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Results demonstrated that DGCR8 is significantly upregulated in invasive ductal breast carcinoma, suggesting that increased expression of DGCR8 may play a fundamental role during the process of breast carcinogenesis.
DGCR8 and Drosha (show DROSHA Proteins) assemble into a heterotrimeric complex on RNA, comprising two DGCR8 molecules and one Drosha (show DROSHA Proteins) molecule.
Results show that DGCR8 forms an alternative complex with the RRP6 (show EXOSC10 Proteins)-containing form of the exosome, acts as an adaptor to recruit the exosome to target structured RNAs, and the DGCR8/hRRP6 complex controls the stability of human telomerase RNA.
We aimed to evaluate the expression of the major components of microRNA biogenesis machinery including Drosha (show DROSHA Proteins), Dicer (show DICER1 Proteins) and DiGeorge syndrome critical region gene 8 (DGCR8) in multiple sclerosis patients
These results reveal a new pathway in the DNA damage response wherein ABL (show ABL1 Proteins)-dependent tyrosine phosphorylation of DGCR8 stimulates the processing of selective primary miRNAs.
DGCR8 functions as an oncogene (show RAB1A Proteins) in ovarian cancer, which is in part mediated by miR (show MLXIP Proteins)-27b.
Together with a 23-amino acid peptide from DGCR8, DROSHA (show DROSHA Proteins) constitutes a minimal functional core. DROSHA (show DROSHA Proteins) serves as a "ruler" by measuring 11 bp from the basal ssRNA-dsRNA junction. DGCR8 interacts with the stem and apical elements through its dsRNA-binding domains and RNA-binding heme domain, respectively, allowing efficient and accurate processing.
Data show decreased DGCR8 expression and miRNA dysregulation in individuals with 22q11.2 deletion syndrome
These data show that hepatitis B virus proteins repress DGCR8 promoter activity by upregulating the expression of transcription factor YY1 (show YY1 Proteins).
in tumors with DGCR8 E518K and DROSHA (show DROSHA Proteins) exon 29 (miRNAPG-HS) mutations ... greater prevalence of tumors with blastemal predominant histology in patients with miRNAPG-HS and/or SIX1 (show SIX1 Proteins)/2 Q177R mutations
DGCR8 is required for the progression, but not initiation, of Akt (show AKT1 Proteins) induced prostate cancer in vivo.
DGCR8 is required for microRNA biogenesis and normal mouse embryonic stem cell proliferation and differentiation.
Conditional gene deletion of the essential miRNA-processing enzyme Dgcr8 in the developing renal tubular system results in severe developmental defects and kidney failure.
Dgcr8 is responsible for modulation of gene expression programs underlying myelin formation and maintenance as well as suppression of an injury-related gene expression program
Dgcr8 mutant mice, which have a defective miRNA pathway while retaining an intact endo-siRNA pathway, were infertile and displayed cumulative defects in meiotic and haploid phases of spermatogenesis, resulting in oligo-, terato-, and azoospermia.
Adipose tissue-specific Dgcr8 knockout mice displayed enlarged but pale interscapular brown fat with decreased expression of genes characteristic of brown fat and were intolerant to cold exposure.
Data indicate that DiGeorge syndrome critical region gene 8 (DGCR8)-dependent miRs are indispensable for osteoclastic control of bone metabolism.
This suggests that Dgcr8-microRNA-Drd2 (show DRD2 Proteins)-dependent thalamocortical disruption is a pathogenic event underlying schizophrenia-associated psychosis.
These data reveal a role for DeltaNp63 in the transcriptional regulation of DGCR8 to reprogram adult somatic cells into multipotent stem cells.
This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants.
hypothetical protein LOC432110
, DiGeorge syndrome critical region gene 8
, DiGeorge syndrome critical region 8
, microprocessor complex subunit DGCR8
, diGeorge syndrome critical region 8 homolog
, DiGeorge syndrome critical region 8 homolog