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Browse our N-Cadherin Proteins (CDH2)

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Cadherin 2 Proteins (CDH2)
On are 15 Cadherin 2 (CDH2) Proteins from 5 different suppliers available. Additionally we are shipping N-Cadherin Antibodies (384) and N-Cadherin Kits (36) and many more products for this protein. A total of 443 N-Cadherin products are currently listed.
Cadherin-2, CD325, CDH2, CDHN, CDw325, glo, lyr, N-cadherin, NCAD, pac, wu:fb47h04
list all proteins Gene Name GeneID UniProt
CDH2 12558 P15116
Rat CDH2 CDH2 83501 Q9Z1Y3
CDH2 1000 P19022

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N-Cadherin Proteins (CDH2) by Origin

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Top referenced N-Cadherin Proteins

  1. Human N-Cadherin Protein expressed in Human Cells - ABIN2003757 : LaMora, Voigt: Cranial sensory ganglia neurons require intrinsic N-cadherin function for guidance of afferent fibers to their final targets. in Neuroscience 2009 (PubMed)
    Show all 5 references for ABIN2003757

  2. Human N-Cadherin Protein expressed in Baculovirus infected Insect Cells - ABIN2003756 : Chauvet, El-Yandouzi, Mathieu, Schlernitzauer, Galibert, Lafont, Le Tissier, Robinson, Mollard, Coutry: Characterization of adherens junction protein expression and localization in pituitary cell networks. in The Journal of endocrinology 2009 (PubMed)
    Show all 4 references for ABIN2003756

  3. Mouse (Murine) N-Cadherin Protein expressed in Human Cells - ABIN2008273 : Hartland, Murphy, Aucott, Abergel, Zhou, Waung, Patel, Bradshaw, Collins, Mann, Benyon, Iredale: Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin. in Liver international : official journal of the International Association for the Study of the Liver 2009 (PubMed)
    Show all 4 references for ABIN2008273

  4. Human N-Cadherin Protein expressed in Human Cells - ABIN2003753 : Kohutek, diPierro, Redpath, Hussaini: ADAM-10-mediated N-cadherin cleavage is protein kinase C-alpha dependent and promotes glioblastoma cell migration. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 (PubMed)
    Show all 4 references for ABIN2003753

More Proteins for N-Cadherin Interaction Partners

Xenopus laevis Cadherin 2 (CDH2) interaction partners

  1. the switch from E- to N-cadherin during epithelial-mesenchymal transition is essential for acquisition of Contact inhibition of locomotion behavior.

Mouse (Murine) Cadherin 2 (CDH2) interaction partners

  1. Knock-down of ZBED6 in insulin (show INS Proteins)-producing cells promotes N-cadherin junctions between beta-cells and neural crest stem cells in vitro.

  2. Knockdown of N-cadherin in 3T3 fibroblasts did not impede gap closure in a soft tissue wound healing model.

  3. N-cadherin modulates Lrp6 (show LRP6 Proteins)/PTHR1 (show PTH1R Proteins) interaction, restraining the intensity of parathyroid hormone (show PTH Proteins)-induced beta-catenin (show CTNNB1 Proteins) signaling

  4. Specific deletion of Cdh2 in Sertoli cells leads to altered meiotic progression and subfertility of mice.

  5. CRP (show CRP Proteins) suppresses expression of N-cadherin (p < 0.01), a mesenchymal marker of EMT (show ITK Proteins), and ZEB-1, an EMT (show ITK Proteins)-related transcription factor (p < 0.01). These findings suggest that CRP (show CRP Proteins) inhibits EMT (show ITK Proteins) in a MCA (show RSPH1 Proteins)-38 tumor-bearing mouse model.

  6. these studies suggest that N-cadherin may represent a viable therapeutic target to prevent the dissemination of MM PCs and delay MM disease progression.

  7. N-cadherin is required for the establishment and maintenance of anterior heart field -cardiac progenitor cells.

  8. delta-Catenin Regulates Spine Architecture via Cadherin and PDZ-dependent Interactions.

  9. Results demonstrate a novel function for the N-cadherin/beta-catenin (show CTNNB1 Proteins) complex in regulating ionotropic receptor composition of excitatory synapses

  10. N-cadherin is not essential for healthy enamel development and does not significantly affect the mineralization process.

Zebrafish Cadherin 2 (CDH2) interaction partners

  1. Throughout somitogenesis, Cadherin2 promotes extracellular matrix (ECM (show MMRN1 Proteins)) assembly along tissue boundaries and inhibits ECM (show MMRN1 Proteins) assembly in the tissue mesenchyme.

  2. Cdon (show CDON Proteins) is required to localize N-cadherin to the cell membrane in migratory neural crest cells for directed migration.

  3. shows that a dominant-negative nuclear localization mutant of Sox3 (show SOX3 Proteins) can cause ectopic expression of organizer genes via a mechanism that activates all of these earlier factors, resulting in later axis duplication including major bifurcations of the CNS.

  4. Genetic suppression of N-cadherin function interferes with basal migration of retinal progenitors and subsequent regeneration of HuC (show ELAVL3 Proteins)/D(+) inner retinal neurons.

  5. N-cadherin deficiency in Danio does not prevent the first tooth from starting to develop, but stops its development at the early cytodifferentiation stage and completely inhibits the development of the other first-generation teeth.

  6. N-cadherin regulates motor axon growth and branching without severely affecting the mechanisms that control axonal target selection.

  7. Slit-Robo signaling downregulates N-cadherin activity to allow apical retraction in newly generated retinal ganglion cells.

  8. demonstration of a novel mechanism of cell adhesion, mediated by a complex of Protocadherin-19 (Pcdh19 (show PCDH19 Proteins)) and N-cadherin (Ncad)

  9. zebrafish N-cadherin restricts cell proliferation in the dorsal region of the neural tube by regulating cell-cycle length.

  10. Protocadherin-19 (show PCDH19 Proteins) and N-cadherin interact to control cell movements during anterior neurulation

Human Cadherin 2 (CDH2) interaction partners

  1. High expression of N-cadherin is associated with bladder cancer.

  2. Snail (show SNAI1 Proteins) and N-cadherin are constitutively and inducibly expressed in papillary thyroid carcinoma

  3. SFMSCs increased through upregulation of the activated lymphocyte cell adhesion molecule (show MCAM Proteins) (ALCAM (show ALCAM Proteins)) and N-cadherin by microRNA-192 and -218 downregulation, similar to BMMSCs and ADMSCs.

  4. the synergy between N-cadherin and FGFR (show FGFR2 Proteins) signalling that ensure cellular reorganization during cell movements, mainly during cancer cell migration and metastasis but also during developmental processes.

  5. Underexpression of CDH2 is associated with adrenocortical tumors.

  6. Data show that gene silence of ezrin (show EZR Proteins) inhibits the proliferation and invasion of prostate cancer PC-3 (show PCSK1 Proteins) cells, meanwhile the level of E-cadherin (show CDH1 Proteins) is upregulated and N-cadherin is downregulated.

  7. These data suggest that the number of polyploid giant cancer cells and the EMT (show ITK Proteins)-related proteins E-cadherin (show CDH1 Proteins), N-cadherin, and vimentin (show VIM Proteins) may be valuable biomarkers to assess metastasis in patients with breast cancer.

  8. Targeting N-cadherin may be a promising therapeutic approach, particularly in cisplatin-resistant, therapy refractory and metastatic Germ cell tumor.

  9. Metformin's anti-cancer therapeutic effect is mediated through different molecular mechanism in wild-type vs. deficient N-cadherin cancer cells.

  10. Data show that grape seed proanthocyanidins could inhibit cell proliferation, invasion and migration of A549 cells, which might be related to the down-regulation of epidermal growth factor receptor (show EGFR Proteins) and N-cadherin and the up-regulation of E-cadherin (show CDH1 Proteins).

N-Cadherin (CDH2) Protein Profile

Protein Summary

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

Alternative names and synonyms associated with N-Cadherin (CDH2)

  • cadherin 2, type 1, N-cadherin (neuronal) (cdh2)
  • cadherin 2 (Cdh2)
  • cadherin 2, neuronal (cdh2)
  • cadherin 2, type 1, N-cadherin (neuronal) (CDH2)
  • cadherin 2, type 1, N-cadherin (neuronal) (Cdh2)
  • cadherin-2-like (LOC100411112)
  • neural-cadherin-like (LOC427547)
  • Cadherin-2 protein
  • CD325 protein
  • CDH2 protein
  • CDHN protein
  • CDw325 protein
  • glo protein
  • lyr protein
  • N-cadherin protein
  • NCAD protein
  • pac protein
  • wu:fb47h04 protein

Protein level used designations for Cadherin 2 Proteins (CDH2)

cadherin 2, type 1, N-cadherin (neuronal) , cadherin-2 , neural cadherin , cadherin 2 type 1 N-cadherin (neuronal) , N-cadherin , Neural cadherin , glass onion , labyrinth , n-cadherin , parachute , N-cadherin 1 , cadherin 2, N-cadherin (neuronal) , calcium-dependent adhesion protein, neuronal , neural-cadherin , cadherin 2, type 1 preproprotein , cadherin-2-like

495284 Xenopus laevis
100151712 Xenopus (Silurana) tropicalis
12558 Mus musculus
83501 Rattus norvegicus
100689204 Cricetulus griseus
30291 Danio rerio
1000 Homo sapiens
414745 Gallus gallus
281062 Bos taurus
480169 Canis lupus familiaris
100286861 Sus scrofa
101082701 Felis catus
100065078 Equus caballus
100170321 Ovis aries
100328895 Oryctolagus cuniculus
100714783 Cavia porcellus
100411112 Callithrix jacchus
427547 Gallus gallus
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