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Browse our ASXL1 Proteins (ASXL1)

Full name:
Additional Sex Combs Like 1 (Drosophila) Proteins (ASXL1)
On www.antibodies-online.com are 5 Additional Sex Combs Like 1 (Drosophila) (ASXL1) Proteins from 3 different suppliers available. Additionally we are shipping ASXL1 Antibodies (34) and many more products for this protein. A total of 40 ASXL1 products are currently listed.
Synonyms:
asxl1, BOPS, MDS, MGC83850, mKIAA0978
list all proteins Gene Name GeneID UniProt
ASXL1 228790 P59598
ASXL1 171023 Q8IXJ9

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ASXL1 Proteins (ASXL1) by Origin

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More Proteins for ASXL1 Interaction Partners

Mouse (Murine) Additional Sex Combs Like 1 (Drosophila) (ASXL1) interaction partners

  1. implicate Asxl1 in the maintenance of podocyte structure via its association with Wtip (show WTIP Proteins) and in the regulation of WT1 (show WT1 Proteins) signaling during early kidney development

  2. ASXL1 truncation mutations confer gain-of-function on the ASXL-BAP1 (show BAP1 Proteins) complex.

  3. Asxl1-/- fetuses have reduced body weight and display cleft palate, anophthalmia as well as ventricular septal defects and a failure in lung maturation.

  4. Asxl1 functions as a tumor suppressor to maintain hematopoietic cell homeostasis

  5. C-terminal-truncating Asxl1 mutations inhibited myeloid differentiation and induced myelodysplastic syndrome-like disease

  6. Constitutive loss of Asxl1 results in developmental abnormalities, including anophthalmia, microcephaly, cleft palate, and mandibular malformations. Hematopoietic-specific deletion results in cytopenia and dysplasia with increased hematopoietic stem cells

  7. ASXL1 represses, whereas ASXL2 increases, the expression of adipogenic genes, most of which are PPARgamma (show PPARG Proteins) targets

  8. Asxl1 is needed for normal hematopoiesis.

  9. Asxl1and Asxl2 are expressed as multiple transcripts, at varying levels, in adult tissues and in embryonic stem cells analyzed by Northern blot, and exhibit similar expression patterns suggesting they may be co-regulated

  10. ASXL1 is a novel coactivator of RAR (show RARA Proteins) that cooperates with SRC-1 (show NCOA1 Proteins)

Human Additional Sex Combs Like 1 (Drosophila) (ASXL1) interaction partners

  1. We examined all ASXL1 truncating variants in the ExAC database and determined most are likely somatic. Failure to consider somatic mosaicism may lead to the inaccurate assumption that conditions like BOS have reduced penetrance, or the misclassification of potentially pathogenic variants.

  2. ASXL1 Circular RNA is Produced by Splicing from its pre-mRNA.

  3. We conclude that ASXL1 is essential for erythroid development and differentiation and that the aberrant differentiation is, at least in part, facilitated via PRC2.

  4. Demonstration of ASXL1 mutation, a putative tumor suppressor gene, represents an important molecular abnormality in CML (show BCR Proteins). Authors also showed that concomitant detection of BCR-ABL (show ABL1 Proteins) and JAK2V617F mutations has a relatively high incidence in Iranian patients.

  5. This study showed ASXL1 exon 12 mutations in 16 of 70 (23%) patients with myelofibrosis, with 11 different mutations found in these patients.

  6. Mutations in ASXL1, U2AF1 (show U2AF1 Proteins), and SF3B1 (show SF3B2 Proteins) are common in Chinese patients with myelodysplastic syndromes.

  7. ASXL1 germline missense substitution is associated with hematological malignancies.

  8. identified significant ASXL1 SNPs in Chinese patients with acquired aplastic anemia (AA); results showed 8.2% had the recurrent conjoined rs62206933, rs117901891 and rs74638057 genotype (WT1 (show WT1 Proteins)), which was closely associated with poor prognosis in patients with nonsevere AA and had a greater risk of transformation to myelodysplastic syndrome

  9. Correction of ASXL1 driver mutation in leukemia cells using CRISPR/Cas (show CSE1L Proteins) increases survival in vivo in mice.

  10. We confirm the negative prognostic impact imparted by ASXL1 mutations and suggest a favorable impact from TET2 mutations in the absence of ASXL1 mutations.

ASXL1 Protein Profile

Protein Summary

This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with ASXL1

  • additional sex combs like 1 (Drosophila) (asxl1)
  • additional sex combs like 1 (LOC100341931)
  • additional sex combs like 1 (asxl1)
  • additional sex combs like 1 (Asxl1)
  • additional sex combs like 1 (Drosophila) (ASXL1)
  • asxl1 protein
  • BOPS protein
  • MDS protein
  • MGC83850 protein
  • mKIAA0978 protein

Protein level used designations for ASXL1

additional sex combs like 1 , additional sex combs-like protein 1 , putative Polycomb group protein ASXL1

GENE ID SPECIES
446414 Xenopus laevis
100341931 Oryctolagus cuniculus
100379981 Xenopus (Silurana) tropicalis
228790 Mus musculus
171023 Homo sapiens
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