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Data show that FBXO22 mediated the polyubiquitination and degradation of CD147 by interacting with CD147 intracellular domain (CD147-ICD).
Authors demonstrate that F-box only protein 22 (FBXO22) interacts with and thereby destabilizes KLF4 (show KLF4 Proteins) via polyubiquitination. As a result, FBXO22 could promote HCC (show FAM126A Proteins) cells proliferation.
Results indicate that SCF (show KITLG Proteins)(Fbxo22)-KDM4A (show KDM4A Proteins) is an E3 ubiquitin ligase (show MUL1 Proteins) that targets methylated p53 (show TP53 Proteins) and regulates key senescent processes.
FBXO22 protein is required for optimal synthesis of NMDA receptor coagonist D-serine by interacting with serine racemase (show SRR Proteins), activating it, and preventing its targeting to membranes.
we determined that the phage-encoded GogB effector protein in Salmonella targets the host SCF (show KITLG Proteins) E3 type ubiquitin ligase through an interaction with Skp1 (show SKP1 Proteins) and the human F-box only 22 (FBXO22) protein
FBXO22 is a key regulator of histone methylation marks, namely, H3K9 and H3K36 methylation, through the regulation of KDM4A (show KDM4A Proteins) protein levels.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants.
F-box only protein 22
, F-box protein 22
, f-box only protein 22-like
, F-box protein FBX22p44
, FIST domain containing 1