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Browse our CYP26A1 Proteins (CYP26A1)

Full name:
Cytochrome P450, Family 26, Subfamily A, Polypeptide 1 Proteins (CYP26A1)
On are 8 Cytochrome P450, Family 26, Subfamily A, Polypeptide 1 (CYP26A1) Proteins from 5 different suppliers available. Additionally we are shipping CYP26A1 Antibodies (75) and CYP26A1 Kits (18) and many more products for this protein. A total of 109 CYP26A1 products are currently listed.
cb24, CP26, Cyp26, CYP26A, id:ibd5061, P450RA, P450RAI, P450RAI1, RACE, RAH, wu:fb81e05, xCYP26, XCYP26A1
list all proteins Gene Name GeneID UniProt
CYP26A1 1592 O43174
CYP26A1 13082 O55127
Rat CYP26A1 CYP26A1 154985  

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CYP26A1 Proteins (CYP26A1) by Origin

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More Proteins for CYP26A1 Interaction Partners

Xenopus laevis Cytochrome P450, Family 26, Subfamily A, Polypeptide 1 (CYP26A1) interaction partners

  1. Retinoic acid is regulated by CYP26 in vertebrate lens regeneration.

  2. Results suggest that xCOUP-TF and xCyp26 are both regulated by Wnt (show WNT2 Proteins) signaling, and cooperatively function in retinoic acid (RA) signaling to affect anterior-posterior (A-P) neural patterning.

Human Cytochrome P450, Family 26, Subfamily A, Polypeptide 1 (CYP26A1) interaction partners

  1. CYP26A1 polymorphisms were associated with increased risk of malignant oral disorders in betel quid chewers.

  2. CYP26A1-mediated oncogenic characteristics may be partially responsible for the elevated expression of fascin (show FSCN1 Proteins).

  3. Molecular recognition of CYP26A1 binding pockets and structure-activity relationship studies for design of potent and selective retinoic acid metabolism blocking agents has been described.

  4. data suggested that CYP26A1 overexpression might contribute to the development and progression of cervical malignancies and squamous neoplasia of the head and neck

  5. HNF4alpha (show HNF4A Proteins) coordinates with retinoic acid receptors in a retinoic acid-dependent manner to strongly induce CYP26A1 gene expression in the liver, which may explain the high level of response to retinoic acid observed in vivo.

  6. In liver microsomes, CYP26A1 plays a role in clearing bioactive retinoids.

  7. CYP26 is able to inactivate retinoids in serum, preventing retinoic acid signaling and thus bone-marrow hematopoietic stem cell differentiation.

  8. The promoter region of CYP26A1 is significantly hypermethylated in allergic asthmatic subjects.

  9. Our observation suggests an involvement of enhanced CYP26A1 expression causing a functional vitamin A deficieny state in skin that can potentially lead to neoplastic transformation of keratinocytes in an early phase during skin carcinogenesis

  10. CYP26A1 and CYP26B1 (show CYP26B1 Proteins) are qualitatively similar retinoic acid hydroxylases with overlapping expression profiles; CYP26A1 has higher catalytic activity than CYP26B1 (show CYP26B1 Proteins).

Mouse (Murine) Cytochrome P450, Family 26, Subfamily A, Polypeptide 1 (CYP26A1) interaction partners

  1. deletion of both Cyp26a1 and Cyp26b1 in either sertoli or germ cells resulted in increased vacuolization within the seminiferous tubules, delayed spermatid release, and an increase in the number of STRA8-positive spermatogonia

  2. Analysis of retinoic-responsive genes, such as Cyp26a1 in embryos suggests that beta-carotene cleavage results in the production of retinoic acid which then can be used by the embryo during severe vitamin A deficiency.

  3. The cytochrome P450 enzyme Cyp26a1, which metabolizes all-trans-retinoic acid (RA) and thereby reduces RA levels, plays a crucial role in specifying motor neuron columnar subtypes.

  4. Liver Cyp26a1 activity is increased during pregnancy.

  5. These data demonstrate that uterine cyp26a1 activity is important for the maintenance of pregnancy, especially during the process of blastocyst implantation.

