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Browse our anti-DGCR8 (DGCR8) Antibodies

Full name:
anti-DiGeorge Syndrome Critical Region Gene 8 Antibodies (DGCR8)
On www.antibodies-online.com are 70 DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibodies from 14 different suppliers available. Additionally we are shipping DGCR8 Proteins (5) and many more products for this protein. A total of 87 DGCR8 products are currently listed.
Synonyms:
C22orf12, D16H22S788E, D16H22S1742E, D16Wis2, DGCR8, DGCRK6, Gy1, MGC78846, N41, pasha, si:ch211-106a19.4, Vo59c07, wu:fc23f08, wu:fc38f06
list all antibodies Gene Name GeneID UniProt
DGCR8 54487 Q8WYQ5
DGCR8 94223 Q9EQM6
DGCR8 287954  

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anti-Human DGCR8 Antibodies:

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Top referenced anti-DGCR8 Antibodies

  1. Chicken Polyclonal DGCR8 Primary Antibody for IHC, WB - ABIN2776557 : Shiohama, Sasaki, Noda, Minoshima, Shimizu: Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins. in Experimental cell research 2007 (PubMed)
    Show all 3 references for ABIN2776557

  2. Human Polyclonal DGCR8 Primary Antibody for ELISA, WB - ABIN565740 : Luers, Loudig, Berman: MicroRNAs are expressed and processed by human primary macrophages. in Cellular immunology 2010 (PubMed)

  3. Human Polyclonal DGCR8 Primary Antibody for IF, WB - ABIN527085 : Márquez, Kohli, Arteta, Chang, Li, Goldblatt, Vidal-Vanaclocha: Identification of hepatic microvascular adhesion-related genes of human colon cancer cells using random homozygous gene perturbation. in International journal of cancer. Journal international du cancer 2013 (PubMed)

More Antibodies against DGCR8 Interaction Partners

Human DiGeorge Syndrome Critical Region Gene 8 (DGCR8) interaction partners

  1. Results demonstrated that DGCR8 is significantly upregulated in invasive ductal breast carcinoma, suggesting that increased expression of DGCR8 may play a fundamental role during the process of breast carcinogenesis.

  2. DGCR8 and Drosha (show DROSHA Antibodies) assemble into a heterotrimeric complex on RNA, comprising two DGCR8 molecules and one Drosha (show DROSHA Antibodies) molecule.

  3. Results show that DGCR8 forms an alternative complex with the RRP6 (show EXOSC10 Antibodies)-containing form of the exosome, acts as an adaptor to recruit the exosome to target structured RNAs, and the DGCR8/hRRP6 complex controls the stability of human telomerase RNA.

  4. We aimed to evaluate the expression of the major components of microRNA biogenesis machinery including Drosha (show DROSHA Antibodies), Dicer (show DICER1 Antibodies) and DiGeorge syndrome critical region gene 8 (DGCR8) in multiple sclerosis patients

  5. These results reveal a new pathway in the DNA damage response wherein ABL (show ABL1 Antibodies)-dependent tyrosine phosphorylation of DGCR8 stimulates the processing of selective primary miRNAs.

  6. DGCR8 functions as an oncogene (show RAB1A Antibodies) in ovarian cancer, which is in part mediated by miR (show MLXIP Antibodies)-27b.

  7. Together with a 23-amino acid peptide from DGCR8, DROSHA (show DROSHA Antibodies) constitutes a minimal functional core. DROSHA (show DROSHA Antibodies) serves as a "ruler" by measuring 11 bp from the basal ssRNA-dsRNA junction. DGCR8 interacts with the stem and apical elements through its dsRNA-binding domains and RNA-binding heme domain, respectively, allowing efficient and accurate processing.

  8. Data show decreased DGCR8 expression and miRNA dysregulation in individuals with 22q11.2 deletion syndrome

  9. These data show that hepatitis B virus proteins repress DGCR8 promoter activity by upregulating the expression of transcription factor YY1 (show YY1 Antibodies).

