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NK2 Homeobox 5 ELISA Kits (NKX2-5)
On www.antibodies-online.com are 0 NK2 Homeobox 5 (NKX2-5) ELISA Kits from different suppliers available. Additionally we are shipping NK2 Homeobox 5 Antibodies (126) and NK2 Homeobox 5 Proteins (5) and many more products for this protein. A total of 140 NK2 Homeobox 5 products are currently listed.
Synonyms:
CHNG5, CNKX-2.5, Csx, CSX1, HLHS2, NKX-2.5, Nkx2-5, NKX2.5, NKX2E, NKX4-1, tinman, VSD3, XNkx-2.5, XNkx2-5
list all ELISA KIts Gene Name GeneID UniProt
Human NKX2-5 NKX2-5 1482 P52952
Mouse NKX2-5 NKX2-5 18091 P42582
Rat NKX2-5 NKX2-5 114109 O35767

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More ELISA Kits for NK2 Homeobox 5 Interaction Partners

Human NK2 Homeobox 5 (NKX2-5) interaction partners

  1. There is no difference in NKX2.5 and TBX5 (show TBX5 ELISA Kits) gene mutations between in vitro fertilization and naturally conceived children with congenital heart disease.

  2. This study is the first to associate NKX2-5 loss-of-function mutations with enhanced susceptibility to sporadic DCM, which provides novel insight into the molecular etiology underpinning DCM

  3. Hence, the variant distribution of NKX2-5, GATA4 (show GATA4 ELISA Kits) and TBX5 (show TBX5 ELISA Kits) are tightly associated with particular Congenital heart disease subtypes. Further structure-modelling analysis revealed that these mutated amino acid residuals maintain their DNA-binding ability and structural stability

  4. The results of the present study expand the spectrum of NKX2.5 mutations linked to congenital atrial septal defect and atrioventricular block, and indicated that NKX2.5 lossoffunction mutations are an uncommon cause of congenital atrial septal defect and atrioventricular block in humans.

  5. I184F-NK2 homeobox 5 homeobox protein is a novel variant associated with congenital heart disease.

  6. NKX2-5 mutations mainly occur in familial congenital heart defects, the signature phenotype is atrial septal defects with conduction disturbances and mutation carriers are at increased risk of sudden cardiac death.

  7. 187QNRRYKCKRQR197 was required for exclusive nuclear localization of NKX2.5.

  8. NKX2.5 and GATA4 (show GATA4 ELISA Kits) gene mutations might participate in the development of congenital heart disease and can promote bone marrow derived stroma cell differentiate into cardiomyocytes.

  9. Data indicate that cells cultured on cardiac muscle laminin (LN)-based substrata in combination with stimulation of the canonical Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) pathway showed increased gene expression of ISL1 (show ISL1 ELISA Kits), OCT4 (show POU5F1 ELISA Kits), KDR (show KDR ELISA Kits) and NKX2.5.

  10. There was no evidence of a role for NKX2-5 and GATA4 (show GATA4 ELISA Kits) CNV in fetal CHD (show CHDH ELISA Kits); therefore, these CNV may not be common in fetal CHD (show CHDH ELISA Kits) in China

Mouse (Murine) NK2 Homeobox 5 (NKX2-5) interaction partners

  1. the present study demonstrates that mice with the R141C point mutation in the Nkx2.5 allele phenocopies humans with the NKX2.5 R142C point mutation.

  2. Using a combination of mouse genetics, biochemistry, molecular and cell biology, we demonstrate that Nkx2-5 regulates the gene encoding Kcnh2 (show KCNH2 ELISA Kits) channel and others, shedding light on potential mechanisms generating electrical abnormalities observed in patients bearing NKX2-5 dysfunction and opening opportunities to the study of novel therapeutic targets for anti-arrhythmogenic therapies

  3. In the absence of NKX2-5 (or Smad-6 (show SMAD6 ELISA Kits)), a severe form of rheumatic heart disease is observed.

  4. Study reports extensive and complex interdependent genomic occupancy of TBX5 (show TBX5 ELISA Kits), NKX2-5, and the zinc finger TF GATA4 (show GATA4 ELISA Kits) coordinately controlling cardiac gene expression, differentiation, and morphogenesis.

  5. Sequential binding of MEIS1 (show MEIS1 ELISA Kits) and NKX2-5 on the Popdc2 (show POPDC2 ELISA Kits) gene demonstrate a mechanism for spatiotemporal regulation of enhancers during cardiogenesis.

  6. The model proposed will help to elucidate the molecular basis for disease causing mutations in GATA4 and NKX2-5 and may be relevant to other members of the GATA and NK classes of transcription factors.

  7. MSCs thus form a 'mechanical memory' of rigidity by progressively suppressing NKX2.5, thereby elevating SMA (show SMN1 ELISA Kits) in a scar-like state.

  8. the Shox2 (show SHOX2 ELISA Kits)-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node

  9. Findings implicate a novel, temporal-specific role of Mzf1 in embryonic heart development and show that Mzf1 bounds directly to the Nkx2.5 during murine embryonic stem cell differentiation.

  10. A heterozygous Nkx2-5 missense mutation in the homeodomain demonstrates a high penetrance of diverse cardiac anomalies, similar to or more profound than those observed in human patients.

NK2 Homeobox 5 (NKX2-5) Antigen Profile

Antigen Summary

This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with NK2 Homeobox 5 (NKX2-5)

  • NK2 transcription factor related, locus 5 (Drosophila) (NKX2-5) Elisa Kit
  • Nkx2.5 protein (nkx2.5) Elisa Kit
  • NK2 transcription factor related, locus 5 (nkx2-5) Elisa Kit
  • NK2 homeobox 5 (NKX2-5) Elisa Kit
  • NK2 homeobox 5 (Nkx2-5) Elisa Kit
  • Nkx-2.5 homeobox protein (NKX-2.5) Elisa Kit
  • CHNG5 Elisa Kit
  • CNKX-2.5 Elisa Kit
  • Csx Elisa Kit
  • CSX1 Elisa Kit
  • HLHS2 Elisa Kit
  • NKX-2.5 Elisa Kit
  • Nkx2-5 Elisa Kit
  • NKX2.5 Elisa Kit
  • NKX2E Elisa Kit
  • NKX4-1 Elisa Kit
  • tinman Elisa Kit
  • VSD3 Elisa Kit
  • XNkx-2.5 Elisa Kit
  • XNkx2-5 Elisa Kit

Protein level used designations for NK2 Homeobox 5 (NKX2-5) ELISA Kits

NK2 transcription factor related, locus 5 (Drosophila) , NK2 transcription factor locus 5-like , Nkx2.5 protein , NK2 transcription factor related, locus 5 , cardiac-specific homeobox 1 , homeobox protein CSX , homeobox protein NK-2 homolog E , homeobox protein Nkx-2.5 , tinman paralog , transcription factor NKX2.5 , Drosophila NK2 transcription factor related, locus 5 , cardiac-specific homeobox , rNKx-2.5

GENE ID SPECIES
462273 Pan troglodytes
703795 Macaca mulatta
100026700 Monodelphis domestica
100125478 Oryzias latipes
100144646 Xenopus (Silurana) tropicalis
1482 Homo sapiens
489113 Canis lupus familiaris
538870 Bos taurus
18091 Mus musculus
114109 Rattus norvegicus
396073 Gallus gallus
100009490 Oryctolagus cuniculus
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