  6. Differential expression of the retinoic acid-metabolizing enzymes CYP26A1 and CYP26B1 (show CYP26B1 Proteins) during murine organogenesis.

  7. Cyp26a1(-/-) mouse fetuses have lethal morphogenetic phenotypes mimicking those generated by excess retinoic acid administration.

  8. Ablation of the gene for RARgamma (Rarg) rescues Cyp26a1-null mutant animals from caudal regression and embryonic lethality.

  9. Cyp26a1 degrades retinoic acid within the equatorial retina during later eye development.

  10. The identification of a functional retinoic acid response element located 2.0 kb upstream of the Cyp26A1 transcriptional start site is reported.

Zebrafish Cytochrome P450, Family 26, Subfamily A, Polypeptide 1 (CYP26A1) interaction partners

  1. Cyp26a1 expression can shape a retinoic acid gradient.

  2. Retinoic acid (RA)-responsive genes are differentially sensitive to alterations in the RA pathway and, in particular, cyp26a1 and raraa are under a high pressure to maintain signaling integrity.

  3. In zebrafish, two Cyp26 enzymes, Cyp26a1 and Cyp26c1, are expressed in the anterior lateral plate mesoderm (ALPM) and predominantly overlap with vascular progenitors (VPs).

  4. Zebrafish cyp26a1 promoter contains a novel retinoic acid response element that plays crucial roles in regulating its expression during early development.

  5. cyp26 has an important role in linking the Fgf, Wnt (show WNT2 Proteins) and RA signals to regulate AP patterning of the neural ectoderm in the late blastula to gastrula embryo in zebrafish

  6. The metabolites of all-trans RA produced by Cyp26D1 were the same as that produced by Cyp26A1, which are mainly 4-hydroxy-all-trans-RA and 4-oxo-all-trans-RA.

  7. Expression of Cyp26a1 is under complex feedback and feedforward control by retinoic acid and fibroblast growth factor signaling.

  8. 2.5 k fragment underlies the regulation of the zebrafish cyp26a1 gene by retinoic acid

  9. Cyp26 enzymes function in endoderm to regulate pancreatic field size

CYP26A1 Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported.

Alternative names and synonyms associated with CYP26A1

  • cytochrome P450, family 26, subfamily A, polypeptide 1 (cyp26a1)
  • cytochrome P450 26A1-like (LOC100739734)
  • cytochrome P450, family 26, subfamily A, polypeptide 1 (CYP26A1)
  • cytochrome P450, family 26, subfamily a, polypeptide 1 (Cyp26a1)
  • cytochrome P450, subfamily XXVIA, polypeptide 1 (cyp26a1)
  • retinoic acid converting enzyme (cyp26a1)
  • cb24 protein
  • CP26 protein
  • Cyp26 protein
  • CYP26A protein
  • id:ibd5061 protein
  • P450RA protein
  • P450RAI protein
  • P450RAI1 protein
  • RACE protein
  • RAH protein
  • wu:fb81e05 protein
  • xCYP26 protein
  • XCYP26A1 protein

Protein level used designations for CYP26A1

retinoic acid converting enzyme , P450, retinoic acid-inactivating, 1 , cytochrome P450 26A1 , cytochrome P450 retinoic acid-inactivating 1 , cytochrome P450, subfamily XXVIA, polypeptide 1 , cytochrome P450RAI , hP450RAI , retinoic acid 4-hydroxylase , retinoic acid-metabolizing cytochrome , cytochrome P450, 26, retinoic acid A1 , retinoic acid hydrolase , retinoic acid-degrading enzyme CYP26 , cytochrome P450 retinoic acid hydroxylase , cytochrome P450, 26, retinoic acid , retinoic acid hydroxylase , cytochrome P450 26 , etID42255.12 , gir , giraffe , RACE , retinoic acid-converting enzyme , xCYP26

496314 Xenopus laevis
548901 Xenopus (Silurana) tropicalis
100739734 Sus scrofa
1592 Homo sapiens
13082 Mus musculus
408183 Gallus gallus
486804 Canis lupus familiaris
100124374 Sus scrofa
539047 Bos taurus
154985 Rattus norvegicus
30381 Danio rerio
398094 Xenopus laevis
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