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Human GEMIN6 Protein expressed in Escherichia coli (E. coli) - ABIN1098564
Carissimi, Saieva, Gabanella, Pellizzoni: Gemin8 is required for the architecture and function of the survival motor neuron complex. in The Journal of biological chemistry 2006
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Gemin6 is a component of the SMN (show STMN1 Proteins) complex that localizes to gems and interacts with several Sm proteins of the spliceosomal snRNPs.
Gemin8 (show GEMIN8 Proteins) has an essential role in the proper structural organization of the SMN (show STMN1 Proteins) complex and the involvement of the heteromeric subunit containing Gemin6, Gemin7 (show GEMIN7 Proteins), Gemin8 (show GEMIN8 Proteins), and Unrip (show STRAP Proteins) in the recruitment of Sm proteins to the snRNP (show LSM2 Proteins) assembly pathway
GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1\; MIM 602595), GEMIN3 (DDX20\; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).
, gem-associated protein 6
, gemin 6