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Human CTGF ELISA Kit for Sandwich ELISA - ABIN415039
Shi, Chang, Yang, Zhang, Yu, Wu: Activation of JNK signaling mediates connective tissue growth factor expression and scar formation in corneal wound healing. in PLoS ONE 2012
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Rat (Rattus) CTGF ELISA Kit for Sandwich ELISA - ABIN416372
Abramovich, Irusta, Bas, Cataldi, Parborell, Tesone: Angiopoietins/TIE2 system and VEGF are involved in ovarian function in a DHEA rat model of polycystic ovary syndrome. in Endocrinology 2012
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Mouse (Murine) CTGF ELISA Kit for Sandwich ELISA - ABIN415622
Murakami, Kohno, Kadoya, Nagahara, Fujii, Seno, Yamamoto, Oda, Fujiwara, Kubo, Morita, Nakada, Hla, Kawahito: Knock out of S1P3 receptor signaling attenuates inflammation and fibrosis in bleomycin-induced lung injury mice model. in PLoS ONE 2014
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Human CTGF ELISA Kit for Sandwich ELISA - ABIN365076
Kurita, Okazaki, Kaminishi-Tanikawa, Niikura, Takushima, Harii: Differential expression of wound fibrotic factors between facial and trunk dermal fibroblasts. in Connective tissue research 2012
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Mouse (Murine) CTGF ELISA Kit for Sandwich ELISA - ABIN454828
Zhang, Chang, Chen, Zhang, Luo, Hamblin, Villacorta, Xiong, Chen, Zhang, Zhu: Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor. in Cardiovascular research 2011
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Pig (Porcine) CTGF ELISA Kit for Sandwich ELISA - ABIN415942
Shimazaki, Karakida, Yamamoto, Kobayashi, Fukae, Yamakoshi, Asada: TGF-β and Physiological Root Resorption of Deciduous Teeth. in International journal of molecular sciences 2016
Rat (Rattus) CTGF ELISA Kit for Sandwich ELISA - ABIN368064
Jiang, Yamashita, Chew, Akatsuka, Ukai, Wang, Nagai, Okazaki, Takahashi, Toyokuni: Connective tissue growth factor and ?-catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma. in The Journal of pathology 2014
These data suggest that CTGF levels are increased in multiple organs after radiation exposure and that inflammatory cell infiltration may contribute to the elevated levels of CTGF in multiple organs.
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
this study reveals that CTGF is necessary and sufficient to stimulate glial bridging and natural spinal cord regeneration.
CTGF/CCN2 plays an important role in notochord development and is required for general embryonic development
LPA-LPA1 (show LPAR1 ELISA Kits) signaling initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor.
Down-regulation of CTGF is effective in inhibiting postoperative scarring in vivo. This suggests that RNAi with CTGF siRNA may potentially pave the road for a novel therapeutic strategy to improve glaucoma surgery results.
CTGF role in cardiac fibrosis. Long noncoding RNA H19 (show NCKAP1 ELISA Kits) mediates CTGF expression.
Notch1 (show NOTCH1 ELISA Kits) haploinsufficiency decreased the expression of Ctgf in the aorta and in vitro cell culture system. In vitro studies on SMCs using the Notch1 (show NOTCH1 ELISA Kits) intracellular domain (NICD (show NOTCH1 ELISA Kits)) plasmid, dominant negative mastermind-like (dnMAML), or specific siRNA suggest that Notch1 (show NOTCH1 ELISA Kits), not Notch3 (show NOTCH3 ELISA Kits), directly modulates the expression of CTGF
these findings show that cardiac ERK1/2 (show MAPK1/3 ELISA Kits) activity is modulated in part by TGF-b/Smad (show SMAD1 ELISA Kits) signaling, leading to altered activation of CTGF/CCN2 to mediate fibrosis and alter cardiac function. This identifies a novel mechanism in the development of LMNA (show LMNA ELISA Kits) cardiomyopathy.
the mechanistic target of rapamycin (mTOR (show FRAP1 ELISA Kits)) pathway in neurons regulates CTGF production and secretion, revealing a paracrine mechanism by which neuronal signaling regulates oligodendrocyte maturation and myelination in tuberous sclerosis complex (TSC (show SLC12A3 ELISA Kits)).
CCN2 suppression by miR (show MLXIP ELISA Kits)-199a-5p accounts, in part, for low-level fibrogenic gene expression in quiescent hepatic stellate cells (HSCs) and causes dampened gene expression in activated HSCs after horizontal transfer of miR (show MLXIP ELISA Kits)-199a-5p in exosomes from quiescent HSCs.
In summary, our data suggest that in obstructive nephropathy atrophy increases and fibrosis decreases with age and that this relates to increased BMP signaling, most likely due to higher BMP6 (show BMP6 ELISA Kits) and lower CTGF expression.
