Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species
Mutation of hmgcs1 had no effect on Shh (show SHH ELISA Kits) signaling at 2 and 3 days post fertilization (dpf), but did result in a decrease in the expression of gli1 (show GLI1 ELISA Kits), a known Shh (show SHH ELISA Kits) target gene, at 4 dpf, after morphological deficits in craniofacial development and chondrocyte differentiation were observed in hmgcs1 mutants.
This study identified a mutation of hmgcs1, coding for Hmg-CoA synthase (show HMGCS2 ELISA Kits) 1, which caused OPCs to migrate past their target axons and interfered with myelin gene expression.
Data suggest that HMGCS1 (HMG-CoA synthase 1) signals through ketogenesis/acetoacetate to promote cell proliferation and BRAF (show BRAF ELISA Kits)(V600E)-dependent MEK1 (show MAP2K1 ELISA Kits) activation in BRAF (show BRAF ELISA Kits)(V600E)-positive melanoma and colon cancer cells; HMGCS1 co-localizes with HMGCL (HMG-CoA lyase (show HMGCL ELISA Kits)) and BRAF (show BRAF ELISA Kits)(V600E) in cytosol of melanoma and colon cancer cells. (BRAF (show BRAF ELISA Kits) = proto-oncogene (show RAB1A ELISA Kits) protein B (show LEPREL2 ELISA Kits)-raf (show SNRPE ELISA Kits))
ACBP (show CPN2 ELISA Kits) is a transcriptional regulator of the HMGCS1 and HMGCR (show HMGCR ELISA Kits) genes encoding rate-limiting enzymes of cholesterol synthesis pathway.
This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
, hydroxymethylglutaryl-CoA synthase, cytoplasmic
, 3-hydroxy-3-methylglutaryl coenzyme A synthase
, hydroxymethylglutaryl coenzyme A synthase
, hydroxymethylglutaryl-CoA synthase 1
, 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
, hydroxymethylglutaryl-CoA synthase, cytoplasmic-like
, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase
, HMG-CoA synthase
, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) isoform 1
, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) isoform 2