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Browse our CREM Proteins (CREM)

Full name:
CAMP Responsive Element Modulator Proteins (CREM)
On www.antibodies-online.com are 8 CAMP Responsive Element Modulator (CREM) Proteins from 4 different suppliers available. Additionally we are shipping CREM Antibodies (92) and CREM Kits (6) and many more products for this protein. A total of 120 CREM products are currently listed.
Synonyms:
CREM, CREM-2, hCREM-2, Icer, ICERI
list all proteins Gene Name GeneID UniProt
CREM 1390 Q03060
CREM 12916 P27699
Rat CREM CREM 25620 Q03061

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CREM Proteins (CREM) by Origin

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More Proteins for CREM Interaction Partners

Human CAMP Responsive Element Modulator (CREM) interaction partners

  1. These findings indicated that the polymorphisms of CREM gene were associated with nonobstructive azoospermia in the Chinese population and low CREM expression might be involved in the pathogenesis of spermatogenesis maturation arrest.

  2. In Alzheimer's brain, we found an increased cellular expression of CREM in dentate gyrus neurons as compared to normal aging brains.

  3. Data suggest ICER/CREM plays seminal role in down-regulation of expression/secretion of insulin (show INS Proteins) by pancreatic beta-cell as an adaptive response to factors that promote diabetes; inappropriate induction of ICER leads to beta-cell dysfunction. [REVIEW]

  4. CaMK4 (show CAMK4 Proteins)-dependent activation of AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) and CREM-alpha underlies autoimmunity-associated Th17 imbalance.

  5. CREMalpha orchestrates epigenetic remodeling of the CD8A (show CD8A Proteins),B through the recruitment of DNA methyltransferase (show DNMT1 Proteins) (DNMT (show DNMT1 Proteins)) 3a and histone methyltransferase G9a (show EHMT2 Proteins).

  6. Data suggest that cyclic AMP (show APRT Proteins) response element modulator-1 (CREM-1) might play an important role in the regulation of tumor metastasis and invasion and serve as a tumor suppressor in esophageal squamous cell carcinoma (ESCC).

  7. Transcription factor CREM is an important regulator of atrial growth implicated in the development of atrial fibrillation.

  8. transcription factor cAMP-responsive element modulator alpha (CREMalpha), which is expressed at increased levels in T cells from systemic lupus erythematosus patients, contributes to transcriptional silencing of CD8A (show CD8A Proteins) and CD8B (show CD8B Proteins).

  9. The results of this study suggested that the single nucleotide polymorphisms of CREM do not influence diagnosis and treatment response in patients with major depressive disorder and bipolar disorder.

  10. Increased CREMalpha binding to the Notch-1 (show NOTCH1 Proteins) promoter resulted in significantly reduced Notch-1 (show NOTCH1 Proteins) promoter activity and gene transcription.

Cow (Bovine) CAMP Responsive Element Modulator (CREM) interaction partners

  1. results are consistent with the suggestions that cAMP responsive element modulator variants are involved in spermiogenesis in the testes of Japanese Black bulls

Mouse (Murine) CAMP Responsive Element Modulator (CREM) interaction partners

  1. Crem(-/-) mice exhibited increased proliferation of primary aortic VSMCs along with upregulation of PDGF (show PDGFA Proteins) signaling.

  2. These data identify ICER as a redundant mediator of Treg cells and cAMP action on Teff cells and suggest that Epac (show RAPGEF3 Proteins) may function as an alternative effector to promote cAMP-dependent Teff cell suppression.

  3. CaMK4 (show CAMK4 Proteins)-dependent activation of AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) and CREM-alpha underlies autoimmunity-associated Th17 imbalance.

  4. CREMalpha orchestrates epigenetic remodeling of the CD8A (show CD8A Proteins),B through the recruitment of DNA methyltransferase (show DNMT1 Proteins) (DNMT (show DNMT1 Proteins)) 3a and histone methyltransferase G9a (show EHMT2 Proteins).

  5. levels of CREM in T cells determine the outcome of acute lung injury, and CREMalpha transgenic animals represent a model in which proinflammatory T cells aggravate acute lung injury in different phases of the disease.

  6. Reduction of connexin36 (show GJD2 Proteins) content by ICER-1 contributes to insulin (show INS Proteins)-secreting cells apoptosis induced by oxidized LDL particles.

  7. Inducible cAMP early repressor regulates the Period 1 gene of the hepatic and adrenal clocks.

  8. Data suggest that expression of TRH (thyrotropin-releasing hormone (show TRH Proteins)) is up-regulated by CREM in hypothalamus; however, regulation of TRH (show TRH Proteins) by triiodothyronine appears independent of expression of CREM or CREB (cAMP responsive element binding protein (show CREB1 Proteins)).

  9. analysis of insights into the downstream pathways and targets controlled by transcription factors CREM in the testis

  10. CREMalpha overexpression decreases IL-2 (show IL2 Proteins) production, induces a T(H)17 phenotype and accelerates autoimmunity.

Pig (Porcine) CAMP Responsive Element Modulator (CREM) interaction partners

  1. This study is apparently the first report demonstrating the expression and localization of the activator CREM isoform ortholog proteins in spermatids and ejaculated sperm of a livestock species.

  2. In contrast to the adult cyclic AMP (show TMPRSS5 Proteins) responsive element modulator(CREM) isoforms, only CREM messenger RNA isoforms with the B exon were amplified in the immature boar testes

  3. Spermatozoa isolated from semen samples of boars contained all transcripts investigated, whereas oocytes contained only CREM, H1, TAF1 (show TAF1 Proteins), and TBP (show TBP Proteins) mRNAs.

CREM Protein Profile

Protein Summary

This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.

Alternative names and synonyms associated with CREM

  • cAMP responsive element modulator (CREM)
  • cAMP responsive element modulator (Crem)
  • CREM protein
  • CREM-2 protein
  • hCREM-2 protein
  • Icer protein
  • ICERI protein

Protein level used designations for CREM

cAMP responsive element modulator , cAMP response element modulator tau , ICER protein , cAMP-responsive element modulator , CREM 2alpha-b protein , CREM 2beta-a protein , cAMP response element modulator , inducible cAMP early repressor ICER , cAMP responsive element moderator , cAMP-responsive element moderator , CRE modulator , inducible cyclic AMP early repressor

GENE ID SPECIES
100054937 Equus caballus
450400 Pan troglodytes
100125358 Ovis aries
698636 Macaca mulatta
378903 Gallus gallus
1390 Homo sapiens
403887 Canis lupus familiaris
540605 Bos taurus
12916 Mus musculus
25620 Rattus norvegicus
448969 Sus scrofa
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