Browse our N-Cadherin Proteins (CDH2)

Full name:
Cadherin 2 Proteins (CDH2)
On www.antibodies-online.com are 25 Cadherin 2 (CDH2) Proteins from 8 different suppliers available. Additionally we are shipping N-Cadherin Antibodies (423) and N-Cadherin Kits (54) and many more products for this protein. A total of 510 N-Cadherin products are currently listed.
Synonyms:
Cadherin-2, CD325, CDH2, CDHN, CDw325, glo, lyr, N-cadherin, NCAD, pac, wu:fb47h04
list all proteins Gene Name GeneID UniProt
CDH2 12558 P15116
CDH2 83501 Q9Z1Y3
CDH2 1000 P19022

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N-Cadherin Proteins (CDH2) by Origin

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Top referenced N-Cadherin Proteins

  1. Human N-Cadherin Protein expressed in Human Cells - ABIN2003757 : LaMora, Voigt: Cranial sensory ganglia neurons require intrinsic N-cadherin function for guidance of afferent fibers to their final targets. in Neuroscience 2009 (PubMed)
    Show all 5 references for 2003757

  2. Human N-Cadherin Protein expressed in Baculovirus infected Insect Cells - ABIN2003756 : Chauvet, El-Yandouzi, Mathieu, Schlernitzauer, Galibert, Lafont, Le Tissier, Robinson, Mollard, Coutry: Characterization of adherens junction protein expression and localization in pituitary cell networks. in The Journal of endocrinology 2009 (PubMed)
    Show all 4 references for 2003756

  3. Mouse (Murine) N-Cadherin Protein expressed in Human Cells - ABIN2008273 : Hartland, Murphy, Aucott, Abergel, Zhou, Waung, Patel, Bradshaw, Collins, Mann, Benyon, Iredale: Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin. in Liver international : official journal of the International Association for the Study of the Liver 2009 (PubMed)
    Show all 4 references for 2008273

  4. Human N-Cadherin Protein expressed in Human Cells - ABIN2003753 : Kohutek, diPierro, Redpath, Hussaini: ADAM-10-mediated N-cadherin cleavage is protein kinase C-alpha dependent and promotes glioblastoma cell migration. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 (PubMed)
    Show all 4 references for 2003753

More Proteins for N-Cadherin Interaction Partners

Xenopus laevis Cadherin 2 (CDH2) interaction partners

  1. the switch from E- to N-cadherin during epithelial-mesenchymal transition is essential for acquisition of Contact inhibition of locomotion behavior.

Mouse (Murine) Cadherin 2 (CDH2) interaction partners

  1. Loss of N-cadherin in the context of oncogenic K-ras leads to increased pancreatic intraepithelial neoplasia (PanIN) incidence and progression.

  2. Type I collagen was highly expressed in the spinal cord during the scar-forming phase and induced astrocytic scar formation via the integrin-N-cadherin pathway.

  3. cadherin 2 (CDH2) and CDH4 (show CDH4 Proteins) cooperate to regulate radial migration in mouse brain via the protein tyrosine phosphatase 1B (PTP1B (show PTPN1 Proteins)) and alpha- and beta-catenins.

  4. N-cadherin-null enteric neural crest cells do not respond to C3a (show C3 Proteins) co-attraction. C3a (show C3 Proteins) regulates cell migration in a N-cadherin-dependent process.

  5. Study demonstrates a critical role of presynaptic cadherin/catenin/p140Cap (show SRCIN1 Proteins) cell adhesion complexes in stabilizing functional synapses and spines in the developing neocortex.

  6. Knock-down of ZBED6 in insulin (show INS Proteins)-producing cells promotes N-cadherin junctions between beta-cells and neural crest stem cells in vitro.

  7. Knockdown of N-cadherin in 3T3 fibroblasts did not impede gap closure in a soft tissue wound healing model.

  8. N-cadherin modulates Lrp6 (show LRP6 Proteins)/PTHR1 (show PTH1R Proteins) interaction, restraining the intensity of parathyroid hormone (show PTH Proteins)-induced beta-catenin (show CTNNB1 Proteins) signaling

  9. Specific deletion of Cdh2 in Sertoli cells leads to altered meiotic progression and subfertility of mice.

  10. CRP (show CRP Proteins) suppresses expression of N-cadherin (p < 0.01), a mesenchymal marker of EMT (show ITK Proteins), and ZEB-1, an EMT (show ITK Proteins)-related transcription factor (p < 0.01). These findings suggest that CRP (show CRP Proteins) inhibits EMT (show ITK Proteins) in a MCA (show RSPH1 Proteins)-38 tumor-bearing mouse model.

Zebrafish Cadherin 2 (CDH2) interaction partners

  1. Newly synthesized N-cadherin molecules move from the lateral to the basal surface of cardiomyocytes during trabeculation. This localization requires Erbb2 (show ERBB2 Proteins) signaling.

  2. Throughout somitogenesis, Cadherin2 promotes extracellular matrix (ECM (show MMRN1 Proteins)) assembly along tissue boundaries and inhibits ECM (show MMRN1 Proteins) assembly in the tissue mesenchyme.

  3. Cdon (show CDON Proteins) is required to localize N-cadherin to the cell membrane in migratory neural crest cells for directed migration.

  4. shows that a dominant-negative nuclear localization mutant of Sox3 (show SOX3 Proteins) can cause ectopic expression of organizer genes via a mechanism that activates all of these earlier factors, resulting in later axis duplication including major bifurcations of the CNS.

  5. Genetic suppression of N-cadherin function interferes with basal migration of retinal progenitors and subsequent regeneration of HuC (show ELAVL3 Proteins)/D(+) inner retinal neurons.

