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Cellugyrin (show SYNGR2 Proteins) and synaptogyrin have roles in facilitating targeting of synaptophysin (show SYP Proteins) to a ubiquitous synaptic vesicle-sized compartment
SYNGR1 was soluble and stable in a variety of mild detergents and multiple biophysical methods confirmed the folded state of the protein.
The results of association study support a contribution of SYNGR1 to schizophrenia susceptibility.
This research found a novel nonsense mutation (Trp27Ter) in exon 2 of the SYNGR1 gene in a family multiply affected with schizophrenia. And expressed in the brain.
Our results support SYNGR1 as a probable susceptibility gene for schizophrenia and bipolar disorder.
A case-control study with synaptogyrin 1 was conducted in 506 bipolar disorder patients and 507 healthy individuals from the Han Chinese population. No association was found in this study.
This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified.