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the present study demonstrates that mice with the R141C point mutation in the Nkx2.5 allele phenocopies humans with the NKX2.5 R142C point mutation.
Using a combination of mouse genetics, biochemistry, molecular and cell biology, we demonstrate that Nkx2-5 regulates the gene encoding Kcnh2 (show KCNH2 Antibodies) channel and others, shedding light on potential mechanisms generating electrical abnormalities observed in patients bearing NKX2-5 dysfunction and opening opportunities to the study of novel therapeutic targets for anti-arrhythmogenic therapies
In the absence of NKX2-5 (or Smad-6 (show SMAD6 Antibodies)), a severe form of rheumatic heart disease is observed.
Study reports extensive and complex interdependent genomic occupancy of TBX5 (show TBX5 Antibodies), NKX2-5, and the zinc finger TF GATA4 (show GATA4 Antibodies) coordinately controlling cardiac gene expression, differentiation, and morphogenesis.
Sequential binding of MEIS1 (show MEIS1 Antibodies) and NKX2-5 on the Popdc2 (show POPDC2 Antibodies) gene demonstrate a mechanism for spatiotemporal regulation of enhancers during cardiogenesis.
The model proposed will help to elucidate the molecular basis for disease causing mutations in GATA4 and NKX2-5 and may be relevant to other members of the GATA and NK classes of transcription factors.
MSCs thus form a 'mechanical memory' of rigidity by progressively suppressing NKX2.5, thereby elevating SMA (show SMN1 Antibodies) in a scar-like state.
the Shox2 (show SHOX2 Antibodies)-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node
Findings implicate a novel, temporal-specific role of Mzf1 (show ZSCAN1 Antibodies) in embryonic heart development and show that Mzf1 (show ZSCAN1 Antibodies) bounds directly to the Nkx2.5 during murine embryonic stem cell differentiation.
A heterozygous Nkx2-5 missense mutation in the homeodomain demonstrates a high penetrance of diverse cardiac anomalies, similar to or more profound than those observed in human patients.
Nkx2-5 mutations cause heart defects in Xenopus laevis
HIF-1alpha (show HIF1A Antibodies)-regulated nkx2.5 expression is required for heart development in Xenopus
we would like to suggest that FGF expressed in anterior neural ectoderm is a major inducer of Nkx2.5 expression in neighboring cells
These findings validate HRV analysis as a useful quantitative tool for assessment of cardiac health in zebrafish and underscore the importance of nkx2.5 in maintaining normal heart rate and HRV during early conduction system development.
Nkx2.5 is required for proper craniofacial development in zebrafish and acts in part by upregulating ece1 (show ECE1 Antibodies) expression.
An early requirement for nkx2.5 ensures the first and second heart field ventricular identity and cardiac function into adulthood.
Flanking a transgenic construct by chicken HS4 insulation sequences from beta globin (show HBB Antibodies) leads to overall increase in the expression of nkx2.5:mRFP.
studies reveal the heart field origin of PAA endothelium and attribute a new vasculogenic function to the cardiac transcription factor Nkx2.5 during great vessel precursor development
findings show that the homeodomain transcription factors Nkx2.5 and Nkx2.7 are necessary to sustain ventricular chamber attributes through repression of atrial chamber identity.
Embryos injected with an nkx2.5 morpholino exhibited SHF phenotypes caused by compromised progenitor cell proliferation. Co-injecting low doses of nkx2.5 and ltbp3 morpholinos revealed a genetic interaction between these factors.
The cardiac connexin Ecx and its downstream signaling are crucial for establishing nkx2.5 expression, which in turn promotes unidirectional, parallel alignment of myofibrils and the subsequent proper heart morphogenesis.[
redundant activities of Nkx2.5 and Nkx2.7 are required for cardiac morphogenesis (show XIRP1 Antibodies), but Nkx2.7 plays a more critical function, regulating the expressions of tbx5 (show TBX5 Antibodies) and tbx20 (show TBX20 Antibodies) through the maturation stage
Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4.
Drosophila NK2 transcription factor related, locus 5
, NK2 transcription factor related, locus 5
, cardiac-specific homeobox
, homeobox protein CSX
, homeobox protein NK-2 homolog E
, homeobox protein Nkx-2.5
, NK2 transcription factor related 5 b
, tinman homeobox homolog