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Browse our Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) Proteins (AKR1C3)

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Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) Proteins (AKR1C3)
On www.antibodies-online.com are 12 Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3) Proteins from 8 different suppliers available. Additionally we are shipping Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) Antibodies (106) and Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) Kits (11) and many more products for this protein. A total of 137 Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) products are currently listed.
Synonyms:
AKR1C3, Akr1c18, DD3, DDX, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5, MGC134333, PGFS
list all proteins Gene Name GeneID UniProt
AKR1C3 8644 P42330
Rat AKR1C3 AKR1C3 171516 P51652
AKR1C3    

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Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) Proteins (AKR1C3) by Origin

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Top referenced Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) Proteins

  1. Human AKR1C3 Protein expressed in Escherichia coli (E. coli) - ABIN666747 : Davies, Hayden, Simpson, Birtwistle, Mayer, Ride, Bunce: AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. in Cancer research 2009 (PubMed)
    Show all 2 references for ABIN666747

More Proteins for Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) Interaction Partners

Human Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3) interaction partners

  1. AKR1C3 expression is elevated in prostate cancer cell lines and primary prostate cancer, suggesting a link between AKR1C3 levels and the epigenetic status in prostate cancer cells.

  2. Aldo-keto reductase 1C3 is overexpressed in skin squamous cell carcinoma (SCC (show CYP11A1 Proteins)). AKR1C3 affects SCC (show CYP11A1 Proteins) growth via prostaglandin metabolism.

  3. these results indicated that the actions of AKR1C3 can produce FP receptor (show PTGFR Proteins) ligands whose activation results in carcinoma cell survival in breast cancer.

  4. and AKR1C3 may serve as a valuable therapeutic target in the treatment of castration-resistant prostate cancer

  5. AKR1C3 activation is a critical resistance mechanism associated with enzalutamide resistance.

  6. In the present study, crystal structures of complexes of HSD17B5 with structurally diverse inhibitors derived from high-throughput screening were determined.

  7. AKR1C3 mRNA expression did not differ between bipolar disorder patients in any affective state or in comparison with healthy control subjects.

  8. A catalysis-independent role for AKR1C3 on AR activity via Siah2 (show SIAH2 Proteins) has been identified.

  9. AKR1C3 mediated doxorubicin resistance might be resulted from the activation of anti-apoptosis PTEN/Akt pathway via PTEN loss.

  10. Findings indicate the potential involvement of aldo-keto reductase AKR1C3 in the acquired radioresistance by AKR1C3 overexpression.

Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3) Protein Profile

Protein Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3)

  • aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (akr1c3)
  • aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (AKR1C3)
  • aldo-keto reductase family 1, member C3 (AKR1C3)
  • aldo-keto reductase family 1, member C3 (Akr1c3)
  • AKR1C3 protein
  • Akr1c18 protein
  • DD3 protein
  • DDX protein
  • HA1753 protein
  • HAKRB protein
  • HAKRe protein
  • hluPGFS protein
  • HSD17B5 protein
  • MGC134333 protein
  • PGFS protein

Protein level used designations for AKR1C3

aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) , prostaglandin F synthase , aldo-keto reductase family 1 member C3 homolog , 3-alpha hydroxysteroid dehydrogenase, type II , 3-alpha-HSD type II, brain , aldo-keto reductase family 1 member C3 , chlordecone reductase homolog HAKRb , dihydrodiol dehydrogenase 3 , dihydrodiol dehydrogenase X , indanol dehydrogenase , testosterone 17-beta-dehydrogenase 5 , trans-1,2-dihydrobenzene-1,2-diol dehydrogenase , type IIb 3-alpha hydroxysteroid dehydrogenase , 20 alpha-hydroxysteroid dehydrogenase , 20-alpha-HSD , 20-alpha-hydroxysteroid dehydrogenase , 20alpha-hydroxysteroid dehydrogenase , HSD1 , aldo-keto reductase family 1 member C18 , aldo-keto reductase family 1, member C18 , 17-beta-HSD 5 , 17-beta-hydroxysteroid dehydrogenase type 5 , 3-alpha-HSD type 2 , 3-alpha-hydroxysteroid dehydrogenase type 2 , PGFS

GENE ID SPECIES
443571 Xenopus laevis
497070 Canis lupus familiaris
617917 Bos taurus
722496 Macaca mulatta
100510801 Felis catus
100612718 Pan troglodytes
8644 Homo sapiens
171516 Rattus norvegicus
100174617 Pongo abelii
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