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three dimensional structure of MLL5 SET domain unveils the structural basis for its lack of methyltransferase activity
MLL5 preserves spindle bipolarity through maintaining cytosolic PLK1 (show PLK1 ELISA Kits) in a nonaggregated form.
MLL5 interacts with OGT (show OGT ELISA Kits) and USP7 (show USP7 ELISA Kits) to form a stable ternary complex. Upregulation of MLL5 expression was correlated with increased expression of OGT (show OGT ELISA Kits) and USP7 (show USP7 ELISA Kits) in human primary cervical adenocarcinomas.
Suggest a role for MLL5 and H3.3 in maintaining self-renewal hierarchies in adult glioblastomas.
O-GlcNAcylation of MLL5beta at T440 residue is critical for MLL5 recruitment to the HPV16/18-long control region through its interaction with AP-1 (show FOSB ELISA Kits).
Improved outcome is observed in decitabine-treated patients who express MLL5 at high levels.
KMT2E expression retained association with poor acute promyelocytic leukaemia remission rate and shorter survival while the association with disease-free survival was of marginal significance.
NMR solution structure of the MLL5 PHD (show PDC ELISA Kits) domain
these results indicate that the suppression of MLL (show MLL ELISA Kits) genes, especially MLL2 (show MLL2 ELISA Kits) and MLL5, take part in modulating breast carcinogenesis.
MLL5 is a cellular ligand for the natural cytotoxicity receptor NKp44 (show NCR2 ELISA Kits).
inactivation of the Mll5 gene in mice results in a 30% reduction in the average representation of hematopoietic stem cells and in functional impairment of long-term hematopoietic repopulation potential under competitive conditions
MLL5 is a key regulator of normal hematopoiesis
findings establish several nonredundant functions for Mll5, including an essential role in regulating proliferation and functional integrity of hematopoietic stem/progenitor cells
MLL5 plays an integral role in novel chromatin regulatory mechanisms that suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells.
This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized.
histone-lysine N-methyltransferase 2E
, histone-lysine N-methyltransferase MLL5
, lysine N-methyltransferase 2E
, myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
, myeloid/lymphoid or mixed-lineage leukemia protein 5
, myeloid/lymphoid or mixed-lineage leukemia 5
, myeloid/lymphoid or mixed-lineage leukemia protein 5 homolog