Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
PACT interacts with LGP2 and this interaction is enhanced by encephalomyocarditis virus (EMCV) infection. In vitro interaction analyses using purified recombinant proteins confirmed that the single-stranded Theiler's murine encephalitis virus genome enhanced the interaction between LGP2 and PACT.
Data (including data from studies in transgenic/knockout mice) suggest that PACT/RAX (protein activator of protein kinase (show CDK7 Proteins) R) functions as negative regulator of PKR/Eif2ak2 (show EIF2AK2 Proteins) (protein kinase (show CDK7 Proteins) R) in development of postnatal anterior pituitary tissue.
Deficiency of PKR (show EIF2AK2 Proteins) diminished peripheral inflammatory responses following E. coli
The protein kinase (show CDK7 Proteins) PKR (show EIF2AK2 Proteins) is critical for LPS (show TLR4 Proteins)-induced iNOS (show NOS2 Proteins) production but is dispensable for inflammasome activation in macrophages.
These observations identified a specific mutation that reduces steady-state levels of RAX (show RAX Proteins) protein and disrupts the dsRNA binding function of the protein, demonstrating the importance of the Prkra gene in various aspects of mouse development.
RAX (show RAX Proteins) phosphorylation at serine 18 is required for PKR (show EIF2AK2 Proteins) activation and consequent translation inhibition
Study demonstrated an essential role of PACT in mammalian ear development and produced the first animal model.
The role of PACT (show RBBP6 Proteins) in mediating gene induction, PKR (show EIF2AK2 Proteins) activation, and apoptosis in response to diverse stimuli
TRBP (show TARBP2 Proteins) controls PACT (show RBBP6 Proteins) activation of PKR (show EIF2AK2 Proteins), an activity that is reversed by stress.
The authors demonstrate for the first time that PACT (show RBBP6 Proteins) is phosphorylated in response to tunicamycin and is responsible for PKR (show EIF2AK2 Proteins) activation by direct interaction.
this study shows that PACT (show RBBP6 Proteins) is an essential coactivator of the MDA5 (show IFIH1 Proteins)-dependent type I IFN response to viral RNA
High PRKRA mRNA expression is associated with colorectal cancer.
It was established in this report that interactions between PACT (show RBBP6 Proteins), ADAR1 (show ADAR Proteins) and HIV-1-encoded Tat (show TAT Proteins) protein diminish the activation of PKR (show PKLR Proteins) in response to HIV-1 infection.
5 genomic variants in GSC (show GSC Proteins), HOXA2 (show HOXA2 Proteins) and PRKRA were identified through mutational analysis in Chinese patients with microtia.
MicroRNA-122 Inhibits the Production of Inflammatory Cytokines by Targeting the PKR Activator PACT in Human Hepatic Stellate Cells.
The interferon (show IFNA Proteins)-induced protein kinase (show CDK7 Proteins)(PACT (show RBBP6 Proteins)) partially rescued defects of interferon (show IFNA Proteins)-beta1 and chemokine (C-C motif) ligand 5/RANTES (show CCL5 Proteins) (regulated on activation normal T cell expressed and secreted) induction in DDX3 (show DDX3X Proteins)-knockdown HEK293 cells.
These findings support a model in which a measles virus defective interfering RNA is sensed by PACT (show RBBP6 Proteins) and RIG-I (show DDX58 Proteins) to initiate an innate antiviral response via activation of interferon-beta (show IFNB1 Proteins) production.
this study demonstrates for the first time that OV20.0 of Orf virus is also able to interact with the dsRNA binding domain of PACT and that the presence of dsRNA strengthened the interaction of these two molecules.
the affinity of PACT-PACT and PACT-PKR interactions is enhanced in dystonia patient lymphoblasts, thereby leading to intensified PKR activation and enhanced cellular death.
Altered PRKRA signalling and C / EBPbeta expression is associated with HLA-B27 expression in monocytic cells.
Tumour necrosis factor alpha (show TNF Proteins) up-regulates protein kinase (show CDK7 Proteins) R (PKR (show EIF2AK2 Proteins))-activating protein (PACT, PRKRA) and increases phosphorylation of PKR (show EIF2AK2 Proteins) and eukaryotic initiation factor (show EIF4G1 Proteins) 2-alpha in articular chondrocytes.
This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants.
protein kinase, interferon-inducible double stranded RNA dependent activator
, interferon-inducible double stranded RNA-dependent protein kinase activator A-like
, PKR-associated protein X
, PKR-associating protein X
, interferon-inducible double stranded RNA-dependent protein kinase activator A
, protein activator of the interferon-induced protein kinase
, protein kinase, interferon-inducible double stranded RNA-dependent activator
, interferon-inducible double stranded RNA-dependent protein kinase activator A homolog
, double-stranded RNA-binding protein A
, interferon-inducible double stranded RNA-dependent protein kinase activator A homolog A
, interferon-inducible double stranded RNA-dependent protein kinase activator A homolog B