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A novel function for Ankrd17 in Nod1 (show NOD1 ELISA Kits) and Nod2 (show NOD2 ELISA Kits) mediated anti-bacterial innate immune pathways.
The results indicated that ankrd17 is a positive regulator of the RIG-I (show DDX58 ELISA Kits) signaling pathway. Ankrd17 enhanced the interaction of RIG-I (show DDX58 ELISA Kits) and MDA5 (show IFIH1 ELISA Kits) with VISA (show MAVS ELISA Kits); the ankyrin repeat domain of ankrd17 is required for its interaction with RIG-I (show DDX58 ELISA Kits).
there are overlapping reading frames in the mouse and human genes for 4E-BP3 and MASK
ANKRD17 expression was predominantly restricted to pachytene spermatocytes and round spermatids. ANKRD17 was diffusely distributed throughout the nucleus of pachytene cells but excluded from the XY body and other heterochromatic regions.
Ankrd17 is an important downstream effector of cyclin E (show CCNE1 ELISA Kits)/Cdk2 (show CDK2 ELISA Kits) and positively regulates G(1)/S transition
Data demonstrate the indispensability of Ankrd17 functioning for vascular maturation during early development.
This gene encodes a protein with ankyrin repeats, which are associated with protein-protein interactions. Studies in mice suggest that this protein is involved in liver development. Two transcript variants encoding different isoforms have been found for this gene.
ankyrin repeat domain protein 17
, ankyrin repeat domain-containing protein 17
, ankyrin repeat domain 17
, ankyrin repeat domain protein 17-like
, ankyrin repeat domain-containing protein 17-like
, gene trap ankyrin repeat protein
, serologically defined breast cancer antigen NY-BR-16
, ankyrin repeat domain containing protein FOE