Leukemia

Leukemia is a cancer of blood cells and the bone marrow. The name "Leukemia" derives from the greek terms for white (leukos) and blood (aima) indicating, that it is a disorder affecting the white blood cells, the leukocytes. When affected by Leukemia the leukocytes proliferate abnormally. Other cells of the plasma, such as erythrocytes (red blood cells) and thrombocytes (platelet cells) for instance are not affected. In 2000, approximately 256,000 children and adults around the world developed a form of Leukemia, and 209,000 died from it [1] .

A list of antibodies which may be useful for the ongoing research efforts improving the knowledge on Leukemia:

Name of antigen	Application	Peptide	Antibody
AHI1 / Jouberin	ELISA	-	ABIN185303
BAALC	ELISA,Western Blotting	ABIN369346	ABIN334357
ELF2 / NERF	ELISA	-	ABIN184789
FBP17 / FNBP1	ELISA,Western Blotting	-	ABIN185286
Nuleoplasmin / NPM1	Western Blotting	ABIN369612	ABIN308339
SHP2 / PTPN11	ELISA,Western Blotting	ABIN370044	ABIN184604
TRIB1	ELISA	ABIN368682	ABIN263182
BLNK / SLP-65	ELISA, Western Blotting	-	ABIN184602
BCR	ELISA, Western Blotting	-	ABIN257181
RAR-beta / RARB	Immunohistochemistry	-	ABIN258109

The progress of the disease depends on the type of Leukemia, i.e. acute or chronic Leukemia, with acute leading to a faster deterioration than chronic Leukemia. In addition, there are four different categories of Leukemia, depending on the classes of leukocytes being affected. A morphological change in leukocytes leads to an inhibition of the normal function in the defense against infections. Hence Leukemia patients often experience an increased prevalence of infections and fevers, besides other symptoms.

These other symptoms partially derive from an imbalance of the other blood cells, like erythrocytes and platelets, leading to a lack of oxygen and a disturbance in the clotting reaction. Other symptoms can include weight loss, swollen lymph nodes, flu-like symptoms, fatigue, enlarged spleen and liver, pain in bones and joints, and many more. The causes of Leukemia, whether genetic or environmental, are poorly understood, complicating the development of prevention programs or efficient treatment regimens.

Hint: On antibodies-online.com you will find more than 2.400 antibodies for cancer research.