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Study shows that the PRC2 core components are enriched in retinal progenitors and downregulated in differentiated cells. Knockdown of the PRC2 core component Ezh2 leads to reduced retinal progenitor proliferation.
study provides evidence that epigenetic regulation of Reelin (show RELN ELISA Kits) by Ezh2 maintains appropriate Reelin (show RELN ELISA Kits) expression pattern to fulfill proper orientation of migrating neurons
Data show that basal-like subgroup was enriched for aggressive tumors and somatic mutations in trithorax-group genes and it overexpressed polycomb (show CBX2 ELISA Kits) genes EZH2 and CBX2 (show CBX2 ELISA Kits).
The miR (show MLXIP ELISA Kits)-335 expression was inversely correlated with Sox4 expression in the identical clinical specimens, but it was not related to the prognosis. Sox4/Ezh2 axis was closely associated with the prognosis in pancreatic cancer patients
EZH2 is highly expressed in pituitary adenomas, positively associated with Ki-67 (show MKI67 ELISA Kits) expression, and associated with proliferation.
A xenograft tumor model was used to confirm that EZH2 depletion inhibited HNSCC cell growth and induced tumor cell apoptosis.
Activation of EZH2 and SUZ12 (show SUZ12 ELISA Kits) Regulated by E2F1 (show E2F1 ELISA Kits) Predicts the Disease Progression and Aggressive Characteristics of Bladder Cancer
Honokiol inhibits bladder tumor growth by suppressing EZH2/miR (show MLXIP ELISA Kits)-143 axis.
Data indicate an epigenetic prognostic signature in glioblastomas based on expression of polycomb (show CBX2 ELISA Kits) repressive complex 2 (EZH2), DNA-methyltransferases DNMT1 (show DNMT1 ELISA Kits) and 3B which can be used easily in routine neuropathology practice.
High-level EZH2 and H3K27me3 were common in DLBCL independent of cell-of-origin and EZH2 mutation.
Cancer stem cell markers are variably expressed in prostate adenocarcinoma and immunohistochemical staining for ALDH1 (show ALDH1A1 ELISA Kits) and EZH2 may have a role in predicting tumour aggressiveness before treatment of prostate cancer
Data indicate increased natural killer (NK) lineage cells in Ezh2 (enhancer of zeste homolog 2)-deficient mice.
Ezh2 cooperates with let-7 microRNAs in silencing the fetal gene signature in BM HSPCs and restricts their transformation.
Conditional deletion of Ezh2 in the developing midbrain resulted in decreased neural progenitor proliferation, which is associated with derepression of cell cycle inhibitors and negative regulation of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling.
The dichotomous function of EZH2 in regulating differentiation and senescence in effector and regulatory T cells helps to explain the apparent existing contradictions in literature.
Modulation of Polycomb repressive complexes by either Ezh2 overexpression or Eed deletion enhances KRAS-driven adenomagenesis and inflammation
Study used Ezh2 conditional knockout mice to clarify the role of histone H3K27me3 modification in the retina
The presence of EZH2 is required to control progressive differentiation of milk secreting epithelium during pregnancy.
These results clearly demonstrated an essential role of Ezh1 (show EZH1 ELISA Kits) in the pathogenesis of hematopoietic malignancies induced by Ezh2 insufficiency, and highlighted the differential functions of Ezh1 (show EZH1 ELISA Kits) and Ezh2 in hematopoiesis.
Results show that EZH2 promotes mammary stem and luminal progenitor cell expansion, metastasis and inhibits ER-positive cellular differentiation.
The study characterized the binding position of Ezh2 and menin (show MEN1 ELISA Kits) at all annotated genes in embryonic stem cells and B and T lymphocytes.
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
enhancer of zeste 2
, enhancer of zeste homolog 2 (Drosophila)
, Polycomb protein EZH2
, histone-lysine N-methyltransferase EZH2
, histone-lysine N-methyltransferase EZH2-like
, Enhancer of zeste homolog 2-A
, Polycomb protein EZH2-A
, lysine N-methyltransferase 6
, enhancer of zeste homolog 2
, eyes absent homolog 2