Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species
Study shows that the PRC2 core components are enriched in retinal progenitors and downregulated in differentiated cells. Knockdown of the PRC2 core component Ezh2 leads to reduced retinal progenitor proliferation.
demonstrated that EZH2 plays a crucial role in tumor growth and distant metastasis in osteosarcoma; its oncogenic role is related to its regulation of the expression of TSSC3 (show PHLDA2 ELISA Kits)
EZH2 has a critical role in the proliferation and viability of melanoma
DKK1 (show DKK1 ELISA Kits) is found to be regulated by NBAT1 in a PRC2 dependent manner, and is responsible for NBAT1's effects in inhibiting migration and invasion of breast cancer cells.
Studies indicate that polycomb (show CBX2 ELISA Kits) repressive complex 2 (EZH2) is overexpressed in multiple tumor types and is often an independent prognostic indicator.
Suggest that acquired-resistance to EZH2i may arise in WT and mutant EZH2 patients through a single mutation that remains targetable by second generation EZH2 inhibitors.
miR (show MLXIP ELISA Kits)-506-EZH2 axis inhibits colon tumor cell proliferation and metastasis by activating/suppressing specific downstream tumor-associated genes and the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling pathway.
our study suggests a possible epigenetic mechanism of p16 loss in CDKN2A non-deleted high grade gliomas mediated by strong EZH2 expression
Data suggest that, during neurogenesis, Mediator complex cyclin (show PCNA ELISA Kits)-dependent kinases (CDK8 (show CDK8 ELISA Kits), CDK19 (show CDK19 ELISA Kits)) interact directly with PRC2 (polycomb (show CBX2 ELISA Kits) repressive complex 2) subunit EZH2 (enhancer of zeste homolog 2), as well as SUZ12 (suppressor of zeste 12 homolog (show SUZ12 ELISA Kits)).
EZH2 protein expression was associated with a tumor suppressor gene methylator phenotype. DNMT1 (show DNMT1 ELISA Kits), DNMT3B (show DNMT3B ELISA Kits), and EZH2 were expressed at significantly higher levels in tumor vs. normal tissues.
Uropathogen-induced paracrine factors act epigenetically by altering expression of EZH2, which plays a key role in early host cell proliferative responses to infection.
Data indicate increased natural killer (NK) lineage cells in Ezh2 (enhancer of zeste homolog 2)-deficient mice.
Ezh2 cooperates with let-7 microRNAs in silencing the fetal gene signature in BM HSPCs and restricts their transformation.
Conditional deletion of Ezh2 in the developing midbrain resulted in decreased neural progenitor proliferation, which is associated with derepression of cell cycle inhibitors and negative regulation of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling.
The dichotomous function of EZH2 in regulating differentiation and senescence in effector and regulatory T cells helps to explain the apparent existing contradictions in literature.
Modulation of Polycomb repressive complexes by either Ezh2 overexpression or Eed deletion enhances KRAS-driven adenomagenesis and inflammation
Study used Ezh2 conditional knockout mice to clarify the role of histone H3K27me3 modification in the retina
The presence of EZH2 is required to control progressive differentiation of milk secreting epithelium during pregnancy.
These results clearly demonstrated an essential role of Ezh1 (show EZH1 ELISA Kits) in the pathogenesis of hematopoietic malignancies induced by Ezh2 insufficiency, and highlighted the differential functions of Ezh1 (show EZH1 ELISA Kits) and Ezh2 in hematopoiesis.
Results show that EZH2 promotes mammary stem and luminal progenitor cell expansion, metastasis and inhibits ER-positive cellular differentiation.
The study characterized the binding position of Ezh2 and menin (show MEN1 ELISA Kits) at all annotated genes in embryonic stem cells and B and T lymphocytes.
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
enhancer of zeste 2
, enhancer of zeste homolog 2 (Drosophila)
, Polycomb protein EZH2
, histone-lysine N-methyltransferase EZH2
, histone-lysine N-methyltransferase EZH2-like
, Enhancer of zeste homolog 2-A
, Polycomb protein EZH2-A
, lysine N-methyltransferase 6
, enhancer of zeste homolog 2
, eyes absent homolog 2