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These data suggest a role for Drosophila Ddx1 in stress-induced regulation of splicing.
DEAD-box protein (show INTS6 ELISA Kits) Bel (show LHX2 ELISA Kits) has evolutionarily conserved roles in fertility and development.
Data provide evidence for a role for DDX1 in resolving RNA-DNA structures that accumulate at DNA double-strand breaks located at sites of active transcription thereby facilitating repair by homologous recombination.
crystal structure of the SPRY domain of human DDX1 (hDSPRY) is reported at 2.0 A resolution
HIV-1 wild type Tat (show TAT ELISA Kits) co-immunoprecipitated with DDX1.
Data indicate a tight binding of DEAD-box protein DDX1 to adenosine diphosphate (ADP), one of the strongest affinities observed for DEAD-box helicases.
hCLE/C14orf166 associates with DDX1, HSPC117, and FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.
archease (also called ZBTB8OS), a protein of unknown function, is required for full activity of the human tRNA ligase complex and, in cooperation with DDX1, facilitates the formation of an RTCB-guanylate intermediate central to mammalian RNA ligation
subcellular localization of KSRP (show KHSRP ELISA Kits) is regulated by competing interactions with DDX1 or 14-3-3 (show YWHAQ ELISA Kits)
DDX1 depletion causes accumulation of DNA damage in response to cisplatin and defects in DNA repair of double-stranded breaks.
DDX1 was shown to be an RNA-activated ATPase (show DNAH8 ELISA Kits), wherein Rev-bound RNA was equally effective at stimulating ATPase (show DNAH8 ELISA Kits) activity as protein-free RNA.
DDX1 acts as a cellular cofactor by promoting oligomerization of Rev on the Rev response element.
we show that the transcript levels of an RNA helicase, Ddx1, regulates strain differences in the amount of nitric oxide produced by macrophage after stimulation with interferon gamma (show IFNG ELISA Kits) and tumor necrosis factor (show TNF ELISA Kits).
Coronavirus N phosphorylation by GSK-3 (show GSK3b ELISA Kits) allows recruitment of the RNA helicase DDX1, which facilitates template readthrough and enables longer viral positive-sense single-stranded genomic RNA synthesis.
DDX1 promotes the expression of a subset of microRNAs. Knockdown of DDX1 promotes ovarian tumor invasion and metastasis.
DDX1-DDX21 (show DDX21 ELISA Kits)-DHX36 (show DHX36 ELISA Kits) complex represents a dsRNA sensor that uses the TRIF (show RNF138 ELISA Kits) pathway to activate type I IFN responses in the cytosol of myeloid dendritic cells
DDX1 mRNA was produced in both seminoma and nonseminoma types of human testicular germ cell tumor samples
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin.
, DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
, ATP-dependent RNA helicase DDX1
, DEAD box polypeptide 1
, DEAD box protein 1
, DEAD box protein retinoblastoma
, DEAD box-1
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1
, DEAD box protein DDX1