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the S. pombe ICln protein is required for optimal production of the spliceosomal snRNPs and for efficient splicing in vivo
functional interaction between ICln and HSPC038
RioK1 (show RIOK1 Proteins), a new interactor of protein arginine methyltransferase 5 (PRMT5 (show PRMT5 Proteins)), competes with pICln for binding and modulates PRMT5 (show PRMT5 Proteins) complex composition and substrate specificity.
revealed an increase of ICln in the mesothelioma cell membrane under hypotonic conditions, an event possibly related to the activation of Cl(-) channels
ICln interacts with integrin alphaIIbbeta3 and regulates platelet activation.
Data show that ICln159, a truncated ICln mutant, belongs to the pleckstrin (show PLEK Proteins) homology (PH) domain family of proteins and interacts with LSm4 (show LSM4 Proteins), a protein involved in splicing and mRNA degradation.
Lsm10 (show LSM10 Proteins) and Lsm11 (show LSM11 Proteins), which replace the Sm proteins D1 and D2 in the histone RNA processing U7 snRNPs, associate with pICln in vitro and in vivo without receiving sDMA modifications and with PRMT5 (show PRMT5 Proteins) and SMN (show STMN1 Proteins) complexes
ICln associates with the cell membrane after cell swelling
This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6.
methylosome subunit pICln
, chloride channel, nucleotide-sensitive, 1A
, chloride channel regulatory protein
, chloride channel, nucleotide sensitive 1A
, chloride conductance regulatory protein ICln
, chloride ion current inducer protein
, reticulocyte pICln
, reticulocyte protein ICln
, chloride channel current inducer
, chloride channel regulator
, Clns 1a
, swelling-induced chloride conductance regulatory protein