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Study shows that the PRC2 core components are enriched in retinal progenitors and downregulated in differentiated cells. Knockdown of the PRC2 core component Ezh2 leads to reduced retinal progenitor proliferation.
the activated CDK5 (show CDK5 ELISA Kits) kinase is involved in the EZH2 phosphorylation that is required for FBW7 (show FBXW7 ELISA Kits)-mediated degradation.
This perspective describes recent findings in pathogenic role of EZH2 in hematological malignancies. [review]
EZH2 expression in NSCLC and adenocarcinoma may have a role in significantly poorer survival
High EZH2 expression is associated with prostate cancer.
These evidences suggest that EZH2 and EZH1 (show EZH1 ELISA Kits) are important in the counter-balancing mechanisms controlling proliferation/resting of lymphoid cells. The disruption of the balanced EZH2/EZH1 ratio may play important roles in the pathogenesis of lymphomas
Melatonin inhibits tumorigenicity of glioblastoma stem-like cells via the AKT (show AKT1 ELISA Kits)-EZH2-STAT3 (show STAT3 ELISA Kits) signaling axis.
Data indicate that NFIB (show NFIB ELISA Kits) protein increases EZH2 protein expression downstream of BRN2 (show POU3F2 ELISA Kits) protein, which further decreases MITF (show MITF ELISA Kits) protein levels.
nuclear expression in a majority of the lymphoblasts from bone marrow clot (show TXNDC17 ELISA Kits) preparations of each of the study cases for both silent mating type information regulation 2 homolog 1 (SIRT1 (show SIRT1 ELISA Kits)), an NAD+ histone deacetylase (show HDAC1 ELISA Kits) and enhancer of Zeste homolog 2 (EZH2), a histone methyltransferase.
The results of Trans-well and cell scratch tests showed that when ANCR (show ube3a ELISA Kits) expression was decreased, the invasion and migration abilities of SW620 cells significantly declined. In conclusion, these results suggest that lncRNA-ANCR (show ube3a ELISA Kits) could influence the invasion and migration of CRC (show CALR ELISA Kits) cells by specifically binding to EZH2.
exon-skipping event in Enhancer of Zeste Homologue 2 (EZH2) along with expression changes showed significant down regulation on Day 5 and Day 9 but returned to normal level on Day 13 and Day 17.
The Ezh2 expression could be clearly seen in outer and inner hair cells, supporting cells, the stria vascularis, and spiral ganglion cells. Ezh2 continued to be expressed in the cochlear epithelium of adult mice.
Genetic inactivation of Ezh2 or Eed (show EED ELISA Kits) cooperates with NRASQ61K in leukemogenesis.
Study demonstrated that redundant EZH2 shifted mesenchymal stem cell lineage commitment to adipocyte, which contributed to the development of osteoporosis.
Data indicate increased natural killer (NK) lineage cells in Ezh2 (enhancer of zeste homolog 2)-deficient mice.
Ezh2 cooperates with let-7 microRNAs in silencing the fetal gene signature in BM HSPCs and restricts their transformation.
Conditional deletion of Ezh2 in the developing midbrain resulted in decreased neural progenitor proliferation, which is associated with derepression of cell cycle inhibitors and negative regulation of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling.
The dichotomous function of EZH2 in regulating differentiation and senescence in effector and regulatory T cells helps to explain the apparent existing contradictions in literature.
Modulation of Polycomb repressive complexes by either Ezh2 overexpression or Eed deletion enhances KRAS-driven adenomagenesis and inflammation
Study used Ezh2 conditional knockout mice to clarify the role of histone H3K27me3 modification in the retina
The presence of EZH2 is required to control progressive differentiation of milk secreting epithelium during pregnancy.
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
enhancer of zeste 2
, enhancer of zeste homolog 2 (Drosophila)
, Polycomb protein EZH2
, histone-lysine N-methyltransferase EZH2
, histone-lysine N-methyltransferase EZH2-like
, Enhancer of zeste homolog 2-A
, Polycomb protein EZH2-A
, lysine N-methyltransferase 6
, enhancer of zeste homolog 2
, eyes absent homolog 2