Browse our anti-Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3) Antibodies

On www.antibodies-online.com are 115 Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3) Antibodies from 24 different suppliers available. Additionally we are shipping Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) Proteins (14) and Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) Kits (4) and many more products for this protein. A total of 140 Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) products are currently listed.
Synonyms:
AKR1C3, Akr1c18, DD3, DDX, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5, MGC134333, PGFS
list all antibodies Gene Name GeneID UniProt
AKR1C3 8644 P42330
AKR1C3 171516 P51652
AKR1C3    

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More Antibodies against Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) Interaction Partners

Human Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3) interaction partners

  1. Data suggest that, in breast cancer cells, expression of HSD17B5 and expression of GRP78 (show HSPA5 Antibodies) (an apoptosis inhibitor) are strongly but negatively correlated; GRP78 (show HSPA5 Antibodies) knockdown decreases breast cancer cell viability whereas HSD17B5 knockdown increases cell viability and cell proliferation. (HSD17B5, 17-beta-hydroxysteroid dehydrogenase 5; GRP78 (show HSPA5 Antibodies), 78 kDa glucose-regulated protein (show HSPA5 Antibodies))

  2. AKR1C3 is the primary enzyme and CBR1 (show CBR1 Antibodies) is a minor enzyme responsible for warfarin reduction in human liver cytosol.

  3. the present study suggests that AKR1C1 (show DDH Antibodies), AKR1C2 (show AKR1C2 Antibodies), AKR1C3, and AKR1C4 (show AKR1C4 Antibodies) are closely associated with drug resistance to both CDDP and 5FU, and that mefenamic acid, an inhibitor of AKR1C, restores sensitivity through inhibition of drug-resistance in human cancer cells.

  4. a variant in the promoter region of HSD17B5 related to fetal androgen synthesis influences the genital phenotype in 21-Hydroxylase Deficiency females.

  5. Five common AKR1C3 polymorphisms were associated with decreased rates of exemestane catalysis.

  6. If our these findings can be reproduced in larger homogeneous cohorts, a genetic stratification based on the AKR1C3 rs12529 single nucleotide polymorphism, can minimize androgen deprivation therapy-related health-related quality of life effects in prostate cancer patients

  7. We identified strong associations between the studied AKR1C3 variants and UBC (show RPS27A Antibodies) risk. The homozygous variant genotype of rs12529 was found to be inversely associated with UBC (show RPS27A Antibodies), and rs1937920 was shown to be associated with increased risk of UBC (show RPS27A Antibodies). None of the genotypes were found to be significantly associated with tumor characteristics.

  8. aldo-keto reductase 1C3-mediated prostaglandin D2 metabolism has a role in keloids

  9. The results suggest that decreased expression of AKR1C3 may be involved in development of gastric cancer and can be restored by Sodium Butyrate.

  10. AKR1C3 expression is elevated in prostate cancer cell lines and primary prostate cancer, suggesting a link between AKR1C3 levels and the epigenetic status in prostate cancer cells.

Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3) Antigen Profile

Antigen Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3)

  • aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (akr1c3) antibody
  • aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (AKR1C3) antibody
  • aldo-keto reductase family 1, member C3 (AKR1C3) antibody
  • aldo-keto reductase family 1, member C3 (Akr1c3) antibody
  • AKR1C3 antibody
  • Akr1c18 antibody
  • DD3 antibody
  • DDX antibody
  • HA1753 antibody
  • HAKRB antibody
  • HAKRe antibody
  • hluPGFS antibody
  • HSD17B5 antibody
  • MGC134333 antibody
  • PGFS antibody

Protein level used designations for AKR1C3

aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) , prostaglandin F synthase , aldo-keto reductase family 1 member C3 homolog , 3-alpha hydroxysteroid dehydrogenase, type II , 3-alpha-HSD type II, brain , aldo-keto reductase family 1 member C3 , chlordecone reductase homolog HAKRb , dihydrodiol dehydrogenase 3 , dihydrodiol dehydrogenase X , indanol dehydrogenase , testosterone 17-beta-dehydrogenase 5 , trans-1,2-dihydrobenzene-1,2-diol dehydrogenase , type IIb 3-alpha hydroxysteroid dehydrogenase , 20 alpha-hydroxysteroid dehydrogenase , 20-alpha-HSD , 20-alpha-hydroxysteroid dehydrogenase , 20alpha-hydroxysteroid dehydrogenase , HSD1 , aldo-keto reductase family 1 member C18 , aldo-keto reductase family 1, member C18 , 17-beta-HSD 5 , 17-beta-hydroxysteroid dehydrogenase type 5 , 3-alpha-HSD type 2 , 3-alpha-hydroxysteroid dehydrogenase type 2 , PGFS

GENE ID SPECIES
443571 Xenopus laevis
497070 Canis lupus familiaris
617917 Bos taurus
722496 Macaca mulatta
100510801 Felis catus
100612718 Pan troglodytes
8644 Homo sapiens
171516 Rattus norvegicus
100174617 Pongo abelii
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