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supports a role for Med19 as a PolII holoenzyme-embedded "co-factor" that acts together with Hox (show MSH2 ELISA Kits) proteins through their homeodomains in regulated developmental transcription
LCMR1 modulation was sufficient to positively regulate endogenous Tspan8 (show TSPAN8 ELISA Kits) expression, with concomitant in vitro phenotypic changes such as loss of melanoma cell-matrix adherence and increase in invasion, and Tspan8 (show TSPAN8 ELISA Kits) expression promoted tumourigenicity in vivo.
We knocked down the Med19 expression in prostate cancer cell lines LNCaP and PC3 (show PCSK1 ELISA Kits) by using lentivirus siRNA. Cell proliferation, anchor-independent growth, migration, and invasion were suppressed in Med19 knockdown prostate cancer cells.
Med19 promotes breast cancer cell proliferation and that this effect is associated with regulating CBFA2T3 (show CBFA2T3 ELISA Kits) and HEB (show TCF12 ELISA Kits) expression.
FOXD3 (show FOXD3 ELISA Kits)/miR (show MLXIP ELISA Kits)-214/MED19 axis is important for the regulation of growth, invasion and metastasis of colorectal cancer
High expression of Med19 is associated with cisplatin resistance in non-small cell lung cancer cells.
Data show that the expression of Mediator of RNA polymerase II transcription subunit 19 (Med19) was increased in Osteosarcoma (OS) samples from patients compared to normal bone tissues.
High Med19 expression is associated with tongue cancer.
Med19 promotes bone metastasis and invasiveness of bladder urothelial carcinoma via bone morphogenetic protein 2 (show BMP2 ELISA Kits).
Med19 is markedly up-regulated in bladder cancer tissues
LCMR1 suppresses apoptosis in lung cancer cells and this effect is associated with multiple apoptosis-related proteins, including p53 (show TP53 ELISA Kits), Bax (show BAX ELISA Kits) and Mcl-1 (show MCL1 ELISA Kits).
MED19 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003
mediator complex subunit 19
, mediator of RNA polymerase II transcription, subunit 19 homolog (S. cerevisiae)
, mediator of RNA polymerase II transcription, subunit 19 homolog
, mediator of RNA polymerase II transcription subunit 19
, lung cancer metastasis-related protein 1