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Browse our TACR1 Proteins (TACR1)

Full name:
Tachykinin Receptor 1 Proteins (TACR1)
On are 11 Tachykinin Receptor 1 (TACR1) Proteins from 4 different suppliers available. Additionally we are shipping TACR1 Antibodies (151) and TACR1 Kits (43) and many more products for this protein. A total of 211 TACR1 products are currently listed.
ASPR, nk1R, NKIR, Spr, Tac1r, Tacr1
list all proteins Gene Name GeneID UniProt
TACR1 6869 P25103
TACR1 21336 P30548
Rat TACR1 TACR1 24807 P14600

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TACR1 Proteins (TACR1) by Origin

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Top referenced TACR1 Proteins

  1. Human TACR1 Protein expressed in Escherichia coli (E. coli) - ABIN1047692 : Takeda, Chou, Takeda, Sachais, Krause: Molecular cloning, structural characterization and functional expression of the human substance P receptor. in Biochemical and biophysical research communications 1991 (PubMed)
    Show all 2 references for ABIN1047692

More Proteins for TACR1 Interaction Partners

Human Tachykinin Receptor 1 (TACR1) interaction partners

  1. Expression substance P/neurokinin A (show TAC1 Proteins)/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 (show TAC1 Proteins) receptors are dysregulated in uterine leiomyomata.

  2. results suggest that ARRB1 (show ARRB1 Proteins) plays an essential role in NK1R-mediated cell proliferation and G2/M transition in glioblastoma cells. Interference with ARRB1 (show ARRB1 Proteins)-mediated signaling via NK1R may have potential significance for therapeutic strategies targeting glioblastoma.

  3. Data suggest that endogenous tachykinin ligands for neurokinin-1 receptor exhibit large variations in binding/activation kinetics; substance P (show TAC1 Proteins) exhibits fast association kinetics; neurokinin A (show TAC1 Proteins) exhibits slow association kinetics.

  4. We showed that pretreating a cardiomyocyte cell line (H9C2) and a TNBC cell line (MDA-MB 231) with aprepitant, a SP receptor antagonist that is routinely used to treat chemotherapy-associated nausea, decreased DOX-induced reduction of viability, apoptotic cell death, and ROS (show ROS1 Proteins) production in cardiomyocytes

  5. These findings reveal important insight into the molecular mechanisms of the NK1R complex as a critical component in a model of pediatric liver cancer and may support the development of novel therapeutic interventions for hepatoblastoma

  6. Neuropeptide signaling through neurokinin-1 (show TAC1 Proteins) and neurokinin-2 (show TAC1 Proteins) receptors augments antigen presentation by human dendritic cells

  7. Inhibition of CaV2.3 (show CACNA1E Proteins) channels by NK1 (show CD160 Proteins) receptors is sensitive to membrane cholesterol but insensitive to caveolin-1 (show CAV1 Proteins).

  8. NK-1 (show CD160 Proteins) activation could enhance EGFR (show EGFR Proteins) expression and phosphorylation, and then activate EGFR (show EGFR Proteins) related Erk/MAPK (show MAPK1 Proteins) and Akt (show AKT1 Proteins) pathway.

  9. The single nucleotide polymorphisms in the TACR1 gene are associated with sex differences in postoperative nausea and vomiting.

  10. Results show the existence of a relevant alteration in NK-1R expression in bipolar disorder patients and further suggest Substance P (show TAC1 Proteins) involvement in BD.

Mouse (Murine) Tachykinin Receptor 1 (TACR1) interaction partners

  1. the NK1R-CreER mouse line is a valuable new tool for conditional gene manipulation enabling the visualization and manipulation of cells that express NK1R.

  2. NK1R-/- mice did not exhibit excessive false alarms, compared with wildtypes (response disinhibition) but, as in the 5-Choice ContinuousPerformance Test, they exhibited more perseverative responses throughout the test

  3. NK1R-expressing dorsal horn neurons play a major role in the expression of symptoms of chronic itch.

  4. The results of this study indicated that certain behaviours, disrupted in ADHD, are influenced by an interaction between the BRAS and NK1R, and suggest that ACE (show ACE Proteins) inhibitors could provide a novel treatment for this disorder.

  5. Results provide evidence linking enhanced waking activity and the pro-inflammatory molecule substance P (show TAC1 Proteins) to changes in slow-wave activity associated with sleep-active cortical cells that co-express nNOS (show NOS1 Proteins) and the NK-1R

  6. the hyperactivity, perseveration and, possibly, inattentiveness of NK1R-/- mice is a direct consequence of a lack of functional NK1R

  7. Substance P (show TAC1 Proteins) partly accounts for the increased density of microglia in the substantia nigra through chemotaxic recruitment via a novel NK1R-NOX2 (show CYBB Proteins) axis-mediated pathway.

  8. NK1 (show HGF Proteins)-R expression in the trachea, bronchus, and lung tissue increased in MP-infected BALB/c mice, which may explain why wheezing occurs after MP infection.

  9. The behavioural response of mice lacking NK1r to guanfacine resembles its clinical profile in treatment of ADHD

  10. Together, our findings revealed a critical role of microglial NOX2 (show CYBB Proteins) in mediating the neuroinflammatory and dopaminergic neurodegenerative effects of SP, which may provide new insights into the pathogenesis of PD.

Rabbit Tachykinin Receptor 1 (TACR1) interaction partners

  1. Implanting vascular bundles into the tissue engineered bone can significantly improve the expression levels of NK1R and VIPR1 (show VIPR1 Proteins).

Guinea Pig Tachykinin Receptor 1 (TACR1) interaction partners

  1. Activation of neurokinin-1 (show TAC1 Proteins) receptors in primary sensory neurons plays a role in the generation of overactive bladder.

  2. Substance P (show TAC1 Proteins) and SP-R mRNA expressions were reduced after IMETIT treatment of allergic rhinitis.

TACR1 Protein Profile

Protein Summary

This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P.

Alternative names and synonyms associated with TACR1

  • substance-P receptor-like (LOC100053491)
  • tachykinin receptor 1 (TACR1)
  • tachykinin receptor 1 (Tacr1)
  • ASPR protein
  • nk1R protein
  • NKIR protein
  • Spr protein
  • Tac1r protein
  • Tacr1 protein

Protein level used designations for Tachykinin Receptor 1 Proteins (TACR1)

NK-1 receptor , NK-1R , substance-P receptor , tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor) , Nk1 receptor , neurokinin receptor 1 , substance P receptor , SPR , neurokinin 1 receptor , substance p receptor , neurokinin receptor subtype NK1 , tachikinin receptor 1 , tachykinin receptor 1 , neurokinin-1 receptor

100053491 Equus caballus
6869 Homo sapiens
21336 Mus musculus
24807 Rattus norvegicus
403815 Canis lupus familiaris
407133 Bos taurus
100357296 Oryctolagus cuniculus
100135626 Cavia porcellus
395677 Gallus gallus
101122011 Ovis aries
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