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For mouse embryonic stem cells with induced neural differentiation, all strategies used in parallel indicate RpII to be expressed in a stable manner.
NF-Y recruits RNAPII and general transcription factors onto various CCAAT box-containing promoters to permit strong transcriptional activation independently of histone modifications
Studies indicate transcription of many genes, is regulated after the initiation step, by pausing of RNA polymerase II during elongation through the promoter-proximal region.
Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation
The highly conserved glutamic acid 791 of Rpb2 is involved in the binding of magnesium and is required for both for the polymerization and cleavage reactions.
the human Maf1 protein negatively regulates transcription by all three nuclear Pols, Pol I, Pol II and Pol III
By reducing transcriptional fidelity in terms of not only discrimination of incoming nucleotides but also recognition of templates, HDAg may facilitate the unusual RNA-dependent RNA synthesis by Pol II.
Our findings suggest that SIG-7 plays a central role in both Pol II elongation and co-transcriptional splicing and may provide an important link for their coordination and regulation
This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA.
DNA directed RNA polymerase II polypeptide B
, DNA-directed RNA polymerase II subunit RPB2
, polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
, DNA-directed RNA polymerase II subunit RPB2-like
, DNA-directed RNA polymerase II 140 kDa polypeptide
, DNA-directed RNA polymerase II subunit B
, RNA polymerase II subunit 2
, RNA polymerase II subunit B2
, DNA directed RNA polymerase II 140 kDa polypeptide, RNA polymerase II subunit 2, RNA polymerase II second largest subunit
, DNA-directed RNA polymerase II polypeptide B