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BOC is expressed at high levels in adult articular chondrocytes, with a tissue-restricted pattern compared to 11 other adult tissues.
Overweight in mice and enhanced adipogenesis in vitro are associated with lack of the hedgehog (show SHH Proteins) coreceptor boc
Elevated Boc levels induce proliferation of granule cell precursors in early medulloblastoma.
The results of this study proposed that expression of Boc in cells from the ventrotemporal crescent (show SFRP5 Proteins) of the retina is required to sustain Zic2 (show ZIC2 Proteins) expression, likely by regulating the levels of Shh (show SHH Proteins) signaling from the nearby cRGCs. Zic2 (show ZIC2 Proteins).
Cdo (show CDO1 Proteins);Boc double mutants on a largely Cdo (show CDO1 Proteins)-resistant genetic background have lobar holoprosencephaly.
Genetic loss-of-function of GAS1 (show GAS1 Proteins), Cdon (show CDON Proteins) and BOC in SHH (show SHH Proteins) is associated with defective cell proliferation.
Hedgehog (show SHH Proteins) proteins interact with cell adhesion molecule (show MCAM Proteins), down-regulated by oncogenes (CDO (show CDO1 Proteins)) and brother of CDO (BOC) in a conserved manner
Expression of the boc gene during murine embryogenesis
Cdo (show CDO1 Proteins) and Boc bind Shh (show SHH Proteins) through a high-affinity interaction with a specific fibronectin (show FN1 Proteins) repeat that is essential for activity.
data suggest that Boc is essential as a receptor for Shh (show SHH Proteins) in commissural axon guidance
Boc expression increases in subcutaneous white adipose tissue and decreases in intra-abdominal epididymal white adipocytes in obese mice.
Boc receptor is required for segregation of ipsilateral axons at the optic chiasm and, conversely, Boc expression in contralateral retinal ganglion cells prevents their axons from crossing the optic chiasm.
CDO (show CDO1 Proteins) and BOC play a role in differentiation of cells in the skeletal muscle lineage
BOC, along with CDO (show CDO1 Proteins), defines a new subfamily of the immunoglobulin superfamily that is conserved from Drosophila to man. BOC and CDO (show CDO1 Proteins) form a putative receptor complex that stimulates differentiation of myoblasts.
The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation.
, brother of CDO
, Boc homolog (mouse)
, brother of CDO-like
, biregional Cdon binding protein
, brother of CDON
, cell adhesion associated, oncogene regulated 2
, biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein