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Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition.
These results point to a potential 20-HETE dependence of intrarenal angiotensinogen (show AGT ELISA Kits) production and ANGII receptor type 1 activation that are associated with increases in NCC (show SLC12A3 ELISA Kits) and SGK1 (show SGK1 ELISA Kits) and identify elevated P450 (show CYP2B6 ELISA Kits) 4A11 activity and 20-HETE as potential risk factors for salt-sensitive human hypertension by perturbation of the renal renin (show REN ELISA Kits)-angiotensin axis.
CYP4A11 Variants are associated with Ischemic Stroke.
The results suggest that individuals carrying the alleles, K276T and S353G, might exhibit higher catalysis of CYP4A11
CYP4A1l rs9333025 GG and CYP4F2 (show CYP4F2 ELISA Kits) rs2108622 GG two-loci interaction significantly increases the risk for IS and an elevated 20-HETE level.
Single nucleotide polymorphism of CYP4A11 gene is associated with Plaque in Patients with Ischemic Stroke.
Interaction among CYP2C8 (show CYP2C8 ELISA Kits), EPHX2 (show EPHX2 ELISA Kits), and CYP4A11 Gene Variants Significantly Increases the Risk for Ischemic Stroke.
The present study focused on 10 CYP4A11 variant alleles and evaluated their functional characteristics using arachidonic acid as the substrate in a COS-7 cell-based expression system.
To evaluate the associations between four single-nucleotide polymorphisms (SNPs) in CYP4A11 and CYP4F2 (show CYP4F2 ELISA Kits) and ischemic stroke (IS)
The CC genotype and C allele of the CYP4A11 gene were associated with essential hypertension in the male western Chinese Han population.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate.
, P-450 IV4AII
, P-450 K-2
, P450 K-5
, P450-LA-omega 2
, cytochrome P-450 K-2
, cytochrome P450 4A2
, cytochrome P450 K-5
, cytochrome P450, subfamily 4A, polypeptide 11
, cytochrome P450, subfamily IVA, polypeptide 11
, cytochrome P450-LA-omega 2
, lauric acid omega-hydroxylase
, 20-HETE synthase
, 20-hydroxyeicosatetraenoic acid synthase
, alkane-1 monooxygenase
, cytochrome P-450HK-omega
, cytochrome P450 4A11
, cytochrome P450HL-omega
, fatty acid omega-hydroxylase