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Browse our Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) Proteins (AKR1C3)

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Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) Proteins (AKR1C3)
On www.antibodies-online.com are 13 Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3) Proteins from 9 different suppliers available. Additionally we are shipping Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) Antibodies (111) and Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) Kits (3) and many more products for this protein. A total of 134 Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) products are currently listed.
Synonyms:
AKR1C3, Akr1c18, DD3, DDX, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5, MGC134333, PGFS
list all proteins Gene Name GeneID UniProt
AKR1C3 8644 P42330
Rat AKR1C3 AKR1C3 171516 P51652
AKR1C3    

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Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) Proteins (AKR1C3) by Origin

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Top referenced Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) Proteins

  1. Human AKR1C3 Protein expressed in Escherichia coli (E. coli) - ABIN666747 : Davies, Hayden, Simpson, Birtwistle, Mayer, Ride, Bunce: AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. in Cancer research 2009 (PubMed)
    Show all 2 references for ABIN666747

More Proteins for Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) Interaction Partners

Human Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3) interaction partners

  1. AKR1C3 is the primary enzyme and CBR1 (show CBR1 Proteins) is a minor enzyme responsible for warfarin reduction in human liver cytosol.

  2. the present study suggests that AKR1C1 (show DDH Proteins), AKR1C2 (show AKR1C2 Proteins), AKR1C3, and AKR1C4 (show AKR1C4 Proteins) are closely associated with drug resistance to both CDDP and 5FU, and that mefenamic acid, an inhibitor of AKR1C, restores sensitivity through inhibition of drug-resistance in human cancer cells.

  3. a variant in the promoter region of HSD17B5 related to fetal androgen synthesis influences the genital phenotype in 21-Hydroxylase Deficiency females.

  4. Five common AKR1C3 polymorphisms were associated with decreased rates of exemestane catalysis.

  5. If our these findings can be reproduced in larger homogeneous cohorts, a genetic stratification based on the AKR1C3 rs12529 single nucleotide polymorphism, can minimize androgen deprivation therapy-related health-related quality of life effects in prostate cancer patients

  6. We identified strong associations between the studied AKR1C3 variants and UBC (show RPS27A Proteins) risk. The homozygous variant genotype of rs12529 was found to be inversely associated with UBC (show RPS27A Proteins), and rs1937920 was shown to be associated with increased risk of UBC (show RPS27A Proteins). None of the genotypes were found to be significantly associated with tumor characteristics.

  7. aldo-keto reductase 1C3-mediated prostaglandin D2 metabolism has a role in keloids

  8. The results suggest that decreased expression of AKR1C3 may be involved in development of gastric cancer and can be restored by Sodium Butyrate.

  9. AKR1C3 expression is elevated in prostate cancer cell lines and primary prostate cancer, suggesting a link between AKR1C3 levels and the epigenetic status in prostate cancer cells.

  10. Aldo-keto reductase 1C3 is overexpressed in skin squamous cell carcinoma (SCC (show CYP11A1 Proteins)). AKR1C3 affects SCC (show CYP11A1 Proteins) growth via prostaglandin metabolism.

Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3) Protein Profile

Protein Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3)

  • aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (akr1c3)
  • aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (AKR1C3)
  • aldo-keto reductase family 1, member C3 (AKR1C3)
  • aldo-keto reductase family 1, member C3 (Akr1c3)
  • AKR1C3 protein
  • Akr1c18 protein
  • DD3 protein
  • DDX protein
  • HA1753 protein
  • HAKRB protein
  • HAKRe protein
  • hluPGFS protein
  • HSD17B5 protein
  • MGC134333 protein
  • PGFS protein

Protein level used designations for AKR1C3

aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) , prostaglandin F synthase , aldo-keto reductase family 1 member C3 homolog , 3-alpha hydroxysteroid dehydrogenase, type II , 3-alpha-HSD type II, brain , aldo-keto reductase family 1 member C3 , chlordecone reductase homolog HAKRb , dihydrodiol dehydrogenase 3 , dihydrodiol dehydrogenase X , indanol dehydrogenase , testosterone 17-beta-dehydrogenase 5 , trans-1,2-dihydrobenzene-1,2-diol dehydrogenase , type IIb 3-alpha hydroxysteroid dehydrogenase , 20 alpha-hydroxysteroid dehydrogenase , 20-alpha-HSD , 20-alpha-hydroxysteroid dehydrogenase , 20alpha-hydroxysteroid dehydrogenase , HSD1 , aldo-keto reductase family 1 member C18 , aldo-keto reductase family 1, member C18 , 17-beta-HSD 5 , 17-beta-hydroxysteroid dehydrogenase type 5 , 3-alpha-HSD type 2 , 3-alpha-hydroxysteroid dehydrogenase type 2 , PGFS

GENE ID SPECIES
443571 Xenopus laevis
497070 Canis lupus familiaris
617917 Bos taurus
722496 Macaca mulatta
100510801 Felis catus
100612718 Pan troglodytes
8644 Homo sapiens
171516 Rattus norvegicus
100174617 Pongo abelii
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