  6. N-cadherin deficiency in Danio does not prevent the first tooth from starting to develop, but stops its development at the early cytodifferentiation stage and completely inhibits the development of the other first-generation teeth.

  7. N-cadherin regulates motor axon growth and branching without severely affecting the mechanisms that control axonal target selection.

  8. Slit-Robo signaling downregulates N-cadherin activity to allow apical retraction in newly generated retinal ganglion cells.

  9. demonstration of a novel mechanism of cell adhesion, mediated by a complex of Protocadherin-19 (Pcdh19 (show PCDH19 Proteins)) and N-cadherin (Ncad)

  10. zebrafish N-cadherin restricts cell proliferation in the dorsal region of the neural tube by regulating cell-cycle length.

Human Cadherin 2 (CDH2) interaction partners

  1. a mechanism where the membrane organization of CD82 (show CD82 Proteins), through specific posttranslational modifications, regulates N-cadherin clustering and membrane density, which impacts the in vivo trafficking of AML (show RUNX1 Proteins) cells.

  2. fluorescent imaging to demonstrate Ncad-mediated single cell responses to developmental cues within hydrogels towards chondrogenesis.

  3. Our data demonstrate that N-Cadherin was markedly overexpressed and miR (show MLXIP Proteins)-199b-5p was significantly downregulated in hepatocellular carcinoma (HCC (show FAM126A Proteins)). MiR (show MLXIP Proteins)-199b-5p exerts inhibitory effects on EMT (show ITK Proteins), and directly targets N-cadherin in HCC (show FAM126A Proteins), supporting the potential utility of miR (show MLXIP Proteins)-199b-5p as a promising strategy to treat HCC (show FAM126A Proteins)

  4. Study demonstrates a critical role of presynaptic cadherin/catenin/p140Cap (show SRCIN1 Proteins) cell adhesion complexes in stabilizing functional synapses and spines in the developing neocortex.

  5. overexpression of SPRY4 (show SPRY4 Proteins)-IT1 (show HAUS3 Proteins) increased E-cadherin (show CDH1 Proteins) and decreased N-cadherin and vimentin (show VIM Proteins) protein levels, indicating that SPRY4 (show SPRY4 Proteins)-IT1 (show HAUS3 Proteins) may regulate ovarian cancer cell metastasis through the inhibition of epithelial-mesenchymal transition.

  6. investigated the in vitro tumor/metastasis suppressor effects of plakoglobin in ovarian cancer cell lines with mutant p53 expression and different cadherin profiles

  7. These results uncover a new role for p120 catenin (show CTNND1 Proteins) bound to the N-cadherin precursor ensuring its trafficking through the biosynthetic pathway towards the cell surface.

  8. Finding that the cells expressing N-cadherin gave rise to tumors with no expression of N-cadherin is in agreement with the classical view of epithelial to mesenchymal transition. Epithelial to mesenchymal transition and N-cadherin are associated with dissemination and not with the ability to establish new tumor growth.

  9. findings suggest that E-cadherin (show CDH1 Proteins) and P-cadherin, but not N-cadherin staining, might be useful in diagnosing CIN (show PDXP Proteins) and for predicting prognosis in patients with early-stage Cervical Squamous Cell Carcinoma.

  10. NKX6.1 (show NKX6-1 Proteins) directly enhances the mRNA level of E-cadherin (show CDH1 Proteins) by recruiting BAF155 (show SMARCC1 Proteins) coactivator and represses that of vimentin (show VIM Proteins) and N-cadherin by recruiting RBBP7 (retinoblastoma binding protein 7 (show RBBP7 Proteins)) corepressor.

N-Cadherin (CDH2) Protein Profile

Protein Summary

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

Alternative names and synonyms associated with N-Cadherin (CDH2)

  • cadherin 2, type 1, N-cadherin (neuronal) (cdh2)
  • cadherin 2 (Cdh2)
  • cadherin 2, neuronal (cdh2)
  • cadherin 2, type 1, N-cadherin (neuronal) (CDH2)
  • cadherin 2, type 1, N-cadherin (neuronal) (Cdh2)
  • cadherin-2-like (LOC100411112)
  • neural-cadherin-like (LOC427547)
  • Cadherin-2 protein
  • CD325 protein
  • CDH2 protein
  • CDHN protein
  • CDw325 protein
  • glo protein
  • lyr protein
  • N-cadherin protein
  • NCAD protein
  • pac protein
  • wu:fb47h04 protein

Protein level used designations for Cadherin 2 Proteins (CDH2)

cadherin 2, type 1, N-cadherin (neuronal) , cadherin-2 , neural cadherin , cadherin 2 type 1 N-cadherin (neuronal) , N-cadherin , Neural cadherin , glass onion , labyrinth , n-cadherin , parachute , N-cadherin 1 , cadherin 2, N-cadherin (neuronal) , calcium-dependent adhesion protein, neuronal , neural-cadherin , cadherin 2, type 1 preproprotein , cadherin-2-like

GENE ID SPECIES
495284 Xenopus laevis
100151712 Xenopus (Silurana) tropicalis
12558 Mus musculus
83501 Rattus norvegicus
100689204 Cricetulus griseus
30291 Danio rerio
1000 Homo sapiens
414745 Gallus gallus
281062 Bos taurus
480169 Canis lupus familiaris
100286861 Sus scrofa
101082701 Felis catus
100065078 Equus caballus
100170321 Ovis aries
100328895 Oryctolagus cuniculus
100714783 Cavia porcellus
100411112 Callithrix jacchus
427547 Gallus gallus
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