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results indicate that myogenin (show MYOG Proteins) is a positive regulator in transcriptional regulation of MEGF10 in skeletal muscle
Mutations in MEGF10 cause a recessive congenital myopathy with minicores and suggest satellite cell dysfunction as the pathogenic mechanism
Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD)
The results of this study suggested that no association between schizophrenia and rs27388 of the MEGF10 gene in Chinese case-control sample.
MEGF10 is involved in the uptake of amyloid-beta peptide (Abeta42) in the brain.
in a system of forced expression by transfection, MEGF10 function can be modulated by the ATP binding cassette transporter ABCA1, ortholog to CED-7
Human MEGF10 is an ortholog of Ced1 (show IFT122 Proteins).
An interaction between MEGF10 and clathrin assembly protein complex 2 medium chain (AP50 (show AP2M1 Proteins)), a component of clathrin-coated pits was identified.
In expression studies, MEGF10 had higher expression levels in the affected than the unaffected (p = .015). Schizophrenia patients with a 1/1 genotype at rs27388 had higher expressions than those patients with 1/2 and 2/2 genotypes (p = .0008).
studies reveal a novel role for astrocytes in mediating synapse elimination in the developing and adult brain, identify MEGF10 and MERTK (show MERTK Proteins) as critical proteins in the synapse remodelling underlying neural circuit refinement
Cysteine mutations cause defective tyrosine phosphorylation in MEGF10 myopathy.
These results indicated that both Jedi-1 (show PEAR1 Proteins) and MEGF10 can mediate phagocytosis independently through the recruitment of Syk (show SYK Proteins).
in mouse, two related transmembrane proteins, MEGF10 and MEGF11 (show MEGF11 Proteins), have critical roles in the formation of mosaics by two retinal interneuron subtypes, starburst amacrine cells and horizontal cells
Megf10 represents a novel transmembrane protein that impinges on Notch (show NOTCH1 Proteins) signaling to regulate the satellite cell population balance between proliferation and differentiation.
This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene.
multiple epidermal growth factor-like domains protein 10
, multiple EGF-like domains protein 10