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Browse our Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator Proteins (PRKRA)

Full name:
Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator Proteins (PRKRA)
On www.antibodies-online.com are 11 Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA) Proteins from 4 different suppliers available. Additionally we are shipping Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator Antibodies (89) and many more products for this protein. A total of 110 Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator products are currently listed.
Synonyms:
AV120107, dyt16, im:7151758, lear, pact, PRK, PRKRA, prkra-a, prkra-b, rax, rbpa, zgc:162619
list all proteins Gene Name GeneID UniProt
PRKRA 23992 Q9WTX2
PRKRA 311130 Q4V8C7
PRKRA 8575 O75569

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Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator Proteins (PRKRA) by Origin

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More Proteins for Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator Interaction Partners

Mouse (Murine) Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA) interaction partners

  1. Data (including data from studies in transgenic/knockout mice) suggest that PACT/RAX (protein activator of protein kinase (show CDK7 Proteins) R) functions as negative regulator of PKR/Eif2ak2 (show EIF2AK2 Proteins) (protein kinase (show CDK7 Proteins) R) in development of postnatal anterior pituitary tissue.

  2. Deficiency of PKR (show EIF2AK2 Proteins) diminished peripheral inflammatory responses following E. coli

  3. The protein kinase (show CDK7 Proteins) PKR (show EIF2AK2 Proteins) is critical for LPS (show TLR4 Proteins)-induced iNOS (show NOS2 Proteins) production but is dispensable for inflammasome activation in macrophages.

  4. These observations identified a specific mutation that reduces steady-state levels of RAX (show RAX Proteins) protein and disrupts the dsRNA binding function of the protein, demonstrating the importance of the Prkra gene in various aspects of mouse development.

  5. RAX (show RAX Proteins) phosphorylation at serine 18 is required for PKR (show EIF2AK2 Proteins) activation and consequent translation inhibition

  6. Study demonstrated an essential role of PACT in mammalian ear development and produced the first animal model.

  7. The role of PACT (show RBBP6 Proteins) in mediating gene induction, PKR (show EIF2AK2 Proteins) activation, and apoptosis in response to diverse stimuli

  8. TRBP (show TARBP2 Proteins) controls PACT (show RBBP6 Proteins) activation of PKR (show EIF2AK2 Proteins), an activity that is reversed by stress.

  9. The authors demonstrate for the first time that PACT (show RBBP6 Proteins) is phosphorylated in response to tunicamycin and is responsible for PKR (show EIF2AK2 Proteins) activation by direct interaction.

  10. Study revealed a physiologically significant role for PACT in cell proliferation and an essential role of a dsRNA-binding protein in mammalian pituitary expansion.

Human Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA) interaction partners

  1. MicroRNA-122 Inhibits the Production of Inflammatory Cytokines by Targeting the PKR Activator PACT in Human Hepatic Stellate Cells.

  2. The interferon (show IFNA Proteins)-induced protein kinase (show CDK7 Proteins)(PACT (show RBBP6 Proteins)) partially rescued defects of interferon (show IFNA Proteins)-beta1 and chemokine (C-C motif) ligand 5/RANTES (show CCL5 Proteins) (regulated on activation normal T cell expressed and secreted) induction in DDX3 (show DDX3X Proteins)-knockdown HEK293 cells.

  3. These findings support a model in which a measles virus defective interfering RNA is sensed by PACT (show RBBP6 Proteins) and RIG-I (show DDX58 Proteins) to initiate an innate antiviral response via activation of interferon-beta (show IFNB1 Proteins) production.

  4. this study demonstrates for the first time that OV20.0 of Orf virus is also able to interact with the dsRNA binding domain of PACT and that the presence of dsRNA strengthened the interaction of these two molecules.

  5. the affinity of PACT-PACT and PACT-PKR interactions is enhanced in dystonia patient lymphoblasts, thereby leading to intensified PKR activation and enhanced cellular death.

  6. Altered PRKRA signalling and C / EBPbeta expression is associated with HLA-B27 expression in monocytic cells.

  7. This stuidy provides the first independent replication of the DYT16 locus at 2q31.2 and strongly confirms the causal contribution of the PRKRA gene to DYT16. Our data suggest worldwide involvement of PRKRA in dystonia.

  8. NS1 prevents PACT from interacting with an essential component of the virus.

  9. PKR (show PKLR Proteins) is activated in uninfected cells, specifically during mitosis, by binding to dsRNAs formed by inverted Alu repeats (IRAlus).

  10. In contrast to its previously described activity, PACT (show RBBP6 Proteins) contributes to PKR (show PKLR Proteins) dephosphorylation during HIV-1 replication.

Cow (Bovine) Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA) interaction partners

  1. Tumour necrosis factor alpha (show TNF Proteins) up-regulates protein kinase (show CDK7 Proteins) R (PKR (show EIF2AK2 Proteins))-activating protein (PACT, PRKRA) and increases phosphorylation of PKR (show EIF2AK2 Proteins) and eukaryotic initiation factor (show EIF4G1 Proteins) 2-alpha in articular chondrocytes.

Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA) Protein Profile

Protein Summary

This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA)

  • protein kinase, interferon-inducible double stranded RNA dependent activator (PRKRA)
  • protein kinase, interferon-inducible double stranded RNA dependent activator (LOC100354780)
  • protein kinase, interferon inducible double stranded RNA dependent activator (Prkra)
  • protein kinase, interferon-inducible double stranded RNA dependent activator (prkra)
  • AV120107 protein
  • dyt16 protein
  • im:7151758 protein
  • lear protein
  • pact protein
  • PRK protein
  • PRKRA protein
  • prkra-a protein
  • prkra-b protein
  • rax protein
  • rbpa protein
  • zgc:162619 protein

Protein level used designations for PRKRA

protein kinase, interferon-inducible double stranded RNA dependent activator , interferon-inducible double stranded RNA-dependent protein kinase activator A-like , PKR-associated protein X , PKR-associating protein X , interferon-inducible double stranded RNA-dependent protein kinase activator A , protein activator of the interferon-induced protein kinase , protein kinase, interferon-inducible double stranded RNA-dependent activator , interferon-inducible double stranded RNA-dependent protein kinase activator A homolog , double-stranded RNA-binding protein A , interferon-inducible double stranded RNA-dependent protein kinase activator A homolog A , interferon-inducible double stranded RNA-dependent protein kinase activator A homolog B , xlRBPA

GENE ID SPECIES
459776 Pan troglodytes
703063 Macaca mulatta
100155653 Sus scrofa
100354780 Oryctolagus cuniculus
100477392 Ailuropoda melanoleuca
100596448 Nomascus leucogenys
23992 Mus musculus
311130 Rattus norvegicus
8575 Homo sapiens
488423 Canis lupus familiaris
282875 Bos taurus
557370 Danio rerio
379187 Xenopus laevis
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