Browse our Aldehyde Dehydrogenase 1 Family, Member A2 Proteins (ALDH1A2)

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Aldehyde Dehydrogenase 1 Family, Member A2 Proteins (ALDH1A2)
On are 8 Aldehyde Dehydrogenase 1 Family, Member A2 (ALDH1A2) Proteins from 5 different suppliers available. Additionally we are shipping Aldehyde Dehydrogenase 1 Family, Member A2 Antibodies (76) and Aldehyde Dehydrogenase 1 Family, Member A2 Kits (4) and many more products for this protein. A total of 93 Aldehyde Dehydrogenase 1 Family, Member A2 products are currently listed.
Aldh1a7, AV116159, fb50h01, RALDH(II), Raldh-2, Raldh1, Raldh2, RALDH2-T
list all proteins Gene Name GeneID UniProt
ALDH1A2 116676 Q63639
ALDH1A2 8854 O94788
ALDH1A2 19378 Q62148

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Human Aldehyde Dehydrogenase 1 Family, Member A2 (ALDH1A2) interaction partners

  1. Data show that hRALDH2 is not inhibited by its oxidation product, all-trans-RA, suggesting the absence of a negative feedback regulatory loop. Expression of the Raldh2 gene is known to be regulated by RA itself, suggesting that the main regulation of the hRALDH2 activity level is transcriptional.

  2. Study shows no evidence that genetic variants alter prostate cancer incidence, but show that SNPs in the ALDH1A2 gene affect prostate cancer mortality.

  3. a critical role of ALDH1A2-RAR (show RARA Proteins) signaling in the pathogenesis of head and neck cancer.

  4. High expression of ALDH1A2 and ALDH1B1 (show ALDH1B1 Proteins) mRNA was found to be significantly correlated to worser survival in all NSCLC patients.

  5. the distribution of RALDH1 (show ALDH1A1 Proteins), RALDH2, and RALDH3 (show ALDH1A3 Proteins) in the postnatal eye was determined.

  6. ALDH1A2 is involved in the regulation of cancer stem cell properties in neuroblastoma (show ARHGEF16 Proteins).

  7. Genetic association replicative and exploratory studies identify SNPs in ADA (show ADA Proteins) and MTR (show MTR Proteins) highly associated with isolated Neural tube defects (NTD)and SNP in ARID1A and ALDH1A2 associated with NTDs in whites and African Americans respectively.

  8. At the transcript level, the cisplatin + DEAB-resistant cells showed upregulated mRNA expression levels for ALDH1A2, ALDH1A3 (show ALDH1A3 Proteins) isozymes and CD44 (show CD44 Proteins) indicating the involvement of these markers in conferring chemoresistance

  9. DNA methylation (show HELLS Proteins) at multiple CpG sites is associated with loss of control over alcohol drinking.

  10. Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.

Zebrafish Aldehyde Dehydrogenase 1 Family, Member A2 (ALDH1A2) interaction partners

  1. Zebrafish foxc1a plays a crucial role in early somitogenesis by restricting the expression of Raldh2 directly.

  2. The novel aldh1a2 reporter line is driven by the complete set of regulatory sequences required for zebrafish development, reports novel sources of RA synthesis, and identifies the source of RA that promotes vertebral ossification.

  3. aldh1a2 participate to a positive loop required for branchial arches development in zebrafish

  4. Aldh1a2 is the primary aldehyde dehydrogenase acting during pancreas development and maternal Aldh1a2 activity persists in aldh1a2(um22) and aldh1a2(i26) mutant embryos.

  5. Studies indicate that raldh2 expression is critical for the formation of wound epithelium and blastema.

Mouse (Murine) Aldehyde Dehydrogenase 1 Family, Member A2 (ALDH1A2) interaction partners

  1. ALDH2 (show ALDH2 Proteins) mutation displays an inverse correlation of coronary collateral vessel formation in patients.

  2. Data suggest that retinoic acid and GM-CSF (show CSF2 Proteins)-induced retinal dehydrogenase 2 (RALDH2) expression in dendritic cells requires cooperative binding of transcription factor Sp1 (show SP1 Proteins) via the RA receptor/retinoid X receptor (show RXRB Proteins) complex to the Aldh1a2 (show ALDH1A1 Proteins) promoter.

  3. all three proteins (RDH10 (show RDH10 Proteins), RALDH2, and CRABP2 (show CRABP2 Proteins)) appeared to be required for ATRA production induced by activation of PPARgamma (show PPARG Proteins)

  4. Defects in interdigital programmed cell death and digit separation in Hoxa13 (show HOXA13 Proteins) mutant mice may be caused in part by reduced levels of RA signaling stemming from a loss in the direct regulation of Aldh1a2 (show ALDH1A1 Proteins)

  5. Raldh1 (show ALDH1A1 Proteins) and Raldh3 (show ALDH1A3 Proteins) influence enteric nervous system structure and function and heterozygosity for Raldh2 causes ENS defects

  6. ALDH1A2 expression was highest in ALDH(very-br) cells, intermediate in ALDH(dim) cells, and lowest in ALDH(br) cells.

  7. Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice.

  8. rendered Fgfr2IIIb (show FGFR2 Proteins)(-/-) embryos haploinsufficient for the Raldh2 and examined these embryos for the incidence and severity of duodenal atresia

  9. Expression of ALDH1A2 (show ALDH1A1 Proteins), BEX2 (show BEX2 Proteins), EGR2 (show EGR2 Proteins), CCL3 (show CCL3 Proteins) and PLAU (show PLAU Proteins) are upregulated in Toxoplasma gondiisusceptible C57BL/6 mice.

  10. RA via RALDH2 has separable functions in the developing spinal cord to (i) maintain high levels of FGF and Notch (show NOTCH1 Proteins) signaling and (ii) drive stem cell differentiation, thus restricting both the numbers and the pluripotent character of neural stem cells

Aldehyde Dehydrogenase 1 Family, Member A2 (ALDH1A2) Protein Profile

Protein Summary

This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene.

Alternative names and synonyms associated with Aldehyde Dehydrogenase 1 Family, Member A2 (ALDH1A2)

  • aldehyde dehydrogenase 1 family, member A2 (Aldh1a2)
  • aldehyde dehydrogenase 1 family, member A2 (ALDH1A2)
  • aldehyde dehydrogenase 1 family, member A2 (aldh1a2)
  • aldehyde dehydrogenase family 1, subfamily A2 (Aldh1a2)
  • Aldh1a7 protein
  • AV116159 protein
  • fb50h01 protein
  • RALDH(II) protein
  • Raldh-2 protein
  • Raldh1 protein
  • Raldh2 protein
  • RALDH2-T protein

Protein level used designations for ALDH1A2

RALDH 2 , RalDH(II) , aldehyde dehydrogenase 1A2 , aldehyde dehydrogenase family 1 member A2 , aldehyde dehydrogenase family 1, subfamily A2 , ralDH2 , retinal dehydrogenase 2 , retinal dehydrogenase, type II , retinaldehyde-specific dehydrogenase type 2 , neckless , nls , no-fin , nof , retinaldehyde dehydrogenase 2 , RALDH(II) , alcohol dehydrogenase family 1, subfamily A2 , alcohol dehydrogenase family 1, subfamily A7

116676 Rattus norvegicus
8854 Homo sapiens
116713 Danio rerio
395844 Gallus gallus
478319 Canis lupus familiaris
535075 Bos taurus
19378 Mus musculus
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