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Specific mutations in the yeast Sm protein ring expose a requirement for assembly factor Brr1, a homolog of human Gemin2.
The authors propose that Gemin2 is a versatile hub for ribonucleoprotein (show RBP31 ELISA Kits) exchange that functions broadly in RNA metabolism.
Two monoclonal antibodies against SMN (show STMN1 ELISA Kits) (survival-of-motor-neurons) protein bind to its site of interaction with gemin2.
several conserved SMN (show STMN1 ELISA Kits) residues, including the sites of two SMA (show SMN1 ELISA Kits) patient mutations, are not required for binding to Gemin2. Instead, they form a conserved SMN (show STMN1 ELISA Kits)/Gemin2 surface that may be functionally important for snRNP (show LSM2 ELISA Kits) assembly.
Overexpression of SIP1 and downregulation of E-cadherin (show CDH1 ELISA Kits) is associated with delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma after partial glossectomy
purified SMN (show STMN1 ELISA Kits)-GEMIN2 fusion protein enhanced the RAD51 (show RAD51 ELISA Kits)-mediated homologous pairing much more efficiently than GEMIN2 alone
Study identified Gemin2 as the protein that binds a pentamer of Sm proteins comprised of SmD1 (show SNRPD1 ELISA Kits)/D2 and SmF (show SNRPF ELISA Kits)/E/G; the crystal structure of this complex bound to SMN's Gemin2 binding domain to 2.5 A was determined.
Novel monoclonal antibodies detect SIP1 in the cytoplasm of human cells from multiple tumor tissue arrays.
This study demonstrated that miR (show MLXIP ELISA Kits)-141 levels correlate inversely with SIP1 protein levels as well as cell migration and invasion of CRC (show CALR ELISA Kits) cells; SIP1 was identified as a functional target of miR (show MLXIP ELISA Kits)-141.
This study supports the rationale for developing SIP1 as a potential therapeutic and diagnostic target for gliomas
utilised a targeted screen to identify mRNA associated with SMN (show STMN1 ELISA Kits), Gemin2 and Gemin3 (show DDX20 ELISA Kits) in the cytoplasm of a human neuroblastoma (show ARHGEF16 ELISA Kits) cell line, SHSY5Y
Gene targeting in mice reveals a correlation between defects in the biogenesis of U snRNPs and motoneuron cell death (gemin2; SMN interacting protein 1)
Reduction of Gemin2, unlike reduction of SMN (show SNRPN ELISA Kits), in zebrafish embryos does not directly cause motor axon outgrowth defects.
This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
SMN interacting protein 1-delta
, component of gems 2
, gem-associated protein 2
, survival of motor neuron protein interacting protein 1
, SMN-interacting protein 1
, survival of motor neuron protein-interacting protein 1
, survivor of motor neuron protein interacting protein 1
, SMN interacting protein-1
, Survival of motor neuron protein-interacting protein 1