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Drx is not required for establishment of the drosophila visual system.
Deletion of Rax in the eye generated loss of central visual pathways and the suprachiasmatic nucleus was absent.
the role of Rax in the early stages of hypothalamic development
Data (including data from studies in transgenic/knockout mice) suggest that PACT/RAX (protein activator of protein kinase (show CDK7 ELISA Kits) R) functions as negative regulator of PKR/Eif2ak2 (show EIF2AK2 ELISA Kits) (protein kinase (show CDK7 ELISA Kits) R) in development of postnatal anterior pituitary tissue.
Deficiency of PKR (show EIF2AK2 ELISA Kits) diminished peripheral inflammatory responses following E. coli
Rax and Crx (show CRX ELISA Kits) cooperatively transactivate Rhodopsin (show RHO ELISA Kits) and cone opsin (show RHO ELISA Kits) promoters and an optimum Rax expression level to transactivate photoreceptor gene expression exists.
This study provided evidence that Rax is required for the normal differentiation and patterning of hypothalamic tanycytes and ependymal cells, as well as for maintenance of the cerebrospinal fluid-hypothalamus barrier.
miR (show MLXIP ELISA Kits)-29b mediated ethanol neurotoxicity through the SP1 (show SP1 ELISA Kits)/RAX/PKR (show EIF2AK2 ELISA Kits) cascade.
The protein kinase (show CDK7 ELISA Kits) PKR (show EIF2AK2 ELISA Kits) is critical for LPS (show TLR4 ELISA Kits)-induced iNOS (show NOS2 ELISA Kits) production but is dispensable for inflammasome activation in macrophages.
our study illustrates that Rax is required in ARC (show NOL3 ELISA Kits)/VMH progenitors to specify neuronal phenotypes within this hypothalamic brain region.
These observations identified a specific mutation that reduces steady-state levels of RAX protein and disrupts the dsRNA binding function of the protein, demonstrating the importance of the Prkra (show PRKRA ELISA Kits) gene in various aspects of mouse development.
The three consanguineous Egyptian anophthalmia patients carry a novel homozygous c.543+3A>G mutation (IVS2+3A>G) in RAX.
Photosensitive photoreceptor cells can be generated by combinations of transcription factors. The combination of CRX and RX generate immature photoreceptors: and additional NEUROD promotes maturation.
Mutations in the newly identified RAX regulatory sequence are not a frequent cause of micro/anophthalmia.
This gene encodes a homeobox-containing transcription factor that functions in eye development. The gene is expressed early in the eye primordia, and is required for retinal cell fate determination and also regulates stem cell proliferation. Mutations in this gene have been reported in patients with defects in ocular development, including microphthalmia, anophthalmia, and coloboma.
, drosophila Rx
, retinal homeobox
, retinal homeobox protein Rx1
, retinal homeobox protein Rx2
, retina and anterior neural fold homeobox
, PKR-associated protein X
, PKR-associating protein X
, interferon-inducible double stranded RNA-dependent protein kinase activator A
, protein activator of the interferon-induced protein kinase
, protein kinase, interferon-inducible double stranded RNA-dependent activator
, double-stranded RNA-binding protein A
, interferon-inducible double stranded RNA-dependent protein kinase activator A homolog A
, interferon-inducible double stranded RNA-dependent protein kinase activator A homolog B
, retina and anterior neural fold homeobox protein
, retinal homeobox protein Rx
, Rx/rax homeoprotein
, eyeless 1