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In non-small cell lung cancer, SOX8 expression was elevated, and correlated with tumor size, lymph node metastasis, clinical stage and differentiation classification.
Suggest that miRNA-124 may regulate non-small cell lung carcinoma cell proliferation via decreasing SOX8.
SOX8 mRNA levels decrease during in vitro dedifferentiation of human articular chondrocytes and increase during chondrogenic differentiation of mesenchymal stromal cells.
SOX8 promotes cancer cell proliferation and its expression is correlated with elevated beta-catenin (show CTNNB1 ELISA Kits) levels in hepatocellular carcinoma
The SOX8 single nucleotide polymorphism, rs2744148, is associated with increased genetic risk for multiple sclerosis.
Quantitative changes of enteric glia represented by SOX8 provide a basis for pathological assessment of glial proliferation and/or degeneration in the diseased gut (show GUSB ELISA Kits).
SOX2 (show SOX2 ELISA Kits) and SOX17 (show SOX17 ELISA Kits) expression patterns can distinguish between seminoma and embryonal carcinoma, and this distinction may be diagnostically useful.
Concluding, this study shows that, in addition to its crucial role in testis development, Sox9 (show SOX9 ELISA Kits), together with Sox8 and coordinately with Dmrt1 (show DMRT1 ELISA Kits), also controls adult testis maintenance.
Binding of mrhl RNA to the Sox8 promoter is accompanied by the assembly of other regulatory factors involving Myc (show MYC ELISA Kits)-Max-Mad transcription factors, corepressor Sin3a, and coactivator Pcaf (show KAT2B ELISA Kits)
These results suggest that Sox8 is essential in Sertoli cells for germ cell differentiation, partly by controlling the microenvironment of the seminiferous epithelium.
combined RNA profiling signals, motif predictions and network data identified putative SOX8/SOX9 (show SOX9 ELISA Kits) target genes in Sertoli cells and yielded insight into regulatory interactions that depend upon these transcription factors
Sox9 (show SOX9 ELISA Kits) and Sox8 maintain integrity of the basal lamina to prevent testis cord disintegration and both factors actively suppress the ovarian program during early testis development.
Seven regions near the Sox8 gene as potential enhancers, were identified.
SOX8 has a role in testis differentiation in mice and synergizes with SF1 (show SF1 ELISA Kits) to activate the Amh (show AMH ELISA Kits) promoter in vitro
Sox8 acts as a specific negative regulator of skeletal muscle differentiation, possibly by interfering with the function of myogenic basic helix-loop-helix proteins
Results suggest that Sox8 reinforces Sox9 (show SOX9 ELISA Kits) function in testis differentiation of mice.
Sox8-deficient mice thus exhibited a similar, but less severe phenotype than did Sox10 (show SOX10 ELISA Kits)-deficient mice wiwth regard to oligodendrocyte differentiation.
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome).
transcription factor SOX-8
, SRY-box containing gene 8
, transcription factor Sox-8
, SOX8 transcription factor