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Single nucleotide polymorphism in CNOT1 gene is associated with osteosarcoma susceptibility.
CNOT1 facilitates recruitment of DDX6 (show DDX6 ELISA Kits) to miRNA-targeted mRNAs, placing DDX6 (show DDX6 ELISA Kits) as a downstream effector in the miRNA silencing pathway.
Crystal structures of the DDX6 (show DDX6 ELISA Kits), CNOT1 and CNOT9 (show RQCD1 ELISA Kits) complexes.
Crystal structure of the DDX6 (show DDX6 ELISA Kits), CNOT9 (show RQCD1 ELISA Kits) and CNOT1 complex.
The CNOT2 (show CNOT2 ELISA Kits)-CNOT3 (show CNOT3 ELISA Kits) heterodimer is stabilized and tightly anchored to the surface of CNOT1 through an unexpected intertwined arrangement of peptide regions lacking defined secondary structure.
Authors identify an evolutionarily conserved C-terminal motif in human TTP (show ADAMTS13 ELISA Kits) that directly binds a central domain of CNOT1, a core subunit of the CCR4 (show CCR4 ELISA Kits)-NOT complex.
The NOT1 MIF4G domain binds CAF1 through a pre-formed interface and leaves the CAF1 catalytic site fully accessible to RNA substrates.
Cnot1, Cnot2 (show CNOT2 ELISA Kits), and Cnot3 (show CNOT3 ELISA Kits) represent a novel component of the core self-renewal and pluripotency circuitry conserved in mouse and human ESCs (show NR2E3 ELISA Kits).
Depletion of CNOT1 induces cell death in a caspase (show CASP3 ELISA Kits)-dependent manner.
purification and characterization of 1.0 MDa yeast CCR4 (show CCR4 ELISA Kits)-NOT complex identifies two novel components, CAF40 and CAF130: yeast CAF40 binds human NOT1
Collectively, our data support a model of CNOT7 (show CNOT7 ELISA Kits), TOB1, CNOT1, and RNA-binding proteins collectively exerting post-transcriptional control on a metastasis suppressive transcriptional program to drive tumor cell metastasis
These data have uncovered a novel role of core components of the Ccr4 (show CCR4 ELISA Kits)-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells.
Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors (By similarity).
CCR4-NOT transcription complex subunit 1
, adrenal gland protein AD-005
, CCR4-NOT transcription complex, subunit 1
, CCR4-associated factor 1
, CCR4-NOT transcription complex subunit 1-like
, NOT1 (negative regulator of transcription 1, yeast) homolog
, negative regulator of transcription subunit 1 homolog