  10. in tumors with DGCR8 E518K and DROSHA (show DROSHA Antibodies) exon 29 (miRNAPG-HS) mutations ... greater prevalence of tumors with blastemal predominant histology in patients with miRNAPG-HS and/or SIX1 (show SIX1 Antibodies)/2 Q177R mutations

Mouse (Murine) DiGeorge Syndrome Critical Region Gene 8 (DGCR8) interaction partners

  1. DGCR8 is required for the progression, but not initiation, of Akt (show AKT1 Antibodies) induced prostate cancer in vivo.

  2. DGCR8 is required for microRNA biogenesis and normal mouse embryonic stem cell proliferation and differentiation.

  3. These results reveal a new pathway in the DNA damage response wherein ABL (show ABL1 Antibodies)-dependent tyrosine phosphorylation of DGCR8 stimulates the processing of selective primary miRNAs.

  4. Conditional gene deletion of the essential miRNA-processing enzyme Dgcr8 in the developing renal tubular system results in severe developmental defects and kidney failure.

  5. Dgcr8 is responsible for modulation of gene expression programs underlying myelin formation and maintenance as well as suppression of an injury-related gene expression program

  6. Dgcr8 mutant mice, which have a defective miRNA pathway while retaining an intact endo-siRNA pathway, were infertile and displayed cumulative defects in meiotic and haploid phases of spermatogenesis, resulting in oligo-, terato-, and azoospermia.

  7. Adipose tissue-specific Dgcr8 knockout mice displayed enlarged but pale interscapular brown fat with decreased expression of genes characteristic of brown fat and were intolerant to cold exposure.

  8. Data indicate that DiGeorge syndrome critical region gene 8 (DGCR8)-dependent miRs are indispensable for osteoclastic control of bone metabolism.

  9. This suggests that Dgcr8-microRNA-Drd2 (show DRD2 Antibodies)-dependent thalamocortical disruption is a pathogenic event underlying schizophrenia-associated psychosis.

  10. These data reveal a role for DeltaNp63 in the transcriptional regulation of DGCR8 to reprogram adult somatic cells into multipotent stem cells.

DGCR8 Antigen Profile

Antigen Summary

This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with DGCR8

  • DiGeorge syndrome critical region gene 8 (dgcr8) antibody
  • DiGeorge syndrome critical region gene 8 (DGCR8) antibody
  • DGCR8 microprocessor complex subunit (dgcr8) antibody
  • DiGeorge syndrome critical region gene 8 (LOC100351620) antibody
  • DGCR8 microprocessor complex subunit (DGCR8) antibody
  • DiGeorge syndrome critical region gene 8 (Dgcr8) antibody
  • C22orf12 antibody
  • D16H22S788E antibody
  • D16H22S1742E antibody
  • D16Wis2 antibody
  • DGCR8 antibody
  • DGCRK6 antibody
  • Gy1 antibody
  • MGC78846 antibody
  • N41 antibody
  • pasha antibody
  • si:ch211-106a19.4 antibody
  • Vo59c07 antibody
  • wu:fc23f08 antibody
  • wu:fc38f06 antibody

Protein level used designations for DGCR8

hypothetical protein LOC432110 , DiGeorge syndrome critical region gene 8 , DiGeorge syndrome critical region 8 , microprocessor complex subunit DGCR8 , diGeorge syndrome critical region 8 homolog , DiGeorge syndrome critical region 8 homolog

GENE ID SPECIES
432110 Xenopus laevis
458659 Pan troglodytes
100144670 Xenopus (Silurana) tropicalis
100351620 Oryctolagus cuniculus
54487 Homo sapiens
94223 Mus musculus
486416 Canis lupus familiaris
100616094 Sus scrofa
540254 Bos taurus
287954 Rattus norvegicus
563963 Danio rerio
416785 Gallus gallus
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