Overexpression of CTGF in cardiomyocytes attenuates left ventricular hypertrophy in angiotensin II induced hypertension.
beta-catenin (show CTNNB1 ELISA Kits) signaling inhibition protects against CTGF-induced alveolar and vascular pathology in neonatal mouse lung
Results demonstrat that GDF8 (show MSTN ELISA Kits) stimulates the expression and secretion of CTGF in human granulosa cells and provide evidence that both proteins may play critical roles in the regulation of extracellular matrix formation in these cells.
combined inhibition of ALK5 (show TGFBR1 ELISA Kits) and CTGF is required to prevent TGFbeta (show TGFB1 ELISA Kits)-induced nodule formation in tri (show VANGL2 ELISA Kits)-cellular cultures
YAP (show YAP1 ELISA Kits)/TAZ (show TAZ ELISA Kits) and Smad2 (show SMAD2 ELISA Kits) regulate CTGF expression in tubular epithelial cells. Reduced nuclear Smad2 (show SMAD2 ELISA Kits) correlated with impaired CTGF secretion in DMOG-treated cells and transient downregulation of Smad2 (show SMAD2 ELISA Kits) interfered with TGFbeta (show TGFB1 ELISA Kits)-1-induced CTGF synthesis. YAP (show YAP1 ELISA Kits) is an indispensable transcription factor involved in CTGF synthesis.
CTGF mediates TGF-beta1 (show TGFB1 ELISA Kits)-inhibited human trophoblast cell invasion.
RPTOR (regulatory associated protein of mTOR (show RPTOR ELISA Kits), complex 1) is a novel target of miR (show MLXIP ELISA Kits)-155 in CF lung epithelial cells. The suppression of RPTOR (show RPTOR ELISA Kits) expression and subsequent activation of TGF-beta (show TGFB1 ELISA Kits) signaling resulted in the induction of fibrosis by elevating connective tissue growth factor (CTGF) abundance in CF lung epithelial cells.
The present findings indicate that genetic variation in CTGF may contribute to the attainment of extreme old age in Japanese.
SC-derived CCN2 partially accelerated tumor growth in vitro.
We document for the first time a functional role of CTGF in altering disease progression in a lymphoid malignancy. The findings provide support for targeting the bone marrow microenvironment in aggressive forms of leukaemia.
Data suggest that CTGF could be involved in oncogenic pathways promoting non-viral hepatocellular carcinoma associated with metabolic risk factors via induction of liver inflammation.
CCN2 was transiently expressed at the leading keratinocyte edge in wound healing.
Atrial fibrillation patients and animals exhibited a significantly increased expression of connective tissue growth factor (CTGF). Angiotension II-induced CTGF expression might be involved in atrial substrate remodeling.
CTGF in trabecular meshwork is modulated by physiological agonists and by increased ocular pressure and mechanical stretch. Regulation of CTGF within outflow pathway may play role in homeostasis of intraocular pressure.
CTGF level was not altered in model of obliterative bronchiolitis.
The results indicate that CTGF suppresses the synthesis of biglycan (show BGN ELISA Kits) but newly induced that of decorin (show DCN ELISA Kits) in the cells when the cell density is low.
Actin cytoskeleton-dependent regulation of CTGF transcription and mRNA stability
A significant increase in TGF-beta1 (show TGFB1 ELISA Kits) and CTGF was found at 6 weeks in the subsynovial connective tissue in a rabbit model of carpal tunnel syndrome.
Stretch is an important primary trigger for CTGF-induction in the overloaded heart.
Connective tissue growth factor is expressed in the naive cornea, lens, iris, and retina, and is expressed immediately after epithelial injury. Loss of CTGF impairs efficient re-epithelialization of corneal wounds.
TGF-beta1 (show TGFB1 ELISA Kits) can inhibit the growth of urethra epithelium cells and induce the expression of CTGF.
Overexpression of CTGF in the blebs after trabeculectomy demonstrates that CTGF may play an important role in the process of wound healing.
Recombinant CTGF added to embryonic mouse neural precursor cell culture increased the number of Sox-2 (show SOX2 ELISA Kits)-, GFAP (show GFAP ELISA Kits)-and GFAP (show GFAP ELISA Kits)/Nestin (show NES ELISA Kits)-positive cells, activated p44 (show GTF2H2 ELISA Kits)/42 signaling, and upregulated fibronectin (show FN1 ELISA Kits). In human glioma cells, it induced GFAP (show GFAP ELISA Kits) and nestin (show NES ELISA Kits).
Data show that connective-tissue growth factor regulates signalling through the Wnt (show WNT2 ELISA Kits) pathway, in accord with its ability to bind to the Wnt (show WNT2 ELISA Kits) co-receptor LDL receptor (show LDLR ELISA Kits)-related protein 6 (LRP6 (show LRP6 ELISA Kits)).
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
WNT1 inducible signaling pathway protein 2
, connective tissue growth factor
, Connective tissue growth factor
, connective tissue growth factor-like
, CCN family member 2
, Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24)
, fibroblast inducible secreated protein
, fibroblast inducible secreted protein
, hypertrophic chondrocyte-specific gene product 24
, hypertrophic chondrocyte-specific protein 24
, IGF-binding protein 8
, insulin-like growth factor-binding protein 8
, connective tissue growth-related protein
, connective tissue growth factor XCTGF