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Study shows that the PRC2 core components are enriched in retinal progenitors and downregulated in differentiated cells. Knockdown of the PRC2 core component Ezh2 leads to reduced retinal progenitor proliferation.
Upregulated long non-coding RNA AGAP2 (show AGAP2 ELISA Kits)-AS1 (show PTGDR ELISA Kits) represses LATS2 and KLF2 (show KLF2 ELISA Kits) expression through interacting with EZH2 and LSD1 (show KDM1A ELISA Kits) in non-small-cell lung cancer cells.
These findings elucidate a mechanism by which EZH2 and BCL6 (show BCL6 ELISA Kits) cooperate to repress bivalent promoters in germinal center B cells, and provide a rationale for combined treatment with EZH2 and BCL6 (show BCL6 ELISA Kits) inhibitors in patients with DLBCL.
EZH2 has prognostic value and may play an oncogenic role in Merkel cell carcinoma.
The increased expression of p21 (show CDKN1A ELISA Kits) and p27 (show PAK2 ELISA Kits) upon MALAT1 knockdown was regulated by enhancer of zeste homolog 2 (EZH2).
Study corroborated that EZH2 mRNA expression is increased in MPNST but failed to confirm its reported pivotal role in MPNST pathogenesis as EZH2 knockdown by siRNA did not interfere with cellular proliferation and viability.
NEK2 (show NEK2 ELISA Kits) has a role in maintaining glioma stem cells in glioblastoma by stabilizing the EZH2 protein
Study suggests a mechanism for EZH2-H3K27me3 epigenetic repression of DLC1 (show DYNLL1 ELISA Kits) and multilayered regulation of DLC1 (show DYNLL1 ELISA Kits)/Rho/ROCK signaling by EZH2, and advocated the significant pro-metastatic role of EZH2 via repressing tumor and metastasis suppressors.
EZH2 overexpression in human pituitary adenomas, especially invasive adenomas, and regulates tumor invasiveness, proliferation, and angiogenesis.
miR (show MLXIP ELISA Kits)-34a expression is silenced epigenetically by EZH2 and DNA methylation (show HELLS ELISA Kits), which promotes cholangiocarcinoma cell growth through activation of the Notch (show NOTCH1 ELISA Kits) pathway.
Ezh2(Y641F) induces lymphoma and melanoma through a vast reorganization of chromatin structure
High EZH2 expression is associated with Neuroblastoma (show ARHGEF16 ELISA Kits).
Biochemical as well as functional experiments revealed that Spt6 could compete for binding of the PRC2 methyltransferase Ezh2 to Suz12 (show SUZ12 ELISA Kits) and reduce PRC2 chromatin engagement.
These findings indicate that Ezh2 targets are the major targets of the epigenetic switch in MDS (show MECOM ELISA Kits) with Ezh2 insufficiency.
Insight regarding how androgen-induced extranuclear kinase signaling and intranuclear transcription through Ezh2 modifications may influence the expression pattern of genes, ultimately affecting various downstream physiological processes.
results uncover a crucial role for EZH2 in adaptive lymphocytes to control the developmental timing of effectors of the pre-Ag receptor checkpoints
These findings identify the Ezh2-Hsp90 (show HSP90 ELISA Kits) interaction as a previously unrecognized mechanism essential for T-cell responses and an effective target for controlling graft-versus-host disease.
Eed (show EED ELISA Kits) and Ezh2 have distinct roles in urothelial differentiation
Findings uncover an Ezh2-dependent mechanism to restrict the smooth muscle gene expression program in the developing mesothelium and allow appropriate cell fate decisions to occur in this multipotent mesoderm lineage.
The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 (show E2F1 ELISA Kits) to recruit EZH2 to diverse repeat sequences.
This study identified Ezh2 as enriched in melanoma cancer stem cells (MCS (show SMCP ELISA Kits) cells) and showed that Ezh2 knockdown or treatment with small molecule Ezh2 inhibitors reduces MCS (show SMCP ELISA Kits) cell spheroid formation, survival, invasion and migration.
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
enhancer of zeste 2
, enhancer of zeste homolog 2 (Drosophila)
, Polycomb protein EZH2
, histone-lysine N-methyltransferase EZH2
, histone-lysine N-methyltransferase EZH2-like
, Enhancer of zeste homolog 2-A
, Polycomb protein EZH2-A
, lysine N-methyltransferase 6
, enhancer of zeste homolog 2
, eyes absent homolog 2