these cells.
combined inhibition of ALK5 (show TGFBR1 Antibodies) and CTGF is required to prevent TGFbeta (show TGFB1 Antibodies)-induced nodule formation in tri (show VANGL2 Antibodies)-cellular cultures
YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) and Smad2 (show SMAD2 Antibodies) regulate CTGF expression in tubular epithelial cells. Reduced nuclear Smad2 (show SMAD2 Antibodies) correlated with impaired CTGF secretion in DMOG-treated cells and transient downregulation of Smad2 (show SMAD2 Antibodies) interfered with TGFbeta (show TGFB1 Antibodies)-1-induced CTGF synthesis. YAP (show YAP1 Antibodies) is an indispensable transcription factor involved in CTGF synthesis.
CTGF mediates TGF-beta1 (show TGFB1 Antibodies)-inhibited human trophoblast cell invasion.
RPTOR (regulatory associated protein of mTOR (show RPTOR Antibodies), complex 1) is a novel target of miR (show MLXIP Antibodies)-155 in CF lung epithelial cells. The suppression of RPTOR (show RPTOR Antibodies) expression and subsequent activation of TGF-beta (show TGFB1 Antibodies) signaling resulted in the induction of fibrosis by elevating connective tissue growth factor (CTGF) abundance in CF lung epithelial cells.
The present findings indicate that genetic variation in CTGF may contribute to the attainment of extreme old age in Japanese.
SC-derived CCN2 partially accelerated tumor growth in vitro.
We document for the first time a functional role of CTGF in altering disease progression in a lymphoid malignancy. The findings provide support for targeting the bone marrow microenvironment in aggressive forms of leukaemia.
Data suggest that CTGF could be involved in oncogenic pathways promoting non-viral hepatocellular carcinoma associated with metabolic risk factors via induction of liver inflammation.
CCN2 was transiently expressed at the leading keratinocyte edge in wound healing.
Atrial fibrillation patients and animals exhibited a significantly increased expression of connective tissue growth factor (CTGF). Angiotension II-induced CTGF expression might be involved in atrial substrate remodeling.
CTGF in trabecular meshwork is modulated by physiological agonists and by increased ocular pressure and mechanical stretch. Regulation of CTGF within outflow pathway may play role in homeostasis of intraocular pressure.
CTGF level was not altered in model of obliterative bronchiolitis.
The results indicate that CTGF suppresses the synthesis of biglycan (show BGN Antibodies) but newly induced that of decorin (show DCN Antibodies) in the cells when the cell density is low.
Actin cytoskeleton-dependent regulation of CTGF transcription and mRNA stability
A significant increase in TGF-beta1 (show TGFB1 Antibodies) and CTGF was found at 6 weeks in the subsynovial connective tissue in a rabbit model of carpal tunnel syndrome.
Stretch is an important primary trigger for CTGF-induction in the overloaded heart.
Connective tissue growth factor is expressed in the naive cornea, lens, iris, and retina, and is expressed immediately after epithelial injury. Loss of CTGF impairs efficient re-epithelialization of corneal wounds.
TGF-beta1 (show TGFB1 Antibodies) can inhibit the growth of urethra epithelium cells and induce the expression of CTGF.
Overexpression of CTGF in the blebs after trabeculectomy demonstrates that CTGF may play an important role in the process of wound healing.
Recombinant CTGF added to embryonic mouse neural precursor cell culture increased the number of Sox-2 (show SOX2 Antibodies)-, GFAP (show GFAP Antibodies)-and GFAP (show GFAP Antibodies)/Nestin (show NES Antibodies)-positive cells, activated p44 (show GTF2H2 Antibodies)/42 signaling, and upregulated fibronectin (show FN1 Antibodies). In human glioma cells, it induced GFAP (show GFAP Antibodies) and nestin (show NES Antibodies).
Data show that connective-tissue growth factor regulates signalling through the Wnt (show WNT2 Antibodies) pathway, in accord with its ability to bind to the Wnt (show WNT2 Antibodies) co-receptor LDL receptor (show LDLR Antibodies)-related protein 6 (LRP6 (show LRP6 Antibodies)).
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
WNT1 inducible signaling pathway protein 2
, connective tissue growth factor
, Connective tissue growth factor
, connective tissue growth factor-like
, CCN family member 2
, Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24)
, fibroblast inducible secreated protein
, fibroblast inducible secreted protein
, hypertrophic chondrocyte-specific gene product 24
, hypertrophic chondrocyte-specific protein 24
, IGF-binding protein 8
, insulin-like growth factor-binding protein 8
, connective tissue growth-related protein
, connective tissue growth factor XCTGF